Abstract
At The Cleveland Clinic we began to use Tisseel in 1986. Since 1987 we have used the drug in 340–450 cases per year, or 11%–15% of all cardiac operations annually. In 1991 Tisseel was used in 41% of cardiac reoperations, and cardiac reoperations comprised 86% of the indications for Tisseel use (diffuse low pressure bleeding). With a total experience of 2129 applications, we have found this to be an effective hemostatic agent and no drug related complications have been identified.
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McCarthy, P.M., Borsh, J., Cosgrove, D.M. (1995). Fibrin Sealant: The Cleveland Clinic Experience. In: Schlag, G., Wolner, E., Eckersberger, F. (eds) Fibrin Sealing in Surgical and Nonsurgical Fields. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79227-4_4
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DOI: https://doi.org/10.1007/978-3-642-79227-4_4
Publisher Name: Springer, Berlin, Heidelberg
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