Endothelial Modulation of Myocardial Contraction: a Novel Cardioregulatory Mechanism?
The vascular endothelium consists of a monolayer of cells forming a continuous lining of all blood vessels (with the exception of the spleen). As such, it is in intimate contact with every tissue and is thus in a prime position to exert influence over organ function. The heart contains two types of endothelial cells; vascular and endocardial. Although similar, they show both anatomical and functional differences . The myocardium is richly vascularized, and it has been estimated that any cardiac myocyte is only a few microns away from a capillary vascular endothelial cell. Endocardial endothelial cells (EEC), by contrast, line the cardiac cavities and are in close contact with a relatively small mass of myocardium.
KeywordsNitric Oxide Nitric Oxide Papillary Muscle Sodium Nitroprusside Myocardial Contraction
Unable to display preview. Download preview PDF.
- 3.Shah AM (1994) Modulation of myocardial contractile function by endothelium. In: Haunso S, Kjeldsen K (eds) International Society for Heart Research. Monduzzi Editore, Bologna, pp 53–60Google Scholar
- 6.Grocott-Mason R, Anning P, Evans H, Lewis MJ, Shah AM (1995) Modulation of left ventricular relaxation in the isolated ejecting heart by endogenous nitric oxide. Am J Physiol (in press)Google Scholar
- 26.Evans H, Lewis MJ, Shah AM (1995) Modulation of myocardial relaxation by basal release of endothelin from endocardial endothelium. Cardiovasc Res (in press)Google Scholar
- 36.Anning P, Grocott-Mason R, Lewis MJ, Shah AM (1994) Adenyl purines contribute to the myocardial relaxant effects of bradykinin in the intact heart. Br Heart J 71 (Suppl): P48 (Abst)Google Scholar
- 40.Shah AM, Mebazaa A, Wetzel RC, Lakatta EG (1994) Novel cardiac myofilament desensitising factor released by endocardial and vascular endothelial cells. Circ Res 89: 2492–2497Google Scholar
- 41.Pepper CB, Lewis MJ, Shah AM (1995) Endothelial regulation of cardiac myocyte contraction by modulation of Ca2+-myofilament interaction. Circulation (Suppl): (Abst) (in press)Google Scholar