Zusammenfassung
Degenerative Krankheiten des Gehirns sind durch einen fortschreitenden Verlust an Nervenzellen gekennzeichnet; dieser betrifft zumindest initial nicht diffus das gesamte Gehirn, sondern beschränkt sich auf je nach Krankheit verschiedene Anteile der grauen Substanz [1, 2]. Die Ursache des Neuronenverlustes ist bei den meisten dieser Krankheiten bisher ungeklärt. Neuropathologisch findet sich in den Anfangsstadien eine Verminderung der regionalen Nervenzelldichte, die bei ihrem Fortschreiten zur Verringerung des Volumens der beteiligten zerebralen Strukturen, zur sog. Atrophie, führt.
Bei Frau Dr. med. Cornelia Puskas (Klinik und Poliklinik für Nuklearmedizin, WWU Münster) bedanke ich mich für die wiederholte kritische Durchsicht des Manuskriptes. Frau Papenberg (Klinik und Poliklinik für Nuklearmedizin, WWU Münster) und Herrn Dr. med. Norbert Czech (Institut für Medizin, KFA Jülich) gilt mein Dank für die Mithilfe bei der Erstellung der Abbildungen.
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Kuwert, T. (1995). SPECT-Untersuchungen bei degenerativen Krankheiten des Gehirns. In: Wieler, H.J. (eds) Single-Photon-Emissions-Computertomographie (SPECT) des Gehirns. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79222-9_13
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