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Therapeutic Use of Quinolones in Oncology

  • Conference paper
Ciprofloxacin i.v.
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Abstract

Infections represent the major cause of mortality in neutropenic cancer patients. As shown in Table 1, infections alone or in combination with bleedings contribute to fatal outcome in patients with acute leukemias in about 70% of treatment failures [1–7].

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References

  1. Hersh EM, Bodey GP, Nies BA, Freireich EJ (1965) Causes of death in acute leukemia. A ten-year study of 414 patients from 1954–1963. JAMA 193:99–103

    Google Scholar 

  2. Schimpff SC, Young VM, Greene WH, Vermeulen GD, Moody MR, Wiernik PH (1972) Origin of infection in acute nonlymphocytic leukemia. Significance of hospital acquisition of potential pathogens. Ann Intern Med 77:707–714

    PubMed  CAS  Google Scholar 

  3. Inagaki J, Rodriguez V, Bodey GP (1974) Causes of death in cancer patients. Cancer 33:568–573

    Article  PubMed  CAS  Google Scholar 

  4. Chang HY, Rodriguez V, Narboni G, Bodey GP, Luna MA, Freireich EJ (1976) Causes of death in adults with acute leukemia. Medicine 55:259–268

    Article  PubMed  CAS  Google Scholar 

  5. Brown AE (1984) Neutropenia, fever, and infection. Am J Med 76:421–428

    Article  PubMed  CAS  Google Scholar 

  6. Estey EH, Keating MJ, McCredie KB, Bodey GP, Freireich EJ (1982) Causes of initial remission induction failure in acute myelogenous leukemia. Blood 50:309–315

    Google Scholar 

  7. O’Hanley P, Easaw J, Rugo H, Easaw S (1989) Infectious disease management of adult leukemic patients undergoing chemotherapy: 1982 to 1986 experience at Stanford University Hospital. Am J Med 87:605–613

    Article  PubMed  Google Scholar 

  8. Fernandes PB (1988) Mode of action, and in vitro and in vivo activities of the fluoroquinolones. J Clin Pharmacol 28:156–168

    PubMed  CAS  Google Scholar 

  9. Stoning RA, Jameson B, McElwain TJ, Wiltshaw E (1977) Oral non-absorbable antibiotics prevent infection in acute non-lymphoblastic leukaemia. Lancet II:837-840

    Google Scholar 

  10. Gurwith MJ, Brunon JL, Lank BA, Harding GKM, Ronald AR (1979) A prospective controlled investigation of prophylactic trimethoprim/sulfamethoxazole in hospitalized granulocytopenic patients. Am J Med 66:248–256

    Article  PubMed  CAS  Google Scholar 

  11. Kauffman CA, Liepman MK, Bergman AG, Mioduszewski J (1983) Trimethoprim/sulfamethoxazole prophylaxis in neutropenic patients. Reduction of infections and effect on bacterial and fungal flora. Am J Med 74:599–607

    CAS  Google Scholar 

  12. Gualtieri RJ, Donowitz GR, Kaiser DL, Less CE, Sande MA (1983) Double-blind randomized study of prophylactic trimethoprim/sulfamethoxazole in granulocytopenic patients with hematologic malignancies. Am J Med 74:934–940

    Article  PubMed  CAS  Google Scholar 

  13. EORTC International Antimicrobial Cooperative Group (1984) Trimethoprim-sulfamethoxazole in the prevention of infection in neutropenic patients. J Infect Dis 150:372–379

    Article  Google Scholar 

  14. Karp JE, Merz WG, Hendricksen C, Laughon B, Redden T, Bamberger BJ, Bartlett SG, Sral R, Burke PJ (1987) Oral norfloxacin for prevention of gram-negative bacterial infections in patients with acute leukemia and granulocytopenia. Ann Intern Med 106:1–7

    PubMed  CAS  Google Scholar 

  15. Winston DJ, Ho WG, Nakao SL, Gale RP, Champlin RE (1986) Norfloxacin versus vancomycin/polymyxin for prevention of infections in granulocytopenic patients. Am J Med 80:884–890

    Article  PubMed  CAS  Google Scholar 

  16. Kern W, Kurrle E (1991) Ofloxacin versus trimethoprim-sulfamethoxazole for prevention of infection in patients with acute leukemia and granulocytopenia. Infection 19:73–80

    Article  PubMed  CAS  Google Scholar 

  17. Dekker AW, Rozenberg-Arska M, Verhoef J (1987) Infection prophylaxis in acute leukemia: a comparison of ciprofloxacin with trimethoprim-sulfamethoxazole and colistin. Ann Intern Med 106:7–12

    PubMed  CAS  Google Scholar 

  18. Donnelly JP, Maschmeyer G, Daenen S on behalf of the EORTC—Gnotobiotic Project Group (1992) Selective oral antimicrobial prophylaxis for the prevention of infection in acute leukemia—ciprofloxacin versus co-trimoxazole plus colistin. Eur J Cancer 28A:873–878

    Article  PubMed  CAS  Google Scholar 

  19. Rozenberg-Arska M, Dekker AW, Verdonck L, Verhoef J (1989) Prevention of bacteremia caused by α-hemolytic streptococci by roxithromycin (RU-28965) in granulocytopenic patients receiving ciprofloxacin. Infection 17:240–243

    Article  PubMed  CAS  Google Scholar 

  20. Warren RE, Wimperis JZ, Baglin TP, Constantine CE, Marcus R (1990) Prevention of infection by ciprofloxacin in neutropenia. J Antimicrob Chemother 26 [Suppl F]:109–123

    PubMed  Google Scholar 

  21. EORTC International Antimicrobial Therapy Cooperative Group (1992) A prospective double-blind study of pefloxacin plus penicillin V or placebo for prophylaxis of bacterial infection in granulocytopenic cancer patients. 32nd Inter-science Conference on Antimicrobial Agents and Chemotherapy, Anaheim, abstract no 1692

    Google Scholar 

  22. Maschmeyer G, Rosenthal E, Wendt F (1989) Bacteriologic surveillance during long-term administration of 4-quinolones. Rev Infect Dis 11 [Suppl 5]:S1238–S1239

    Google Scholar 

  23. Paul Ehrlich Society Study Group (1994) Interventional antimicrobial strategy in febrile neutropenic patients with hematological malignancies—results of a three step randomized multicenter study. Ann Hematol (in press)

    Google Scholar 

  24. Maschmeyer G, Haralambie E, Gaus W, Kern W, Dekker AW, De Vries-Hospers HG, König W, Gutzler F, Daenen S (1988) Ciprofloxacin and norfloxacin for selective decontamination in patients with severe granulocytopenia. Infection 16:98–104

    Article  PubMed  CAS  Google Scholar 

  25. Rolston KVI, Haron E, Cunningham C, Bodey GP (1989) Intravenous ciprofloxacin for infections in cancer patients. Am J Med 87 [Suppl 5A]:261–265

    Article  Google Scholar 

  26. Bayston KF, Want S, Cohen J (1989) A prospective, randomized comparison of ceftazidime and ciprofloxacin as initial empiric therapy in neutropenic patients with fever. Am J Med 87 [Suppl 5A]:269–273

    Article  Google Scholar 

  27. Meunier F, Zinner SH, Gaya H, Calandra T, Viscoli C, Klastersky J, Glauser M, and the European Organization for Research on Treatment of Cancer International Antimicrobial Therapy Cooperative Group (1991) Prospective randomized evaluation of ciprofloxacin versus piperacillin plus amikacin for empiric antibiotic therapy of febrile granulocytopenic cancer patients with lymphomas and solid tumors. Antimicrob Agents Chemother 35:873–878

    PubMed  CAS  Google Scholar 

  28. Johnson PRE, Liu Yin JA, Tooth JA (1992) A randomized trial of high-dose ciprofloxacin versus azlocillin and netilmicin in the empirical therapy of febrile neutropenic patients. J Antimicrob Chemother 30:203–214

    Article  PubMed  CAS  Google Scholar 

  29. Chan CC, Oppenheim BA, Anderson H, Swindell R, Scarffe JH (1989) Randomized trial comparing ciprofloxacin plus netilmicin versus piperacillin plus netilmicin for empiric treatment of fever in neutropenic patients. Antimicrob Agents Chemother 33:87–91

    PubMed  CAS  Google Scholar 

  30. Kelsey SM, Wood ME, Shaw E, Newland AC (1989) Intravenous ciprofloxacin as empirical treatment of febrile neutropenic patients. Am J Med 87 [Suppl 5A]:274–277

    Article  Google Scholar 

  31. Flaherty JP, Weitley D, Edlin B, George D, Arnow P, O’Keefe P, Weinstein RA (1989) Multicenter randomized trial of ciprofloxacin plus azlocillin versus ceftazidime plus amikacin for empiric treatment of febrile neutropenic patients. Am J Med 87 [Suppl 5A]:278–282

    Article  Google Scholar 

  32. Philpott-Howard JN, Barker KF, Wade JJ, Kaczmarski RS, Smedley JC, Mufti GJ (1990) Randomized multicentre study of ciprofloxacin and azlocillin versus gentamicin and azlocillin in the treatment of febrile neutropenic patients. J Antimicrob Chemother 26 [Suppl F]:89–99

    PubMed  Google Scholar 

  33. Kelsey SM, Collins PW, Delord C, Weinhard B, Newland AC (1990) A randomized study of teicoplanin plus ciprofloxacin versus gentamicin plus piperacillin for the empirical treatment of fever in neutropenic patients. Br J Haematol 76 [Suppl 2]:10–13

    Article  PubMed  Google Scholar 

  34. Malik IA, Abbas Z, Karim M (1992) Randomised comparison of oral ofloxacin alone with combination of parenteral antibiotics in neutropenic febrile patients. Lancet 339:1092–1096

    Article  PubMed  CAS  Google Scholar 

  35. Rubenstein EB, Rolston K, Benjamin RS, Loewy J, Escalante C, Manzullo E, Hughes P, Moreland B, Fender A, Kennedy K, Holmes F, Elting L, Bodey GP (1993) Outpatient treatment of febrile episodes in low-risk neutropenic patients with cancer. Cancer 71:3640–3646

    Article  PubMed  CAS  Google Scholar 

  36. Hughes WT, Armstrong D, Bodey GP, Feld R, Mandell GL, Meyers JD, Pizzo PA, Schimpff SC, Shenep JL, Wade JC, Young LS, Yow MD (1990) Guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. J Infect Dis 161:381–396

    Article  PubMed  CAS  Google Scholar 

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© 1994 Springer-Verlag Berlin Heidelberg

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Maschmeyer, G. (1994). Therapeutic Use of Quinolones in Oncology. In: Garrard, C. (eds) Ciprofloxacin i.v.. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79098-0_9

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  • DOI: https://doi.org/10.1007/978-3-642-79098-0_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79100-0

  • Online ISBN: 978-3-642-79098-0

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