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Kompendium Internistische Onkologie pp 53–85Cite as

Prinzipien der Tumorimmunologie

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Zusammenfassung

Die Entstehung von Tumoren stellt einen multifaktoriellen Prozeß dar, der durch die sequentielle Akkumulation verschiedener genetischer Ereignisse charakterisiert ist. Dies wurde insbesondere durch Arbeiten von Vogelstein und Koautoren belegt, die bei der Entstehung von Dickdarmkarzinomen verschiedene genetische Mechanismen im Verlauf der Adenom-Karzinom-Sequenz beschrieben (Vogelstein et al. 1988; Vogelstein u. Kinzler 1992). Die Aktivierung von Onkogenen und die Inaktivierung von Tumorsuppressorgenen sind Mechanismen, die für die zelluläre Transformation von Bedeutung sind, wobei chemische, virale und physikalische Karzinogene als Auslöser dieser Mechanismen angesehen werden. Untersuchungen der letzten 20 Jahre deuten auf komplexe Interaktionen zwischen Tumorzellen und dem Immunsystem hin. Durch das wachsende Verständnis der molekularen Vorgänge von Zelloberflächenveränderungen auf Tumorzellen und der Charakterisierung von murinen tumorspezifischen Transplantationsantigenen (TSTA) sowie menschlichen Tumorantigenen hat sich der Wissensstand der zellulären Immunreaktionen gegenüber Tumoren und über die Mechanismen von Tumorzellen, sich dem Immunsystem zu entziehen, deutlich verbessert.

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Authors
  1. B. Seliger
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  2. C. Huber
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Editors and Affiliations

  1. Klinik für Hämatologie/Onkologie, Martin-Luther-Universitä Halle-Wittenberg, Ernst-Grube-Straße 40, 06120, Halle/Saale, Deutschland

    Hans-Joachim Schmoll

  2. Klinik und Poliklinik für Innere Medizin II, Klinikum der Friedrich-Schiller-Universität Jena, Erlanger Allee 101, 07740, Jena, Deutschland

    Klaus Höffken

  3. Medizinischen Klinik II Schwerpunkt Onkologie und Hämatologie, Humboldt-Universität, Universitätsklinikum Charité, Schumannstraße 20/21, 10117, Berlin, Deutschland

    Kurt Possinger (Direktor) (Direktor)

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Seliger, B., Huber, C. (1996). Prinzipien der Tumorimmunologie. In: Schmoll, HJ., Höffken, K., Possinger, K. (eds) Kompendium Internistische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79214-4_2

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