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Zytokine und ihre Bedeutung für Wundheilungsprozesse

  • T. Luger
Conference paper
Part of the Fortschritte der operativen und onkologischen Dermatologie book series (OP.DERMATOLOGIE, volume 8)

Zusammenfassung

Unter dem Begriff Zytokine versteht man Mediatoren, die unter normalen Bedingungen sowie im Verlauf von pathologischen Vorgängen Zellfunktionen regulieren und neuerdings auch zu Therapiezwecken eingesetzt werden. Zytokine werden von allen Zellen des Organismus gebildet und üben vielfältige, teilweise synergistische oder antagonistische Wirkungen aus, so daß die Existenz eines komplexen Netzwerkes angenommen werden muß. Im Rahmen der multiplen Vorgänge der Wundheilung bestehend aus Entzündungsreaktion und Gewebserneuerung spielen Zytokine eine entscheidende Rolle. Diese Mediatoren können von allen am Wundheilungsgeschehen beteiligten Zellen gebildet werden, wobei deren Synthese und Freisetzung durch Mikroorganismen, Matrixproteine und Zytokine selbst geregelt wird. Während Interleukine vorwiegend den Ablauf der Entzündungsreaktion beeinflussen, steuern Wachstumsfaktoren hauptsächlich Fibroplasie, Gewebserneuerung und Reepithelisierung. Die wichtige Rolle von Zytokinen im Rahmen der Wundheilung ist auch schon durch erste vielversprechende Ergebnisse bei deren Anwendung zur Behandlung von schlecht heilenden Wunden dokumentiert.

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Literatur

  1. 1.
    Adolf GR, Grell M, Scheurich P (1993) Tumor necrosis factor. In: Luger TA, Schwarz T (eds) Epidermal cytokines and growth factors. Dekker, New York, pp 63–88Google Scholar
  2. 2.
    Balkwill FR, Burke F (1989) The cytokine network [see comments]. Immunol Today 10: 299–304PubMedCrossRefGoogle Scholar
  3. 3.
    Beutler B, Cerami A (1990) Cachectin (tumor necrosis factor), an endogenous mediator of shock and inflammatory response. In: Oppenheim JJ, Shevach EM (eds) Immunophysiology; the role of cells and cytokines in immunity and inflammation. Oxford University Press, NewYork, pp 226–237Google Scholar
  4. 4.
    Clark RAF, Hensan PM (1988) The molecular and cellular biology of wound repair. Plenum, New York LondonGoogle Scholar
  5. 5.
    Coffman RL, O’Garra A, Volkmann D (1990) Interleukins and interferons acting on Blymphocytes. In: Oppenheim J J, Shevach EM (eds) Immunophysiology; the role of cells and cytokines in immunity and inflammation. Oxford University Press, New York, pp 88–103Google Scholar
  6. 6.
    Dinarello CA (1989) Interleukin-1 and its biologically related cytokines. Adv Immunol 44: 153–205PubMedCrossRefGoogle Scholar
  7. 7.
    Dinarello CA, Thompson RC (1991) Blocking IL-1: Interleukin 1 receptor antagonist in vivo and in vitro. Immunol Today 12: 404–410PubMedCrossRefGoogle Scholar
  8. 8.
    Durum SK, Oppenheim JJ, Neta R (1990) Immunophysiologic role of interleukin–1. In: Oppenheim JJ, Shevach EM (eds) Immunophysiology; the role of cells and cytokines in immunity and inflammation. Oxford University Press, New York, pp 210–225Google Scholar
  9. 9.
    Ebendal T (1992) Function and evolution in the NGF family and its receptors. J Neurosci Res 32: 461–470PubMedCrossRefGoogle Scholar
  10. 10.
    Elder JT (1993) Transforming growth factor alpha and related factors: In: Luger TA, Schwarz T (eds) Epidermal cytokines and growth factors. Dekker, New York, pp 205–240Google Scholar
  11. 11.
    Friedmann RM (1990) Interferons. In: Oppenheim JJ, Shevach EM (eds) Immunophysiology; the role of cells and cytokines in immunity and inflammation. Oxford University Press, New York, pp 194–209Google Scholar
  12. 12.
    Gately MK, Desai BB, Wolitzky AG, Quinn PM, Dwyer CM, Podlaski FJ, Familletti PC, Sinigaglia F, Chizonnite R, Gubler U et al. (1991) Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL–12 (cytotoxic lymphocyte maturation factor). J Immunol 147: 874–882PubMedGoogle Scholar
  13. 13.
    Halaban R, Moellmann G (1993) Fibroblast growth factor. In: Luger TA, Schwarz T (eds) Epidermal cytokines and growth factors. Dekker, New York, pp 273–289Google Scholar
  14. 14.
    Henney CS (1990) Interleukin 7: effects of early events in lymphopoiesis. Immunol Today 10: 170–173CrossRefGoogle Scholar
  15. 15.
    Howard M, O’Garra A (1992) Biological properties of interleukin 10. Immunol Today 13: 198–200PubMedCrossRefGoogle Scholar
  16. 16.
    Kaczmarski RS, Mufti GJ (1991) The cytokine receptor superfamily. Blood 5: 193–203CrossRefGoogle Scholar
  17. 17.
    Luger TA, Trautinger F, Schwarz T (1993) Cytokines-Therapeutic aspects for skin diseases. In: Luger TA, Schwarz T (eds) Epidermal cytokines and growth factors. Dekker, New York, pp 453–473Google Scholar
  18. 18.
    Massague J (1987) The TGF-beta family of growth and differentiation factors. Cell 49: 437–438PubMedCrossRefGoogle Scholar
  19. 19.
    Matsushima K, Oppenheim J J (1989) Interleukin 8 and MCAF: novel inflammatory cytokines inducible by EL 1 and TNF. Cytokine 1: 2–13PubMedCrossRefGoogle Scholar
  20. 20.
    Mauch C, Oono T, Eckes B, Krieg T (1993) Cytokines and wound healing. In: Luger TA, Schwarz T (eds) Epidermal cytokines and growth factors. Dekker, New York, pp 325–344Google Scholar
  21. 21.
    McKay IA, Leigh IM (1991) Epidermal cytokines and their roles in cutaneous wound healing. Br J Dermatol 124: 513–518PubMedCrossRefGoogle Scholar
  22. 22.
    Metealf D (1990) The colony stimulating factors. Discovery, development, and clinical applications. Cancer 65: 2185–2195CrossRefGoogle Scholar
  23. 23.
    Miyajima A, Kitamura T, Harada N, Yokota T, Arai K (1992) Cytokine receptors and signal transduction. Annu Rev Immunol 10: 295–331PubMedCrossRefGoogle Scholar
  24. 24.
    Moore MAS (1988) Interleukin-3, an overview: In: Schräder JW (ed) Lymphokines, vol 15. Academic Press, San Diego, p 219Google Scholar
  25. 25.
    O’Garra A (1989) Interleukins and the immune system 1. Lancet 1: 943–947PubMedGoogle Scholar
  26. 26.
    Paul SR, Schendel P (1992) The cloning and biological characterization of recombinant human interleukin 11. Int J Cell Cloning 10: 134–142Google Scholar
  27. 27.
    Pestka S (1993) The interferons. In: Luger TA, Schwarz T (eds) Epidermal cytokines and growth factors. Dekker, New York, pp 163–201Google Scholar
  28. 28.
    Renauld JC, Goethals A, Houssiau F, Merz H, Van Roost E, Van Snick J (1990) Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene. J Immunol 144: 4235–4241PubMedGoogle Scholar
  29. 29.
    Ross R (1989) Platelet-derived growth factor. Lancet 1: 1179–1182PubMedCrossRefGoogle Scholar
  30. 30.
    Rothe M, Falanga V (1989) Growth factors. Their biology and promise in dermatologic disease and tissue repair. Arch Dermatol 125: 1390–1398Google Scholar
  31. 31.
    Rotwein P (1991) Structure, evolution, expression and regulation of insulin–like growth factors I and II. Growth Factors 5: 3–18PubMedCrossRefGoogle Scholar
  32. 32.
    Ruscetti FW (1990) Interleukin-2. In: Oppenheim JJ, Shevach EM (eds) Immunophysiology; the role of cells and cytokines in immunity and inflammation. Oxford University Press, New York, pp 46–66Google Scholar
  33. 33.
    Sanderson CJ, Campbell HD, Young Ig (1988) Molecular and cellular biology of eosinophil differentiation factor (interleukin–5) and its effects on human and mouse B cells. Immunol Rev 102: 29–50PubMedCrossRefGoogle Scholar
  34. 34.
    Schräder JW (1993) Colony stimulating factors and the skin. In: Luger TA, Schwarz T (eds) Epidermal cytokines and growth factors. Dekker, New York, pp 147–162Google Scholar
  35. 35.
    Schröder JM (1992) Chemotactic cytokines in the epidermis. Exp Derm 1: 12–19PubMedCrossRefGoogle Scholar
  36. 36.
    Schwarz T, Luger TA (1992) Pharmacology of cytokines in the skin. In: Muhktar H (ed) Pharmacology of the skin. CRC Press, Boca Raton, pp 283–314Google Scholar
  37. 37.
    Sehgal PB (1990) Interleukin-6: molecular pathophysiology. J Invest Dermatol 94: 2S–6SPubMedCrossRefGoogle Scholar
  38. 38.
    Taniguchi T (1992) Structure and function of IL-2 and IL-2 receptors. Behring Inst Mitt 91: 87–95PubMedGoogle Scholar
  39. 39.
    Wong GG, Clark SC (1988) Multiple actions of interleukin 6 within a cytokine network. Immunol Today 9: 137–139PubMedCrossRefGoogle Scholar
  40. 40.
    Yokota T, Arai N, de Vries J, Spits H, Banchereau J, Zlotnik A, Rennick D, Howard M, Takebe Y, Miyatake S et al. (1988) Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells. Immunol Rev 102: 137–187Google Scholar

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© Springer-Verlag Berlin Heidelberg 1994

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  • T. Luger

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