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Inhaled Nitric Oxide: State-of-the-Art

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1995))

Abstract

During the past several years, remarkable progress has been made in understanding the nitric oxide-guanylate cyclase signal transduction system. Nitric oxide (NO) has undergone considerable clinical investigation for acute respiratory distress syndrome (ARDS) patients. This review concentrates on this area of clinical NO research.

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References

  1. Zapol WM, Snider MT, Rie MA, Frikker M, Quinn DA (1985) Pulmonary circulation during adult respiratory distress syndrome. In: Zapol WM, Falke KJ (eds) Acute Respiratory Failure. Marcel Dekker, New York, pp 241–270

    Google Scholar 

  2. Radermacher P, Stanek B, Wust HJ, Tarnow J, Falke KJ (1990) Prostacyclin for the treatment of pulmonary hypertension in the adult respiratory distress syndrome: Effects on pulmonary capillary pressure and ventilation-perfusion distributions. Anesthesiology 72: 238–244

    Article  PubMed  CAS  Google Scholar 

  3. Ignarro LJ, Buga GM, Wood KS, Byrns RE (1987) Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 84: 9265–9269

    Article  PubMed  CAS  Google Scholar 

  4. Palmer RMJ, Ferrige AG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327: 524–526

    Article  PubMed  CAS  Google Scholar 

  5. Ignarro LJ (1991) Signal transduction mechanisms involving nitric oxide. Biochem Pharmacol 41: 485–490

    Article  PubMed  CAS  Google Scholar 

  6. Moncada S, Palmer RMJ, Higgs EA (1991) Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109–142

    PubMed  CAS  Google Scholar 

  7. Palmer RMJ, Ashton DS, Moncada S (1988) Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 333: 664–666

    Article  PubMed  CAS  Google Scholar 

  8. Ignarro LJ (1989) Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein. Circ Res 65: 1–21

    PubMed  CAS  Google Scholar 

  9. Gruetter CA, Gruetter DY, Lyon JE, Kadowitz PJ, Ignarro LJ (1981) Relationship between cyclic guanosine 3´,5´-monophosphate formation and relaxation of coronary artery arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide. J Pharmacol Exp Ther 219: 181–186

    PubMed  CAS  Google Scholar 

  10. Dinh Xuan AT, Higenbottam TW, Clelland C, Pepke-Zaba, Wells FC, Wallwork J (1990) Acetylcholine and adenosine diphosphate cause endothelium-dependent relaxation of isolated human pulmonary arteries. Eur Respir J 3: 633–638

    PubMed  CAS  Google Scholar 

  11. Gerlach H, Rossaint R, Pappert D, Knorr M, Falke KJ (1994) Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx. Lancet 343: 518–519

    Article  PubMed  CAS  Google Scholar 

  12. Pepke-Zaba J, Higenbottam TW, Dinh-Xuan AT, Stone D, Wallwork J (1991) Inhaled nitric oxide as a cause of selective pulmonary vasodilation in pulmonary hypertension. Lancet 338: 1173–1174

    Article  PubMed  CAS  Google Scholar 

  13. Frosteil CG, Blomqvist H, Hedenstierna G, Lundberg J, Zapol WM (1993) Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology 78: 427–435

    Article  Google Scholar 

  14. Högman M, Frostell C, Arnberg H, Hedenstierna G (1993) Inhalation of nitric oxide modulates methacholine-induced bronchoconstriction in the rabbit. Eur Respir J 6: 177–180

    PubMed  Google Scholar 

  15. Cremona G, Dinh Xuan AT, Higenbottam TW (1991) Endothelium-derived relaxing factor and the pulmonary circulation. Lung 169: 185–202

    Article  PubMed  CAS  Google Scholar 

  16. Dinh Xuan AT, Higenbottam TW, Clelland C, Pepke-Zaba J, Cremona G, Wallwork J (1991) Impairment of endothelium-dependent pulmonary artery relaxation in chronic obstructive lung disease. N Engl J Med 324: 1539–1547

    Article  PubMed  CAS  Google Scholar 

  17. Radomski MW, Palmer RMJ, Moncada S (1987) Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet 2: 1057–1058

    Article  PubMed  CAS  Google Scholar 

  18. Adatia I, Thompson J, Landzberg M, Wessel DL (1993) Inhaled nitric oxide in chronic obstructive lung disease. Lancet 341: 307–308

    Article  PubMed  CAS  Google Scholar 

  19. Frostell C, Fratacci M-D, Wain JC, Jones R, Zapol WM (1991) Inhaled nitric oxide: A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation 83: 2038–2047

    PubMed  CAS  Google Scholar 

  20. Fratacci M-D, Frostell CG, Chen T-Y, Wain JC, Robinson DR, Zapol WM (1991) Inhaled nitric oxide: A selective pulmonary vasodilator of heparin-protamine vasoconstriction in sheep. Anesthesiology 75: 990–999

    Article  PubMed  CAS  Google Scholar 

  21. Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, Zapol WM (1993) Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 328: 399–405

    Article  PubMed  CAS  Google Scholar 

  22. Bigatello LM, Hurford WE, Kacmarek RM (1994) Prolonged inhalation of low concentrations of nitric oxide in patients with severe adult respiratory distress syndrome. Anesthesiology 80: 761–770

    Article  PubMed  CAS  Google Scholar 

  23. Puybasset L, Stewart TE, Rouby JJ, et al (1994) Inhaled nitric oxide reverses the increase in pulmonary vascular resistance induced by permissive hypercapnia in patients with acute respiratory distress syndrome. Anesthesiology 80: 1254–1267

    Article  PubMed  CAS  Google Scholar 

  24. Gerlach H, Pappert D, Lewandowski K, Rossaint R, Falke KJ (1993) Long-term inhalation with evaluated low doses of nitric oxide for selective improvement of oxygenation in patients with adult respiratory distress syndrome. Intensive Care Med 19: 443–449

    Article  PubMed  CAS  Google Scholar 

  25. Zapol WM (1993) Minidose inhaled nitric oxide: Less is better. Intensive Care Med 19: 433–434

    Article  PubMed  CAS  Google Scholar 

  26. Gerlach H, Rossaint R, Pappert D, Falke KJ (1993) Time course and dose-response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome. Eur J Clin Invest 23: 449–502

    Article  Google Scholar 

  27. Ricou B, Suter PM (1993) Variable effects of nitric oxide (NO) in ARDS patients. Am Rev Respir Dis 147: A350 (Abst)

    Google Scholar 

  28. Rich GF, Murphy GD, Ross CM, Johns RA (1993) Inhaled nitric oxide: A selective pulmonary vasodilator in cardiac surgical patients. Anesthesiology 78: 1028–1035

    Article  PubMed  CAS  Google Scholar 

  29. Grover R, Murdoch I, Smithies M, Mitchell I, Bihari D (1992) Nitric oxide during hand ventilation in a patient with acute respiratory failure. Lancet 340: 1038–1039

    Article  PubMed  CAS  Google Scholar 

  30. Dupuy PM, Shore SA, Drazen JM, Zapol WM (1992) Bronchodilator action of inhaled nitric oxide in guinea pigs. J Clin Invest 90: 421–428

    Article  PubMed  CAS  Google Scholar 

  31. Rengasamy A, Johns RA (1993) Regulation of nitric oxide synthase by nitric oxide. Mol Pharmacol 44: 124–128

    PubMed  CAS  Google Scholar 

  32. Norman V, Keith CH (1965) Nitrogen oxides in tobacco smoke. Nature 205: 915–916

    Article  CAS  Google Scholar 

  33. Centers for Disease Control (1988) Recommendations for occupational safety and health standard MMWR Morb Mortal Wkly Rep 37 (suppl S-7): 21

    Google Scholar 

  34. Foubert L, Fleming B, Latimer R, et al (1992) Safety guidelines for use of nitric oxide. Lancet 339: 1615–1616

    Article  PubMed  CAS  Google Scholar 

  35. Stavert DM, Lehert BE (1990) Nitric oxide and nitrogen dioxide as inducers of acute pulmonary injury when inhaled at relatively high concentrations for brief periods. Inhal Toxicol 2: 53–67

    Article  CAS  Google Scholar 

  36. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA (1990) Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87: 1620–1624

    Article  PubMed  CAS  Google Scholar 

  37. Stamler JS, Singel DJ, Loscalzo J (1993) Biochemistry of nitric oxide and its redox-acti- vated forms. Science 258: 1898–1902

    Article  Google Scholar 

  38. Beutler E (1977) Methemoglobinemia and sulfhemoglobinemia. In: Williams WJ, Beutler E, Erslev AJ, Rundles RW (eds) Hematology, 2nd edition. McGraw-Hill, New York, pp 491–494

    Google Scholar 

  39. Högman M, Frosteil C, Arnberg H, Hedenstierna G (1993) Bleeding time prolongation and NO inhalation. Lancet 341: 1664–1665

    Article  PubMed  Google Scholar 

  40. Högman M, Frosteil C, Arnberg H, Hedenstierna G (1993) Prolonged bleeding time during nitric oxide inhalation in the rabbit. Acta Physiol Scand 151: 125–129

    Article  Google Scholar 

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Authors
  1. W. M. Zapol
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  2. W. E. Hurford
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1995 Springer-Verlag Berlin Heidelberg

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Zapol, W.M., Hurford, W.E. (1995). Inhaled Nitric Oxide: State-of-the-Art. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 1995. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79154-3_26

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  • DOI: https://doi.org/10.1007/978-3-642-79154-3_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58256-4

  • Online ISBN: 978-3-642-79154-3

  • eBook Packages: Springer Book Archive

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