Intravenous Ciprofloxacin for the Treatment of Lower Respiratory Tract Infections: Preliminary Results
Ciprofloxacin has favorable pharmacokinetic characteristics and good antibacterial activity against most respiratory bacterial pathogens. This allows an effective use of ciprofloxacin in bacterial respiratory tract infections . The availability of a drag in both intravenous and oral formulations may allow physicians to prescribe a sequential treatment in which an initial parenteral attack phase is followed by an oral consolidation phase after a few days of clinical improvement. Studies so far performed have demonstrated that in various serious infections oral ciprofloxacin can shorten the course of parenteral antibiotics and thus minimize the period of hospitalization and reduce costs [2–6].
KeywordsChronic Obstructive Pulmonary Disease Chronic Obstructive Pulmonary Disease Patient Lower Respiratory Tract Infection Eradication Rate Klebsiella Oxytoca
Unable to display preview. Download preview PDF.
- 2.Khan FA, Basir R (1989) Sequential intravenous-oral administration of ciprofloxacin vs. ceftazidime in serious bacterial respiratory tract infections. Chest 96:528–537Google Scholar
- 5.Costas J, Chrysantopoulos CJ, Skoutelis AT, Bassaris HP (1993) Shortened hospital stay with sequential intravenous/oral ciprofloxacin. Drugs 45 [Suppl]:75Google Scholar
- 6.Paladino JA, Cumbo TJ, Schentag JJ, Bloom MJ, Serrianne DJ, Burnett GJ (1993) Abbreviating the duration of intravenous antibiotics with oral fluoroquinolones. Drugs 45 [Suppl]:77Google Scholar
- 7.Paladino JA, Van Slooten A (1993) Economic impact of IV and IV-to-PO sequential ciprofloxacin vs. standard IV antibiotics. Drugs 45 [Suppl]:76Google Scholar
- 8.Lode H, Wiley E, Olschewski P et al. (1990) Prospective randomized clinical trials of new quinolones versus beta-lactam antibiotics in lower respiratory tract infections. Scand J Infect Dis 68 [Suppl]:50–55Google Scholar
- 10.Mangiarotti P, Bertoletti R, Grassi G, Piccioni P, Grassi FA, Gialdroni Grassi G (1990) Possibilità di trattamento a breve termine delle infezioni respiratorie. J Chemother 2 [Suppl]:68–73Google Scholar
- 11.Mangiarotti P, Bianchi L, Mazzola G, Meloni F, Ballabio PC, Gialdroni Grassi G (1992) Effect of multiple low dose regimen of ciprofloxacin on steady state theophylline serum concentrations. 8th Mediterranean Congress of Chemotherapy, Athens 24–29 May, abstract no 657Google Scholar