Advertisement

Pulmonary Dysfunction after Remote Ischemia and Reperfusion

  • A. B. J. Groeneveld
  • P. G. H. Raijmakers
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1995)

Abstract

Ischemia/reperfusion (I/R) is a common clinical event. It may occur during (gastrointestinal or traumatic/surgical) hemorrhage and resuscitation, during/after vascular surgery, cardiopulmonary bypass, thrombolytic therapy for myocardial infarction and transplantation surgery [1]. Indeed, the transplantation of organs like the heart, lungs and kidneys is associated with I/R, and specific measures for organ preservation are meant to prevent such I/R damage.

Keywords

Cardiopulmonary Bypass Hemorrhagic Shock Adult Respiratory Distress Syndrome Aortic Surgery Microvascular Permeability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Korthuis RJ, Anderson DC, Granger DN (1994) Role of neutrophil-endothelial cell adhesion in inflammatory disorders. J Crit Care 9: 47–71PubMedCrossRefGoogle Scholar
  2. 2.
    Fowler AA, Hamman RF, Good JT, et al (1983) Adult respiratory distress syndrome: Risk with common predispositions. Ann Intern Med 98: 593–597PubMedGoogle Scholar
  3. 3.
    Westaby S (1987) Organ dysfunction after cardiopulmonary bypass. A systemic inflammatory reaction initiated by the extracorporeal circuit. Intensive Care Med 13: 89–95PubMedCrossRefGoogle Scholar
  4. 4.
    Bernard GR, Artigas A, Brigham KL, et al (1994) The American-European consensus conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 149: 818–824PubMedGoogle Scholar
  5. 5.
    Granger DN (1988) Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol 255: H1269–H1275PubMedGoogle Scholar
  6. 6.
    Colletti LM, Remick DG, Burtch GD, Kunkel SL, Streiter RM, Campbell DA (1990) Role of tumor necrosis factor alpha in the pathophysiologic alterations following hepatic ischemia/reperfusion injury in the rat. J Clin Invest 85: 1936–1943PubMedCrossRefGoogle Scholar
  7. 7.
    Hill J, Lindsay TF, Ortiz F, Yeh CG, Hechtman HB, Moore FD (1992) Soluble complement receptor type 1 ameliorates the local and remote organ injury after intestinal ischemia/reperfusion in the rat. J Immunol 149: 1723–1728PubMedGoogle Scholar
  8. 8.
    Terada LS, Dormish JJ, Shanley PF, Leff JA, Anderson BO, Repine JE (1992) Circulating xanthine oxidase mediates lung neutrophil sequestration after intestinal ischemia/reperfusion. Am J Physiol 263: L394–L401PubMedGoogle Scholar
  9. 9.
    Poggetti RS, Moore FA, Moore EE, Bensard DD, Anderson BO, Banerjee A (1992) Liver injury is a reversible neutrophil-mediated event following gut ischemia. Arch Surg 127: 175–179PubMedCrossRefGoogle Scholar
  10. 10.
    Hill J, Lindsay TF, Hechtman HB (1992) Mediators of lung injury following ischemia and reperfusion. In: Lamy M, Thijs LG (eds). Update in intensive care and emergency medicine, Volume 16: Mediators of sepsis. Springer Verlag, Berlin, pp 31–50Google Scholar
  11. 11.
    Schoenberg MH, Beger HG (1993) Reperfusion injury after intestinal ischemia. Crit Care Med 21: 1376–1386PubMedCrossRefGoogle Scholar
  12. 12.
    Lefer AM, Weyrich AS, Buerke M (1994) Role of selectins, a new family of adhesion molecules, in ischaemia/reperfusion injury. Cardiovasc Res 28: 289–294PubMedCrossRefGoogle Scholar
  13. 13.
    Vedder NB, Fouty BW, Winn RK, Harlan JM, Rice CL (1989) Role of neutrophils in generalized reperfusion injury associated with resuscitation from shock. Surgery 106: 509–516PubMedGoogle Scholar
  14. 14.
    Anderson BO, Moore EE, Moore FA, et al (1991) Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism. J Appl Physiol 71: 1862–1865PubMedGoogle Scholar
  15. 15.
    Roumen RHM, Hendriks T, Van der Ven-Jongekrijg J, et al (1993) Cytokine patterns in patients after major vascular surgery, hemorrhagic shock and severe blunt trauma. Ann Surg 218: 769–776PubMedCrossRefGoogle Scholar
  16. 16.
    Hoch RC, Rodriguez R, Manning T, et al (1993) Effects of accidental trauma upon cytokine and endotoxin production. Crit Care Med 21: 839–845PubMedCrossRefGoogle Scholar
  17. 17.
    Donnelly TJ, Meade P, Jagels M, et al (1994) Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury. Crit Care Med 22: 768–776PubMedCrossRefGoogle Scholar
  18. 18.
    Wortel CH, Van Deventer SJH, Aarden LA, et al (1993) Interleukin-6 mediates host defense responses induced by abdominal surgery. Surgery 114: 564–570PubMedGoogle Scholar
  19. 19.
    Anyanwu E, Ditrich H, Gieseking R, Enders HJ (1982) Ultrastructural changes in the human lung following cardiopulmonary bypass. Basic Res Cardiol 77: 309–322PubMedCrossRefGoogle Scholar
  20. 20.
    MacNaughton PD, Braude S, Hunter DN, Denison DM, Evans TW (1992) Changes in lung function and pulmonary capillary permeability after cardiopulmonary bypass. Crit Care Med 20: 1289–1294PubMedCrossRefGoogle Scholar
  21. 21.
    Raijmakers PGHM, Groeneveld ABJ, Schneider AJ, et al (1993) Transvascular transport of 67Ga after cardiopulmonary bypass surgery. Chest 104: 1825–1832PubMedCrossRefGoogle Scholar
  22. 22.
    Louagie Y, Gonzales E, Jamart J, Bulliard G, Schoevaerdts JC (1993) Postcardiopulmonary bypass lung edema. A preventable complication? Chest 103: 86–95PubMedCrossRefGoogle Scholar
  23. 23.
    Moore FD, Warner KG, Assousa S, Valeri CR, Khuri SF (1989) The effects of complement activation during cardiopulmonary bypass. Attenuation by hypothermia, heparin and hemodilution. Ann Surg 208: 95–103CrossRefGoogle Scholar
  24. 24.
    Kharazmi A, Andersen LW, Baek L, Valerius NH, Laub M, Rasmussen JP (1989) Endo-toxemia and enhanced generation of oxygen radicals by neutrophils from patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg 98: 381–385PubMedGoogle Scholar
  25. 25.
    Haeffner-Cavaillon N, Roussellier N, Ponzio O, et al (1989) Induction of interleukin-1 production in patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg 98: 1100–1106PubMedGoogle Scholar
  26. 26.
    Kalfin RE, Engelman RM, Rousou JA, et al (1993) Induction of interleukin-8 expression during cardiopulmonary bypass. Circulation 88: 401–406Google Scholar
  27. 27.
    Dauber IM, Parsons PE, Welsh CH, et al (1993) Peripheral bypass-induced pulmonary and coronary vascular injury. Association with increased levels of tumor necrosis factor. Circulation 88: 726–735PubMedGoogle Scholar
  28. 28.
    Rocke DA, Gaffin SL, Wells MT, Koen Y, Brock-Utine JG (1987) Endotoxemia associated with cardiopulmonary bypass. J Thorac Cardiovasc Surg 93: 832–837PubMedGoogle Scholar
  29. 29.
    Paterson IS, Klausner JM, Goldman G, et al (1989) Pulmonary edema after aneurysm surgery is modified by mannitol. Ann Surg 210: 796–801PubMedGoogle Scholar
  30. 30.
    Svensson LG, Hess KR, Coselli JS, Safi HJ, Crawford ES (1991) A prospective study of respiratory failure after high-risk surgery in the thoracoabdominal aorta. J Vasc Surg 14: 271–282PubMedCrossRefGoogle Scholar
  31. 31.
    Brewster DC, Franklin DP, Cambria RP, et al (1991) Intestinal ischemia complicating abdominal aortic surgery. Surgery 109: 447–454PubMedGoogle Scholar
  32. 32.
    Raijmakers PGHM, Groeneveld ABJ, Rauwerda JA, et al (1995) Transient increase in interleukin-8 and pulmonary microvascular permeability following aortic surgery. Am J Respir Crit Care Med (in press)Google Scholar
  33. 33.
    Grootendorst AF, Van Bommel EFH, Van Leengoed LAMG, Nabuurs M, Bouman CSC, Groeneveld ABJ (1994) High volume hemofiltration improves hemodynamics and survival of pigs exposed to gut ischemia and reperfusion. Shock 2: 72–78PubMedCrossRefGoogle Scholar
  34. 34.
    Koike K, Moore EE, Moore FA, Carl VS, Pitman JM, Banerjee A (1992) Phospholipase A2 inhibition decouples lung injury from gut ischemia-reperfusion. Surgery 112: 173–180PubMedGoogle Scholar
  35. 35.
    Harpole DH, Clements FM, Quill T, Wolfe WG, Jones RH, McCann RL (1989) Right and left ventricular performance during and after abdominal aortic aneurysm repair. Ann Surg 209: 356–362PubMedCrossRefGoogle Scholar
  36. 36.
    Mathieson MA, Dunham BM, Huval WV, et al (1983) Ischemia of the limb stimulates thromboxane production and myocardial depression. Surg Gynecol Obstet 157: 500–504PubMedGoogle Scholar
  37. 37.
    Raijmakers PGHM, Groeneveld ABJ, Den Hollander W, Teule GJJ (1992) Transport of 67Ga and 111In across a membrane. Role of plasma binding and concentration gradients. Nucl Med Commun 13: 349–356PubMedCrossRefGoogle Scholar
  38. 38.
    Raijmakers PGHM, Groeneveld ABJ, Rauwerda JA, Teule GJJ, Hack CE, Thijs LG (1995) Aortic surgery increases microvascular 111In-transferrin permeability in legs and lungs. Association with interleukin-8 and neutrophil activation (in press)Google Scholar
  39. 39.
    Kilgore KS, Friedrichs GS, Homeister JW, Lucchesi BR (1994) The complement system in myocardial ischaemia/reperfusion injury. Cardiovasc Res 28: 437–444PubMedCrossRefGoogle Scholar
  40. 40.
    Takayama Y, Iwasaka T, Sugiura T, et al (1991) Increased extravascular lung water in patients with low pulmonary artery occlusion pressure after acute myocardial infarction. Crit Care Med 19: 21–25PubMedCrossRefGoogle Scholar
  41. 41.
    Raijmakers PGHM, Bax J, Groeneveld ABJ, Visser FC, Teule GJJ, Thijs LG (1995) What is the cause of pulmonary oedema after acute myocardial infarction? A case study (in press)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • A. B. J. Groeneveld
  • P. G. H. Raijmakers

There are no affiliations available

Personalised recommendations