Biological Mechanisms and Toxicological Consequences of the Methylation of Arsenic

  • M. Styblo
  • M. Delnomdedieu
  • D. J. Thomas
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 115)


Since ancient times, arsenic (As) has been recognized as an agent with potent biological effects (FRost 1967). Both Hippocrates and Galen described the medicinal use of As-containing sulfides and oxides (BUchanan 1962). In the era before penicillin, the antibiotic potency of organic As (organoAs) compounds made them an important part of the pharmaceutical armamentarium (GOodman and GIlman 1941). The potent toxicity of As results in its continued use as a component of insecticides, herbicides, and rodenticides and as a wood preservative. As has long been used in glass-making, and As-containing semiconductors will likely play an increasingly large role in electronics manufacture.


Urinary Excretion Inorganic Arsenic Arsenic Trioxide Dimethylarsinic Acid Marmoset Monkey 
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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • M. Styblo
  • M. Delnomdedieu
  • D. J. Thomas

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