Growth Stimulation Mediated by G Protein Coupled Receptors in Hepatocytes: Synergism with Epidermal Growth Factor and Mechanisms of Signal Transduction

  • Thoralf Christoffersen
  • G. Hege Thoresen
  • Olav F. Dajani
  • Dagny Sandnes
  • Magne Refsnes
Conference paper
Part of the NATO ASI Series book series (volume 88)


Hepatocyte proliferation is stimulated not only by mitogenic growth factors through tyrosine kinase receptors, but also by a number of other hormonal agents, most of which exert their effects via G protein-coupled receptors. Although factors in the latter category usually seem to act permissively rather than as complete, independent, hepatic mitogens, the magnitude of their effects may under optimal conditions be quite substantial. A more precise understanding of how their signals are mediated and integrated with the actions of mitogenic growth factors in hepatocytes may yield insights into mechanisms of both hepatic and general growth regulation.


Adenylyl Cyclase Growth Effect Pertussis Toxin Hepatocyte Proliferation Glucagon Receptor 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Thoralf Christoffersen
    • 1
  • G. Hege Thoresen
    • 1
  • Olav F. Dajani
    • 1
  • Dagny Sandnes
    • 1
  • Magne Refsnes
    • 1
  1. 1.Department of Pharmacology, Faculty of MedicineUniversity of OsloOsloNorway

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