Dopaminergic Drugs in Cardiovascular Emergencies
Drugs acting at dopamine (DA) receptors provide an important therapeutic approach in the treatment of various cardiovascular emergencies [1–3]. Peripheral dopamine receptors are classified into two distinct subtypes, namely DA-1 and DA-2 [1–3]. Whereas DA, in addition to stimulating both DA-1 and DA-2 receptors, also activates α- and β-adrenoceptors, there are compounds available which preferentially activate either DA-1 and/or DA-2 receptors and do not stimulate a- and β-adrenoceptors. The major cardiovascular consequence following stimulation of DA receptors include decreases in cardiac afterload or peripheral vascular resistance, increases in cardiac index, mesenteric and renal blood flows as well as natriuresis and diuresis. The dopaminergic drugs currently available for the treatment of cardiovascular emergencies include dopamine, fenoldopam and dopexamine.
KeywordsCardiac Index Renal Blood Flow Hemorrhagic Shock Mean Blood Pressure Dopaminergic Drug
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