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Metals and Stress Proteins

  • P. L. Goering
  • B. R. Fisher
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 115)

Abstract

Prokaryotic and eukaryotic cells respond to physical and chemical stressors or stress by increasing the transcription of specific genes that encode for a small class of proteins termed heat shock proteins (hsps). This response is believed to represent a transient reprogramming of gene expression and biological activity which serves to protect sensitive cellular components from irreversible damage and assists in the rapid recovery after the stress is removed or ceases. The changes in gene expression associated with this response following exposure to a stimulus are rapid, and result in both increased de novo synthesis and accumulation of stress proteins. Originally termed the heat shock response because of the induction of these proteins following hyperthermia (RItossa 1962), the signaling mechanism involved in its initiation is sensitive to a variety of physical and chemical insults, including metals (NOver 1991). Because the response can be initiated by a variety of stressors it is generically referred to as the “stress response.” In this review, for convention and to avoid confusion, we have adopted the use of the term “stress proteins” when referring to classic hsps and other stress proteins. Therefore, the hsps will be considered as a subset of the stress proteins, and reference to hsps will be used only when deemed necessary, e.g., when referring to specific references and studies describing specific hsps.

Keywords

Heat Shock Heat Shock Protein Heme Oxygenase Stress Protein Heat Shock Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • P. L. Goering
  • B. R. Fisher

There are no affiliations available

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