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Whole Body and Organ Measures of O2 Availability

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Clinical Trials for the Treatment of Sepsis

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 19))

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Abstract

It is generally accepted that maintaining an “adequate” (or “optimal”) level of oxygen delivery is an important therapeutic goal in the management of patients with sepsis or septic shock. There is much controversy, however, about the proper way to define and monitor the adequacy of oxygen delivery (DO2) in sepsis. This controversy reflects our poor understanding — despite more that thirty years of intensive research — of the effects of sepsis on cellular oxygen utilization (VO2) and energy metabolism. Indeed, the very notion that organ dysfunction in sepsis occurs as a result of cellular energy starvation remains an attractive, but poorly substantiated, hypothesis.

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  1. M. P. Fink
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  1. Department of Critical Care, Victoria Hospital, 375 South Street, N6A 4G5, London, Ontario, Canada

    W. J. Sibbald

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Fink, M.P. (1995). Whole Body and Organ Measures of O2 Availability. In: Vincent, JL., Sibbald, W.J. (eds) Clinical Trials for the Treatment of Sepsis. Update in Intensive Care and Emergency Medicine, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79224-3_7

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  • DOI: https://doi.org/10.1007/978-3-642-79224-3_7

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