The Postantibiotic Effect of Ciprofloxacin
The study of the delayed regrowth of surviving bacteria following cessation of antibiotic administration, the post-antibiotic effect (PAE), and related phenomena such as the integration of the pharmacological and antimicrobial profiles of drugs became known as pharmacodynamics and is increasingly being applied to the design of dose regimens (MacKenzie and Gould 1993). This is necessary as there often seems to be little or no scientific basis for the frequency with which many antibiotics are administered. The PAE should especially influence dosing frequency and is specific to the species of microorganism. The PAE for cefoperazone, for example, in Staphylococcus aureus in vivo is nearly 4 h, but under identical conditions with Escherichia coli it is 0.6 h (Craig and Gudmundsson 1991). Furthermore, many different methods are used to evaluate the PAE. Whichever technique is used, the parameters are not yet standardized, e.g., the properties of the growth medium, including osmolality and pH, the size of the bacterial inoculum, the initial antibiotic concentration, the exposure time to the antibiotic, and the method of antibiotic removal. Therefore, many comparative studies are necessary to evaluate the PAE of the different drugs and their impact on the overall antibiotic activity during the treatment of infectious diseases.
KeywordsMinimal Inhibitory Concentration Minimal Inhibitory Concen Bacterial Inoculum Postantibiotic Effect Antimicrobial Profile
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- Chin N-X, Neu HC (1984) Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria. Antimicrob Agents Chemother 25:3119–3326Google Scholar
- Craig WA, Gudmundsson S (1991) Postantibiotic effect. In: Lorian V (ed) Antibiotics in laboratory medicine, 3rd edn. Williams and Wilkins, BaltimoreGoogle Scholar
- Schedletzky H, Wiedemann B (1993) Stabilität von temären Komplexen aus Gyrase-DNA und 4-Chinolon. Chem J 2(1):27–27Google Scholar