Zusammenfassung
Die chronische UV-Exposition hat wesentliche Aus wirkungen auf Epidermis und Dermis. Während die UVB-Exposition hauptsächlich zu epithelialen Tu moren führt, ist die UVA-Strahlung, aber auch Teile der UVB-Strahlung für die sogenannte Photoalterung der Dermis verantwortlich. Obwohl diese extrinsische Alterung durch den intrinsischen Alterungsprozeß überlagert wird, lassen sich beide jedoch gegeneinander abgrenzen (Tabelle 1). Dabei werden sowohl einzelne Zelltypen als auch Struktur proteine der Dermis verändert. Wahrscheinlich kommt es darüber hinaus zu komplexen Störungen, die Zell-Zell-Interaktionen involvieren.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Anttinen H, Orava S, Ryhänen L, Kivirikko KI (1973) Assay of protocollagen lysine hydroxylase in the skin of human subjects and changes in the activity with age. Clin Chim Acta 47:28.
Anttinen H, Oikarinen A, Kivirikko KI (1977) Age-re lated changes in human skin collagen galactosyltransferase and collagen glucosyltransferase activities. Clin Chim Acta 76:95.
Bayreuther K, Francz PI (1990) Aging in the human dermal fibroblast stem cell system in vivo and in vitro. Molecular biology of aging. Alan Liss, New York pp 205–215.
Bayreuther K, Rodemann HP, Hommel R, Dittmann K, Albiez M (1988) Human skin fibroblasts in vitro diffe rentiate along a terminal cell lineage. Proc Natl Acad Sci USA 85:5112–5116.
Gilchrest BA (1984) Age-associated changes in normal skin. In: Skin and aging processes. CRC, Boca Raton, PP 17–35.
Krieg T, Hein R, Hatamochi A, Aumailley M (1988) Molecular and clinical aspects of connective tissue. Eur J Clin Invest 18:105–123.
Miyahara T, Shiozawa S, Murai A (1990) The effect of age on amino acid composition of human skin colla gen. J Gerontol 33:498.
Monagna W, Kirchner S, Carlisle K (1989) Histology of sundamaged human skin. J Am Acad Dermatol 21:907–918.
Muggleton-Harris AL, Reisert PS, Burghoff RL (1982) In vitro characterization of response to stimulus (wounding) with regard to ageing in human skin fi broblasts. Mech Ageing Dev 19:37–43.
Oxholm A, Oxholm P, Staberg B, Bendtzen K (1988) Immunohistological detection of interleukin I-like molecules and tumour necrosis factor in human epi dermis before and after UVB-irradiation in vivo. Br J Dermatol 118:369–376.
Scharffetter K, Wlaschek M, Hogg A et al. (1991) UVA irradiation induces collagenase in human dermal fi broblasts in vitro and in vivo. Arch Dermatol Res 283:506–511.
Schwarz T, Luger TA (1989) Effect of UV-irradiation on epidermal cell cytokine production. J Photochem Photobiol 4:1–13.
Tuderman L, Kivirikko KI (1977) Immunoreactive prolyl hydroxylase in human skin, serum, synovial fluid. Changes in the content and components with age. Eur J Clin Invest 7:295.
Uitto J (1986) Connective tissue biochemistry of the aging dermis. Age-related alterations in collagen and elastin. Dermatol Clin 4:433–446.
Uitto J (1989) Connective tissue biochemistry of the aging dermis. Age-associated alterations in collagen and elastin. Clin Geriatric Med 5:127–146.
Van der Rest M, Garrone R (1991) Collagen family of proteins. FASEB J 5:2814–2823.
Wlaschek M, Herrmann G, Bolsen K et al. (1991) Mole cular mechanisms of cutaneous photoaging. Aging and cellular defense mechanisms (The New York Aca demy of Science, Modena 22.-26.9.1991).
Wlaschek M, Bolsen K, Herrmann G et al. (in press) UV-A induced stimulation of fibroblast-derived-collagenase by IL-6. A possible mechanism in dermal photodamage? J Invest Dermatol.
Yurchenco PD, Schittny JC (1990) Molecular architec ture of basement membranes. FASEB ] 4:1577–1590.
Ziegler-Heitbrock HW, Krieg T (1989) Synergistic ef fect of tumor necrosis factor-a and interferon-gamma on collagen synthesis of human fibroblast in vitro. Exp Cell Res 181:409–419.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Scharffetter-Kochanek, K., Krieg, T. (1995). Lichtalterung. In: Plewig, G., Korting, H.C. (eds) Fortschritte der praktischen Dermatologie und Venerologie. Fortschritte der praktischen Dermatologie und Venerologie, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79156-7_28
Download citation
DOI: https://doi.org/10.1007/978-3-642-79156-7_28
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-79157-4
Online ISBN: 978-3-642-79156-7
eBook Packages: Springer Book Archive