Abstract
In 1980, Furchgott and Zawadski [1] first reported “the obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine”. It is now well established that endothelium-dependent vasorelaxation is mainly mediated by the release of nitric oxide (NO) or an NO-releasing agent (also known as endothelium-derived relaxing factor, EDRF) and prostacyclin. Endothelium-dependent vasocontriction can be produced by endothelin or constrictor prostanoids, although the inhibition of NO release may also be implicated.
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References
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© 1995 Springer-Verlag Berlin Heidelberg
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Mebazaa, A., Shah, A.M. (1995). “Obligatory” Role of Endothelial Cells in Regulating Myocardial Contraction?. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 1995. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79154-3_40
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DOI: https://doi.org/10.1007/978-3-642-79154-3_40
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