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The Critical Role of the Alveolar Epithelial Barrier in Acute Lung Injury

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1995))

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Abstract

Until recently, the critical importance of the alveolar epithelial barrier in the pathogenesis and recovery from acute lung injury (ALI) has not been well appreciated. However, progress in three areas has created a breakthrough in our understanding of the importance of the alveolar epithelium in ALI. First, in the past ten years the mechanisms that regulate transport of fluid and protein across the normal alveolar epithelial barrier have been identified. Second, there is some new data on the mechanisms responsible for injury to the lung epithelial barriers. Third, because of our new understanding of fluid and protein transport across the normal alveolar epithelial barrier as well as new insights into the process of alveolar epithelial cell repair, it is now possible to study the resolution and recovery from ALI in both the experimental and clinical setting.

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Authors
  1. M. A. Matthay
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  2. G. Nitenberg
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  3. C. Jayr
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1995 Springer-Verlag Berlin Heidelberg

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Matthay, M.A., Nitenberg, G., Jayr, C. (1995). The Critical Role of the Alveolar Epithelial Barrier in Acute Lung Injury. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 1995. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79154-3_3

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  • DOI: https://doi.org/10.1007/978-3-642-79154-3_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58256-4

  • Online ISBN: 978-3-642-79154-3

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