Zusammenfassung
Bei Vorgabe dieses Titels durch den Herausgeber ist man geneigt, z.Z. noch utopische Erwartungen zu formulieren. Wünschenswert wäre, mit Rezeptor-SPECT eine ubiquitär verfügbare, einfach einzusetzende und quantifizierbare Messung verschiedener Rezeptorsysteme des Gehirns zu ermöglichen. Dabei sollte die Untersuchung gerade für psychiatrische Patienten mit möglichst kurzer Untersuchungszeit und ohne invasive Methoden (z.B. arterielle Blutabnahmen) einhergehen.
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Literatur
Dewey SL, Smith GS, Alexoff D et al. (1994) Studies of the interactions of dopamine with other neurotransmitters: PET and in vivo microdialysis experiments. Neuropsychopharmacol 10:81S
Kung H, Pan S, Kung MP et al. (1989) In vitro and in vivo evaluation of [123I]IBZM: a potential CNS D2-dopamine receptor imaging agent. J Nucl Med 30:88–92
Kung HF, Alavi A, Chang W, Kung MP et al. (1990) In vivo SPECT imaging of CNS D2 dopamine receptors: Initial studies with iodine-123-IBZM in humans. J Nucl Med 31:573–579
Brücke T, Podreka I, Angelberger P et al. (1991) Dopamin D2 receptor imaging with SPECT: Studies in different neuropsychiatric disorders. J Cereb Blood Flow Metab 11:220–228
Wong DF, Wagner HN, Tune LE, Dannais RF, Pearlson GD et al. (1986) Positron Emission Tomography reveals elevated D2 dopamine receptors in drug-naive schizophrenics. Science 234:1558–1563
Farde L, Wiesel FA, Stone-Elander S, Halldin C, Nordström AL, Hall H, Sedvall G (1990) D2 dopamine receptors in neuroleptic-naive schizophrenic patients. Arch Gen Psychiatry 47:213–218
Seeman P, Hong-Chang G, Van Tol HHM (1993) Dopamine D4 receptors elevated in schizophrenia. Nature 365:441–445
Schlößer R, Schlegel S (to be published) D2-Receptor imaging with 123I-IBZM and single photon emission tomography in psychiatry: a survey of current status. J Neurol Transm
Pilowsky LS, Costa DC, Ell PJ, Murray RM, Verhoeff NPLG, Kerwin RW (1992) Clozapine, single photon emission tomography and the D2 dopamine receptor blockade hypothesis of schizophrenia. Lancet 340:199–202
Pilowsky LS; Costa DC, Ell PJ, Murray RM, Verhoeff NPLG, Kerwin RW (1993) Antipsychotic medication, D2 dopamine receptor blockade and clinical response: a 1231 IBZM SPET (single photon emission tomography) study. Psychological Medicine 23:791–797
Tatsch K, Schwarz J, Kerner M, Oertel WH, Kirsch CM (1993) Idiopathisches Parkinson Syndrom: 123-J-IBZM SPECT vor und unter Therapie. Nucl Med 32:A13
Klemm E, Kasper S, Broich K, Danos P, Grünwald F, Menzel C, Hotze AL, Krappel C, Möller HJ, Biersack HJ (1993) 123I-IBZM-SPECT for imaging of striatal D2-dopamine receptors and clinical variables in psychiatric patients with different diagnosis. Pharmacopsychiatry 26:168
Grünwald F, Danos P, Kasper S, Briele B, Klemm E, Möller HJ, Biersack HJ (1992) IBZM-SPECT bei psychiatrischen Erkrankungen. Nucl Med 31:A82
Schlegel S, Steinert H, Nickel O, Schlößer R, Hiemke Ch, Wetzel H, Fischer S, Hahn K (1993) IBZM- SPECT bei Neuroleptikatherapie. In: Baumann P (Hrsg) Biologische Psychiatrie der Gegenwart. Springer, Wien, New York, S520–522
D’Haenen H, Bossuyt A (1994) Dopamine D2 receptors in depression measured with single photon emission computed tomography. Biol Psychiatry 35:128–132
Geaney DP, Ellis PM, Soper N, Shepstone BJ, Cowen P (1992) Single Photon Emission Tomography assessment of cerebral dopamine D2 receptor blockade in schizophrenia. Biol Psychiatry 32:293–295
Farde L, Wiesel FA, Halldin C, Sedvall G (1988) Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs. Arch Gen Psychiatry 45:171–76
Laruelle M, van Dyck C, Abi-Dargham A, Zea-Ponce Y, Zoghbi SS, Charney DS, Baldwin RM, Hoffer PB, Kung HF, Innis RB (1994) Compartmental modeling of iodine- 123-iodobenzofuran binding to dopamine D2 receptors in healthy subjects. J Nucl Med 35:743–754
Kung HF (1993) SPECT and PET ligands for CNS imaging. Neurotransmissions IX:l-8
Brücke T, Kornhuber J, Angelberger P, Asenbaum S, Frassine H, Podreka I (1993) SPECT imaging of dopamine and serotonin transporters with [123]beta-CIT. Binding kinetics in the human brain. J Neural Transm Gen Sect 94:137–146
Laruelle M, Baldwin RM, Malison RT, Zea-Ponce Y, Zoghbi SS, AI-Trikriti MS, Sybirska EH, Zimmermann RC, Wisniewski G, Neumeyer JL et al. (1993) SPECT imaging of dopamine and serotonin transporters with [123]beta-CIT: pharmacological characterization of brain uptake in nonhuman primates. Synapse 13:295–309
Madras BK (1994) Novel probes for imaging the dopamine transporter. Neuropsychophar- macology 10:80S
Davis KI, Kahn RS, Ko G, Davidson M (1991) Dopamine in schizophrenia: A review and reconceptualisation. Am J Psychiatry 148:1474–1486
Farde Li Suhara T, Halldin C et al. (1994) PET-study of extrastriatal dopamine receptors in the human brain. Neuropsychopharmacol 10:78S
Beer HF, Blaeuenstein PA, Hasler PH et al. (1990) In vitro and in vivo evaluation of iodine-123-RO 16–0154: a new imaging agent for SPECT investigations of benzodiazepine receptors. J Nucl Med 31:1007–1014
Innis RB, AI-Tikriti MS, Zoghbi SS et al. (1991) SPECT imgaging of the benzodiazepine receptor: Feasibility of in vivo potency measurements from stepwise displacement curves. J Nucl Med 32:1754–1761
Mueller WE (1987) The benzodiazepine receptor. Cambridge University Press. New York
Persson A, Pauli S, Halldin C, Stone-Elander S, Farde L, Sjögren I, Sedvall G (1989) Saturation analysis of specific nC Ro 15–1788 binding to the human cortex using positron emission tomography. Hum Psychopharmacol 4:21–31
Schlegel S, Steinert H, Bockisch A, Hahn K, Schlößer R, Benkert O (1994) Decreased benzodiazepine receptor binding in panic disorder measured by IOMAZENIL-SPECT: A preliminary report. Eur Arch Psychiatry Clin Neurosci 244:49–51
Schlegel S, Steinert H, Nickel O, Bockisch A, Schlößer R, Hahn K (1993) Benzodia- zepinrezeptordichte bei Depression im lomazenil-SPECT. Nucl Med 32:16
Cheetham SC, Crompton MR, Katona CLE, Parker SJ, Horton RW (1988) Brain GABA a / benzodiazepine binding sites and glutamatic acid decarboxylase activity in depressed suicide victims. Brain Res 460:114–123
Laruelle M, Abi-Dargham A, Rattner Z et al. (1993): Single photon emission tomography measurement of benzodiazepine receptor number and affinity in primate brain: a constant infusion paradigm with (123I)iomazenil. Eur J Pharmacology 230:119–123
Schlegel S, Schlößer R (to be published) Benzodiazepine receptor binding measured by IOMAZENIL-SPECT: Summary of different studies.
D’Haenen H, Bossuyt A, Mertens J, Bossuyt-Piron C, Gijsemans M, Kaufman L (1992) SPECT imaging of serotonin2 receptors in depression. Psychiatry Res 45:227–237
Jagust WJ, Eberlin JL, Roberts JA et al. (1993) In vivo imaging of the 5-hydroxytryptamine reuptake site in primate brain using single photon emission computed tomography and [123]5-iodo-6- nitroquipazine. Eur J Pharmacol 242:189–193
Holnian LB, Gibson RE, Hill TC, Eckelman WC, Albert MA, Reba RC (1985) Muscarinic acetylcholine receptors in Alzheimer’s disease. In vivo imaging with iodine 123-labeled 3-quinuclidinyl- 4-iodobezilate and emission tomography. JAMA 2254:3063–3066
Weinberger DR, Gibson R, Coppola R, Jones DW, Molchan S, Sunderland T, Ferman KF, Reba RC (1991) The distribution of cerebral muscarinic acetylcholine receptors in vivo in patients with dementia. Arch Neurol 48:169–176
Weinberger DR (1993) SPECT imaging in psychiatry: introduction and overview. J Clin Psychiatry 54[Suppl]:3–5
Müller-Gärtner HW, Wilson AA, Dannais RF, Wagner HN Jr, Frost J J (1992) Imaging muscarinic cholinergic receptors in human brain in vivo with SPECT [123]4-iododexetimide, and [123]4- iodolevetimide. J Cereb Blood Flow Metab 12:562–570
He XS, Bowen WD, Lee KS, Williams W, Weinberger DR, de Cost BR (1993) Synthesis and binding characteristics of potential SPECT imaging agents for sigma-1 and sigma-2 binding sites. J Med Chem 36:566–571
Garner SE, Kung MP, Foulon C, Chumpradit S, Kung HF (1994) [125](S)-trans-7-OH-PIPAT: a potential SPECT imaging agent for sigma binding sites. Life Sci 54:593–603
Bowen WD (1994) Sigma receptor-mediated cytotoxicity: sigma ligands produce changes in cell morphology and viability. Neuropsychopharmacology 10:836S
Shibuya H, Mori H, Toru M (1994) Sigma receptors in the postmortem schizophrenic brains. Neuropsychopharmacology 10:839S
Verhoeff NPLG (1991) Pharmacological implications for neuroreceptor imaging. Eur J Nucl Med 18:482–502
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Schlegel, S. (1995). Erwartungen des Psychiaters an die Rezeptoren-SPECT des Gehirns. In: Wieler, H.J. (eds) Single-Photon-Emissions-Computertomographie (SPECT) des Gehirns. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79222-9_7
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DOI: https://doi.org/10.1007/978-3-642-79222-9_7
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