At the beginning of my research career, during fellowship years at the MGH, I demonstrated for the first time that angiotensin infusion to rats stimulated aldosterone secretion by the rat adrenal gland. While in Melbourne, Australia (Monash University), I initiated work on aspects of reproduction, together with Dr. Kevin Catt developing a sensitive assay for measuring estrogen in the circulation, a protein-binding assay, before the steroid radioimmunoassay era. This assay allowed us to determine the earliest profiles of estradiol in the circulation throughout the menstrual cycle, showing the preovulatory rise of estradiol in 1970. Subsequently, we provided the first demonstration of the blockade of estradiol midcycle peak during treatment with oral contraceptive.

References and Other Sources

  1. Dufau ML (1990) The luteinizing hormone/human chorionic gonadotropin receptor of testis and ovary. Purification and characterization. In: Litwack G (ed) Receptor Purification vol 1. Humana Press, pp 147-171..Google Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Gerhard Bettendorf
    • 1
  1. 1.Abteilung für klinische und experimentelle EndokrinologieUniversitäts-FrauenklinikHamburgBundesrepublik Deutschland

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