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Biological Mechanisms and Toxicological Consequences of the Methylation of Arsenic

  • Chapter
Book cover Toxicology of Metals

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 115))

Abstract

Since ancient times, arsenic (As) has been recognized as an agent with potent biological effects (FRost 1967). Both Hippocrates and Galen described the medicinal use of As-containing sulfides and oxides (BUchanan 1962). In the era before penicillin, the antibiotic potency of organic As (organoAs) compounds made them an important part of the pharmaceutical armamentarium (GOodman and GIlman 1941). The potent toxicity of As results in its continued use as a component of insecticides, herbicides, and rodenticides and as a wood preservative. As has long been used in glass-making, and As-containing semiconductors will likely play an increasingly large role in electronics manufacture.

The first two authors contributed equally to the preparation of this review. This manuscript has been reviewed in accordance with the policy of the Health Effects Research Laboratory, United States Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use.

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Authors
  1. M. Styblo
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  2. M. Delnomdedieu
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  3. D. J. Thomas
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Editors and Affiliations

  1. Department of Pathology, University of Western Ontario, N6A 5C1, Ontario, Canada

    Robert A. Goyer M.D. (Professor Emeritus) & M. George Cherian Ph.D. (Professor) (Professor Emeritus) &  (Professor)

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© 1995 Springer-Verlag Berlin Heidelberg

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Styblo, M., Delnomdedieu, M., Thomas, D.J. (1995). Biological Mechanisms and Toxicological Consequences of the Methylation of Arsenic. In: Goyer, R.A., Cherian, M.G. (eds) Toxicology of Metals. Handbook of Experimental Pharmacology, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79162-8_18

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  • DOI: https://doi.org/10.1007/978-3-642-79162-8_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79164-2

  • Online ISBN: 978-3-642-79162-8

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