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Reference Values for Lung Density and Structure Measured by Quantitative CT

  • W. A. Kalender
  • H. Fichte
  • W. Bautz
  • A. Zwick
  • R. Rienmüller
  • J. Behr
  • J. V. Engelshoven
  • R. Lamers
  • P. Vock

Abstract

Noninvasive in vivo assessment of lung density and structure by quantitative computed tomography (QCT) has a long tradition in the scientific literature. Early efforts were limited, however, as reproducibility was insufficient due to a lack of respiratory control during scanning and appropriate evaluation software was missing (e.g. Goddard et al. 1982; Gilman et al. 1983; Van Dyk and Hill 1983; Mueller et al. 1988; Rienmöller et al. 1988). We have worked on the respective methodology to improve both accuracy and precision and to provide specific evaluation capabilities. Decisive steps were the design of spirometric control and gating for the CT scan process (Kalender et al. 1990a, b; Rienmöller et al, 1990), dedicated evaluation algorithms (Kalender et al. 1991; Rienmöller et al. 1991) and quality control measures as described below. All these steps were incorporated into the PULMO CT option on the SOMATOM PLUS which meanwhile is in broad clinical use. Reference data on lung density and histograms in a healthy population for comparison purposes are still missing, however. It is the purpose of this paper to present first results of a multicenter study established to gather such data. These results still have to be considered preliminary. An extended publication is intended when all participating centers will have acquired the planned numbers of examinations.

Keywords

Interstitial Lung Disease Vital Capacity Quantitative Compute Tomography Pulmonary Emphysema Lung Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • W. A. Kalender
  • H. Fichte
  • W. Bautz
  • A. Zwick
  • R. Rienmüller
  • J. Behr
  • J. V. Engelshoven
  • R. Lamers
  • P. Vock

There are no affiliations available

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