Abstract
Hepatocyte growth factor (HGF) (Nakamura et al., 1987; Gohda et al., 1988), also designated as scatter factor (Gherardi et al., 1989) or fibroblast-derived tumor cytotoxic factor (Higashio et al., 1990), is a heparin-binding basic protein with an approximate molecular mass of 80 kD. HGF is a disulfide-linked heterodimer composed of an a-chain of 52–56 kD and a β-chain of 30–34 kD. Recent studies have revealed that HGF not only functions as a mitogen for hepatocytes, it also stimulates the growth of various epithelial and endothelial cells (Rubin et al., 1991); it inhibits the growth of tumor cells (Higashio et al., 1990; Shima et al., 1991a); and it stimulates the mobility of epithelial (Gherardi et al., 1989) and endothelial cells (Rosen et al., 1990).
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© 1994 Springer-Verlag Berlin Heidelberg
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Shima, N., Higashio, K. (1994). Hepatocyte Growth Factor and Its Variant with a Deletion of Five Amino Acids are Distinguishable in Biological, Physicochemical, and Immunochemical Properties. In: Skouteris, G.G. (eds) Liver Carcinogenesis. NATO ASI Series, vol 88. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79215-1_4
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DOI: https://doi.org/10.1007/978-3-642-79215-1_4
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