Isolation and Growth of Hepatocytes and Biliary Epithelial Cells from Normal and Diseased Human Livers

  • Alastair J. Strain
  • Lorraine Wallace
  • Ruth Joplin
  • James Neuberger
  • Deirdre Kelly
Conference paper
Part of the NATO ASI Series book series (volume 88)


The regulation of mammalian liver regeneration is complex. From both experimental animal studies and the use of isolated hepatocytes, numerous hormones, nutrients and growth factors have been implicated (Bucher and Strain, 1992). In keeping with all mammals, the human liver regenerates following resection or injury. More recently with the advent of liver transplantation, other situations where human liver growth occurs have also become pertinent. For example, organs from younger donors transplanted into larger, older recipients enlarge to the correct organ size for body weight (Van Thiel et al., 1987) and segmental grafts also regenerate with growth and development in pediatric recipients (Emond et al., 1989). The factors which control these responses in man are not well understood.


Hepatocyte Growth Factor Human Liver Primary Biliary Cirrhosis Primary Sclerosing Cholangitis Human Hepatocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Alastair J. Strain
    • 1
  • Lorraine Wallace
    • 1
  • Ruth Joplin
    • 1
  • James Neuberger
    • 1
  • Deirdre Kelly
    • 1
  1. 1.Liver Units, Queen Elizabeth Hospital and Children’s Hospital and School of BiochemistryUniversity of BirminghamBirminghamUK

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