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The Role of Nitric Oxide in Physiology and Pathophysiology pp 37–50Cite as

A New Nitric Oxide Scavenger, Imidazolineoxyl N-Oxide Derivative, and Its Effects in Pathophysiology and Microbiology

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 196))

Abstract

The increased appreciation of nitric oxide (NO) as an important molecule in biology and medicine has been accompanied by an unprecedented interest in inhibitors of NO synthesis and NO scavengers. l-Arginine analogues (Fig. 1) have been used widely as competitive inhibitors of NO synthase (NOS), thus inhibiting the function of NO indirectly. Some of these analogues have even been used in human trials, although there are potential problems with in vivo use. l-Arginine analogues may interfere with the urea cycle and protein synthesis, and long-term suppression of both the constitutive (cNOS) and the induced forms (NOS) of the enzyme might result in impairment of the neural and circulatory systems. Although l-arginine analogues can suppress the biological effect of endothelium-derived relaxing factor (EDRF) stimulators, such as acetylcholine, proof that NO is an EDRF awaits the demonstration of chemical entrapment of NO at the site of action with simultaneous disappearance of its vasorelaxing activity. Meanwhile NO gas or dilute NO solutions have been shown to relax vascular tone, and the identity of EDRF with NO appears essentially unambiguous.

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Author information

Authors and Affiliations

  1. Department of Microbiology, Kumamoto University School of Medicine, Honjo 2-2-1, Kumamoto 860, Japan

    H. Maeda, T. Akaike, K. Sato & Y. Noguchi

  2. Department of Urology, Kumamoto University School of Medicine, Honjo 2-2-1, Kumamoto 860, Japan

    M. Yoshida

Authors
  1. H. Maeda
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  2. T. Akaike
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  3. M. Yoshida
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  4. K. Sato
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  5. Y. Noguchi
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Editor information

Editors and Affiliations

  1. Department of Microbiology and Immunology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA, 10107, USA

    Hilary Koprowski (Head of the Center of Neurovirology) (Head of the Center of Neurovirology)

  2. Department of Microbiology, Kumamoto University School of Medicine, Honjo 2-2-1, Kumamoto 860, Japan

    Hiroshi Maeda

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© 1995 Springer-Verlag Berlin Heidelberg

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Maeda, H., Akaike, T., Yoshida, M., Sato, K., Noguchi, Y. (1995). A New Nitric Oxide Scavenger, Imidazolineoxyl N-Oxide Derivative, and Its Effects in Pathophysiology and Microbiology. In: Koprowski, H., Maeda, H. (eds) The Role of Nitric Oxide in Physiology and Pathophysiology. Current Topics in Microbiology and Immunology, vol 196. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79130-7_5

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  • DOI: https://doi.org/10.1007/978-3-642-79130-7_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79132-1

  • Online ISBN: 978-3-642-79130-7

  • eBook Packages: Springer Book Archive

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