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Endogenous Mechanisms Regulating TNF and IL-1 during Sepsis

  • T. van der Poll
  • S. F. Lowry
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1995)

Abstract

In the past decade, it has become increasingly clear that proinflammatory cytokines play a prominent role in the pathophysiology of sepsis. Of these, tumor necrosis factor α (TNF-α) and interleukin 1 (IL-1) seem to be of particular importance. Administration of either TNF-α or IL-1 to experimental animals results in a syndrome that mimics sepsis, and therapy specifically directed against either cytokine protects against lethality in experimental sepsis and endotoxe- mia. In recent years, several endogenous mechanisms meant to protect the host against excessive activity of these highly potent cytokines have been identified. In this chapter, we will briefly discuss current knowledge of the roles of TNF and IL-1 in the pathogenesis of sepsis, and will provide an overview of endogenous mechanisms, that regulate the production and activities of TNF and IL-1.

Keywords

Endogenous Mechanism Tumor Necrosis Factor Level Experimental Endotoxemia Tumor Necrosis Factor Activity Tumor Necrosis Factor Receptor Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • T. van der Poll
  • S. F. Lowry

There are no affiliations available

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