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Liver Carcinogenesis pp 389–409Cite as

Isolation and Growth of Hepatocytes and Biliary Epithelial Cells from Normal and Diseased Human Livers

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Part of the book series: NATO ASI Series ((ASIH,volume 88))

Abstract

The regulation of mammalian liver regeneration is complex. From both experimental animal studies and the use of isolated hepatocytes, numerous hormones, nutrients and growth factors have been implicated (Bucher and Strain, 1992). In keeping with all mammals, the human liver regenerates following resection or injury. More recently with the advent of liver transplantation, other situations where human liver growth occurs have also become pertinent. For example, organs from younger donors transplanted into larger, older recipients enlarge to the correct organ size for body weight (Van Thiel et al., 1987) and segmental grafts also regenerate with growth and development in pediatric recipients (Emond et al., 1989). The factors which control these responses in man are not well understood.

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Author information

Authors and Affiliations

  1. Liver Units, Queen Elizabeth Hospital and Children’s Hospital and School of Biochemistry, University of Birmingham, Edgbaston, Birmingham, UK

    Alastair J. Strain, Lorraine Wallace, Ruth Joplin, James Neuberger & Deirdre Kelly

Authors
  1. Alastair J. Strain
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  2. Lorraine Wallace
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  3. Ruth Joplin
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  4. James Neuberger
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  5. Deirdre Kelly
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Editor information

Editors and Affiliations

  1. Department of Applied Tumor Virology, Laboratory of Virus-Host Cell Interactions, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, D-69120, Heidelberg, Germany

    George G. Skouteris

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© 1994 Springer-Verlag Berlin Heidelberg

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Strain, A.J., Wallace, L., Joplin, R., Neuberger, J., Kelly, D. (1994). Isolation and Growth of Hepatocytes and Biliary Epithelial Cells from Normal and Diseased Human Livers. In: Skouteris, G.G. (eds) Liver Carcinogenesis. NATO ASI Series, vol 88. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79215-1_24

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  • DOI: https://doi.org/10.1007/978-3-642-79215-1_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79217-5

  • Online ISBN: 978-3-642-79215-1

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