Entwicklung und klinische Anwendung von Neurolite (Kit für die Herstellung von 99mTc-Bicisat)

  • F. Grünwald

Zusammenfassung

Xenon-133 erlaubt eine quantitative Messung der Hirndurchblutung; diese Methode hat aber einige Nachteile, die den Einsatz in der klinischen Routine erheblich erschweren. Neben den ungünstigen Eigenschaften des Isotops (lange Halbwertszeit, niedrige Gammaenergie) spielen dabei auch generelle Schwierigkeiten in der Handhabung von radioaktiven Gasen eine Rolle (insbesondere in bezug auf den Strahlenschutz).

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Literatur

  1. 1.
    Walovitch RC, Cheesman EH, Maheu LJ, Hall KM (1994) Studies of the retention of the brain perfusion imaging agent 99mTc-bicisate (99mTc-ECD). J Cereb Blood Flow Metab 14[Suppl 1]: 4–11Google Scholar
  2. 2.
    Walovitch RC, Hill TC, Garrity ST et al. (1989) Characterization of technetium-99m,L,L-ECD for brain perfusion imaging, part 1: pharmacology of technetium-99m ECD in nonhuman primates. J Nucl Med 30:1892–1901PubMedGoogle Scholar
  3. 3.
    Greenberg JH, Araki N, Karp A (1994) Correlation between 99mTc-bicisate and regional CBF measured with iodo-[14C]antipyrine in a primate focal ischemia model. J Cereb Blood Flow Metab 14[Suppl l]:36–43Google Scholar
  4. 4.
    Friberg L, Andersen AR, Lassen NA, Holm S, Dam M (1994) Retention of 99mTc-bicisate in the human brain after intracarotid injection. J Cereb Blood Flow Metab 14[Suppl 1]:19—27Google Scholar
  5. 5.
    Yonekura Y, Tsuchida T, Sadato N et al. (1994) Brain perfusion SPECT with 99mTc-bicisate: comparison with PET measurement and linearization based on permeability-surface area product model. J Cereb Blood Flow Metab 14[Suppl l]:58–65Google Scholar
  6. 6.
    Nakagawara J, Nakamura J, Takeda R et al. (1994) Assessment of postischemic reperfusion and diamox activation test in stroke using 99mTc-ECD SPECT. J Cereb Blood Flow Metab 14[Suppl 1]: 49–57CrossRefGoogle Scholar
  7. 7.
    Lassen NA, Sperling B (1994) 99mTc-bicisate reliably images CBF in chronic brain diseases but fails to show reflow hyperemia in subacute stroke: report of a multicenter trial of 105 cases comparing 133Xe and 99mTc-bicisate (ECD, Neurolite) measured by SPECT on same day. J Cereb Blood Flow Metab 14[Suppl l]:44–48Google Scholar
  8. 8.
    Moretti JL, Defer G, Cinotti L, Cesaro P, Vigneron N, Pethe C (1988) Comparative tomoscintigraphic study of strokes using ECD Tc-99m, HMPAO Tc-99m and IMP 1–123. Eur J Nucl Med 12:311Google Scholar
  9. 9.
    Griinwald F, Broich K, Hartmann A et al. (1993) Tc-99m-ECD brain SPECT in stroke: early and delayed scan. J Cereb Blood Flow Metab 13[Suppl 1]:348Google Scholar
  10. 10.
    Leveille J, Demonceau G, De Roo M et al. (1989) Characterization of technetium-99m-L,L-ECD for brain perfusion imaging, part 2: biodistribution and brain imaging in humans. J Nucl Med 30:1902- 1910PubMedGoogle Scholar
  11. 11.
    Matsuda H, Li YM, Higashi S et al. (1993) Comparative SPECT study of stroke using Tc-99m ECD, 1–123 IMP, and Tc-99m HMPAO. Clin Nucl Med 18:754–758PubMedCrossRefGoogle Scholar
  12. 12.
    Moretti JL, Defer G, Tamgac F, Weinmann P, Belin C, Cesaro P (1994) Comparison of brain SPECT using 99mTc-blcisate (L,L-ECD) and [123I]IMP in cortical and subcortical strokes. J Cereb Blood Flow Metab 14[Suppl l]:84–90Google Scholar
  13. 13.
    Brass LM, Walovitch RC, Joseph JL et al. (1994) The role of single photon emission computed tomography brain imaging with 99mTc-bicisate in the localization and definition of mechanisms of ischemic stroke. J Cereb Blood Flow Metab 14[Suppl l]:91–98Google Scholar
  14. 14.
    Waldemar G, Walovitch RC, Andersen AR et al. (1994) 99mTc-bicisate (Neurolite) SPECT brain imaging and cognitive impairment in dementia of the Alzheimer type: a blinded read of image sets from a multicenter SPECT trial. J Cereb Blood Flow Metab 14[Suppl 1]:99–105Google Scholar
  15. 15.
    Miletich RS, Quarantelli M, Di Chiro G (1994) Regional cerebral blood flow imaging with 99mTc- bicisate SPECT in asymmetric Parkinson’s disease: studies with and without chronic drug therapy. J Cereb Blood Flow Metab 14[Suppl 1]:106–114CrossRefGoogle Scholar
  16. 16.
    Griinwald F, Menzel C, Pavics L (1994) Ictal and interictal brain SPECT imaging in epilepsy using technetium-99m-ECD. J Nucl Med 35: 1896–1901Google Scholar
  17. 17.
    Yonekura Y, Sasaki Y, Kubo A, Tanada S, Momose T, Torizuka K (1993) Clinical usefulness of 99mTc-ECD - a multicenter phase 3 study. Kaku Igaku 30:397–410PubMedGoogle Scholar
  18. 18.
    Holm S, Madsen L, Sperling B, Lassen NA (1994) Use of 99mTc-bicisate in activation studies by split- dose technique. J Cereb Blood Flow Metab 14[Suppl 1]:115–120Google Scholar

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© Springer-Verlag Berlin Heidelberg 1995

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  • F. Grünwald

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