Evaluation of the Adequacy of Source Control

  • J. C. Marshall
  • S. F. Lowry
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 19)


Multiple Organ Dysfunction Syndrome Source Control Infectious Challenge Chronic Ambulatory Peritoneal Dialysis Septic Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Lowry SF, VanZee KJ, Moldawer LL (1992) Strategies for modulation of systemic and tissue cytokine responses to sepsis. In: Lamy M, Thijs LG (eds) Update in Intensive Care and Emergency Medicine. Volume 16: Mediators of Sepsis. Springer-Verlag, Berlin, pp 345–361Google Scholar
  2. 2.
    Giroir BP (1993) Mediators of septic shock: New approaches for interrupting the endogenous inflammatory cascade. Crit Care Med 21: 780–789PubMedCrossRefGoogle Scholar
  3. 3.
    Natanson C, Hoffman WD, Suffredini AF, Eichaker PQ, Danner RL (1994) Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Ann Intern Med 120: 771–783PubMedGoogle Scholar
  4. 4.
    Marshall JC (1994) Infection and the host septic response contribute independently to adverse outcome in critical illness: Implications for clinical trials of mediator antagonism. In: Vincent JL (ed) Yearbook of Intensive Care and Emergency Medicine 1994. Springer-Verlag, Berlin, pp 1–13Google Scholar
  5. 5.
    Meakins JL, Wicklund B, Forse RA, McLean APH (1980) The surgical intensive care unit: Current concepts in infection. Surg Clin N Am 60: 117–132PubMedGoogle Scholar
  6. 6.
    Miles AA, Miles EM, Burke J (1957) The value and duration of defence reactions of the skin to the primary lodgement of bacteria. Br J Exp Pathol 38: 79–96PubMedGoogle Scholar
  7. 7.
    Pennington JE (1979) Lipopolysaccharide Pseudomonas vaccine: Efficacy against pulmonary infection with Pseudomonas aeruginosa. J Infect Dis 140: 73–80PubMedCrossRefGoogle Scholar
  8. 8.
    Dunn DL, Nelson RD, Condie RM, Simmons RL (1993) Mechanisms of the adjuvant effect of hemoglobin in experimental peritonitis. VI. Effects of stroma-free hemoglobin and red blood cell stroma on mortality and neutrophil function. Surgery 93: 653–659Google Scholar
  9. 9.
    Cruse PJ, Foord R (1973) A five-year prospective study of 23649 surgical wounds. Arch Surg 107: 206–210PubMedGoogle Scholar
  10. 10.
    Cenci E, Romani L, Vecchiarelli A, Pucchetti P, Bistoni F (1989) Role of L3T4+ lym-phocytes in protective immunity to systemic Candida albicans infection in mice. Infect Immun 57: 3581–3587PubMedGoogle Scholar
  11. 11.
    Collins HH, Cross AS, Dobek A, Opal SM, McClain JB, Sadoff JC (1989) Oral cipro-floxacin and a monoclonal antibody to lipopolysaccharide protect leukopenic rats from lethal infection with Pseudomonas aeruginosa. J Infect Dis 159: 1073–1082PubMedCrossRefGoogle Scholar
  12. 12.
    James RC, McLeod CJ (1961) Induction of staphylococcal infection in mice with small inocula introduced on sutures. Br J Exp Pathol 42: 266–277PubMedGoogle Scholar
  13. 13.
    Howe CW, Marston AT (1962) A study on sources of postoperative staphylococcal infection. Surg Gynecol Obstet 115: 266–275PubMedGoogle Scholar
  14. 14.
    Bohnen JMA, Christou NV, Meakins JL (1987) Suppression of delayed cutaneous hypersensitivity and inflammatory cell delivery by sterile barium peritonitis. J Surg Res 43: 430–435PubMedCrossRefGoogle Scholar
  15. 15.
    Rotstein OD, Pruett TL, Simmons RL (1986) Fibrin in peritonitis. V. Fibrin inhibits phagocytic killing of Escherichia coli by human polymorphonuclear leukocytes. Ann Surg 203: 413–419PubMedCrossRefGoogle Scholar
  16. 16.
    Dunn DL, Barke RA, Ahrenholz DH, Humphrey EW, Simmons RL (1984) The adjuvant effect of peritoneal fluid in experimental peritonitis. Ann Surg 199: 37–43PubMedCrossRefGoogle Scholar
  17. 17.
    Meakins JL (1991) Surgeons, surgery, and immunomodulation. Arch Surg 126: 494–498PubMedGoogle Scholar
  18. 18.
    Bohnen JMA, Boulanger M, Meakins JL, McLean APH (1993) Prognosis in generalized peritonitis. Relation to cause and risk factors. Arch Surg 118: 285–290Google Scholar
  19. 19.
    Svanes C, Salveson H, Espehaug B (1989) A multifactorial analysis of factors related to lethality after treatment of perforated gastroduodenal ulcer 1935-1985. Ann Surg 209: 418–423PubMedCrossRefGoogle Scholar
  20. 20.
    Stamenkovic I, Lew PD (1984) Early recognition of potentially fatal necrotizing fasciitis. N Engl J Med 310: 1689–1693PubMedCrossRefGoogle Scholar
  21. 21.
    Fink MP, Heard SO (1990) Laboratory models of sepsis and septic shock. J Surg Res 49: 186–196PubMedCrossRefGoogle Scholar
  22. 22.
    Michalek SM, Moore RN, McGhee JR, Rosenstreich DL, Mergenhagen SE (1980) The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxin. J Infect Dis 141: 55–63PubMedCrossRefGoogle Scholar
  23. 23.
    Marshall JC, Sweeney D (1990) Microbial infection and the septic response in critical surgical illness. Sepsis, not infection, determines outcome. Arch Surg 125: 17–25PubMedGoogle Scholar
  24. 24.
    Tracey KJ, Beutler JB, Lowry SF, et al (1986) Shock and tissue injury induced by re-combinant human cachectin. Science 234: 470–474PubMedCrossRefGoogle Scholar
  25. 25.
    Beutler B, Milsark IW, Cerami AC (1985) Passive immunization against cachectin/ tumor necrosis factor protects mice from lethal effect of endotoxin. Science 228: 869–871CrossRefGoogle Scholar
  26. 26.
    Tracey KJ, Fong Y, Hesse DG, et al (1987) Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteremia. Nature 330: 662–664PubMedCrossRefGoogle Scholar
  27. 27.
    Alexander HR, Sheppard BC, Jensen JC, et al (1991) Treatment with recombinant human tumor necrosis factor-alpha protects rats against the lethality, hypotension and hypothermia of gram-negative sepsis. J Clin Invest 88: 34–39PubMedCrossRefGoogle Scholar
  28. 28.
    Nakane A, Minagawa T, Kato K (1988) Endogenous tumor necrosis factor (cachectin) is essential to host resistance against Listeria monocytogenes infection. Infect Immun 56: 2563–2569PubMedGoogle Scholar
  29. 29.
    Pfeffer K, Matsuyama T, Kundig TM, et al (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73: 457–467PubMedCrossRefGoogle Scholar
  30. 30.
    Ohlsson K, Bjork P, Bergenfeldt M, Hageman R, Thompson RC (1990) Interleukin-1 receptor antagonist reduces mortality from endotoxin shock. Nature 348: 550–552PubMedCrossRefGoogle Scholar
  31. 31.
    Wakabayashi G, Gelfand JA, Burke JF, Thompson RC, Dinarello CA (1991) A specific receptor antagonist for IL-1 prevents E. coli-induced shock in rabbits. FASEB J 5: 338–343PubMedGoogle Scholar
  32. 32.
    Lange JR, Alexander HR, Merino MJ, Doherty GM, Norton JA (1992) Interleukin-1 a prevention of the lethality of Escherichia coli peritonitis. J Surg Res 52: 555–559PubMedCrossRefGoogle Scholar
  33. 33.
    Mancilla J, Garcia P, Dinarello CA (1993) IL-1 receptor antagonist can either protect or enhance the lethality of Klebsiella pneumoniae sepsis in newborn rats. Infect Immun 61: 926–932PubMedGoogle Scholar
  34. 34.
    Gerard C, Bruyns C, Marchant A, et al (1993) Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 177: 547–550PubMedCrossRefGoogle Scholar
  35. 35.
    Romani L, Puccetti P, Mencacci A, et al (1994) Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans. J Immunol 152: 3514–3521PubMedGoogle Scholar
  36. 36.
    Marshall JC, Shields J (1994) Infection, host response, and organ dysfunction contribute independently to outcome in sepsis syndrome: Towards a staging system for clinical sepsis. Presented at the 14th annual meeting of the Surgical Infection Society, Toronto, OntarioGoogle Scholar
  37. 37.
    Olak J, Christou NV, Stein LA, Meakins JL (1986) Operative vs percutaneous drainage of intraabdominal abscesses: Comparison of morbidity and mortality. Arch Surg 121: 141–146PubMedGoogle Scholar
  38. 38.
    Christou NV, Barie PS, Dellinger EP, Waymack JP, Stone HH (1993) Surgical Infection Society intra-abdominal infection study. Prospective evaluation of management techniques and outcome. Arch Surg 128: 193–199PubMedGoogle Scholar
  39. 39.
    Bandyk DF, Esses GE (1994) Prosthetic graft infection. Surg Clin N Am 74: 571–590PubMedGoogle Scholar
  40. 40.
    Corder AP, Williams JD (1990) Optimal operative treatment in acute septic complications of diverticular disease. Ann Royal Coll Surg Engl 72: 82–86Google Scholar
  41. 41.
    Fry DE, Pearlstein L, Fulton RL, Polk HC (1980) Multiple system organ failure. The role of uncontrolled infection. Arch Surg 115: 136–140PubMedGoogle Scholar
  42. 42.
    Henao FJ, Daes JE, Dennis RJ (1991) Risk factors for multiorgan failure: A case-control study. J Trauma 31: 74–80PubMedCrossRefGoogle Scholar
  43. 43.
    Amoury RA (1988) Infections of the Heart. In: Howard RJ, Simmons RL (eds) Surgical Infectious Diseases. 2nd Ed. Appleton (amp;) Lange, Norwalk CT USA, Chapter 27Google Scholar
  44. 44.
    Hauser CJ, Bosco P, Davenport M (1989) Surgical management of fungal peripheral thrombophlebitis. Surgery 105: 510–514PubMedGoogle Scholar
  45. 45.
    Spence PA, Mathews RE, Khanna R (1985) Indications for operation where peritonitis occurs in patients on chronic ambulatory peritoneal dialysis. Surg Gynecol Obstet 161: 450–452PubMedGoogle Scholar
  46. 46.
    Le Gall JR, Fagniez PL, Meakins J, Brun-Buisson C, Trunet P, Carlet J (1982) Diagnostic features of early high post-laparotomy fever: A prospective study of 100 patients. Br J Surg 69: 452–455PubMedCrossRefGoogle Scholar
  47. 47.
    Stone HH, Bourneuf AA, Stinson LD (1985) Reliability of criteria for predicting persistent or recurrent sepsis. Arch Surg 120: 17–20PubMedGoogle Scholar
  48. 48.
    Polk HC, Shields CL (1977) Remote organ failure: A valid sign of occult intra-abdominal infection. Surgery 81: 310–313PubMedGoogle Scholar
  49. 49.
    Bell RC, Coalson JJ, Smith JD, Johanson WG (1983) Multiple organ system failure and infection in adult respiratory distress syndrome. Ann Intern Med 99: 293–298PubMedGoogle Scholar
  50. 50.
    Hinsdale JG, Jaffe BM (1984) Re-operation for intra-abdominal sepsis: Indications and results in a modern critical care setting. Ann Surg 199: 31–36PubMedCrossRefGoogle Scholar
  51. 51.
    Norton LW (1985) Does drainage of intra-abdominal pus reverse multiple organ failure? Am J Surg 149: 347–350PubMedCrossRefGoogle Scholar
  52. 52.
    Ziegler EJ, Fisher CJ, Sprung CL, et al (1991) Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. N Engl J Med 324: 429–436PubMedCrossRefGoogle Scholar
  53. 53.
    Siegel JP (1994) Clinical development of biological response modifiers. Can J Infect Dis 5 (Suppl A): S5A–S8AGoogle Scholar
  54. 54.
    Fisher CJ, Dhainaut J-F, Opal S, et al for the Phase III rhlL-lra Sepsis Syndrome Study Group (1994) Recombinant human interleukin-1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. JAMA 271: 1836–1843PubMedCrossRefGoogle Scholar
  55. 55.
    Knaus WA, Harrell FE, Fisher CJ, et al (1993) The clinical evaluation of new drugs for sepsis. A prospective study design based on survival analysis. JAMA 270: 1233–1241PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • J. C. Marshall
  • S. F. Lowry

There are no affiliations available

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