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Immunology and Its Impact on Infections in Surgery pp 39–53Cite as

The Effects of Burn Injury on Cytokine Production and Gene Expression

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Abstract

Severe thermal injury leads to a depression of cell mediated immunity with abnormalities of T-lymphocyte activation and proliferation in response to antigenic or mitogenic stimuli [1–3]. Our laboratory has previously shown that one of the major immunologic abnormalities in this setting is decreased production of interleukin-2 (IL-2) in response to mitogenic stimulation [4]. IL-2 plays a central role in immunoregulation supporting lymphocyte proliferation, promoting helper cell activity and augmenting cytotoxicity.

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References

  1. Wolfe JH, Wu AV, O’Connor NE et al. (1982) Anergy, immunosuppressive serum, and impaired lymphocyte blastogenesis in burn patients. Arch Surg 117:1266–1271

    Article  PubMed  CAS  Google Scholar 

  2. Moss NM, Gough DB, Jordan A, Grbic JT, Rodrick ML, Mannick JA (1988) Temporal correlation of impaired immune response after thermal injury with susceptibility to infection in a murine model. Surgery 104:882–887

    PubMed  CAS  Google Scholar 

  3. Teodorczyk-Injeyan JA, Sparkes BG, Mills GB, Peters WJ, Falk RE (1986) Impairment of T cell activation in burn patients: a possible mechanism of thermal injury-induced immunosuppression. Clin Exp Immunol 65:570–581

    PubMed  CAS  Google Scholar 

  4. Wood JJ, Rodrick ML, O’Mahoney et al. (1984) Inadequate interleukin 2 production: a fundamental immunological deficiency in patients with major burns. Ann Surg 200:311–320

    Article  PubMed  CAS  Google Scholar 

  5. Imboden J, Stobo J (1985) Transmembrane signalling by the T cell antigen receptor: perturbation of the CD3 antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores. J Exp Med 161:446–456

    Article  PubMed  CAS  Google Scholar 

  6. Kuno M, Gardner P (1987) Ion channels activated by inositol 1,4,5-triphosphate in plasma membranes of human T lymphocytes. Nature 326:301–304

    Article  PubMed  CAS  Google Scholar 

  7. Tsudo M, Kozak RW, Goldman CK, Waldmann TA (1987) Contribution of a p75 interleukin-2 binding peptide to a high-affinity interleukin-2 receptor complex. Proc Natl Acad Sci USA 84:4215–4218

    Article  PubMed  CAS  Google Scholar 

  8. Szamel M, Kracht M, Krebs B, Hubner U, Resch K (1990) Activation signals in human lymphocytes: interleukin-2 synthesis and expression of high affinity interleukin 2 receptors require differential signalling for the activation of protein kinase C. Cell Immunol 126:117–128

    Article  PubMed  CAS  Google Scholar 

  9. Fong Y, Moldawer LL, Shires GT, Lowry SF (1990) The biological characteristics of cytokines and their implications in surgical injury. Surg Gynecol Obstet 170:363–378

    PubMed  CAS  Google Scholar 

  10. Takayama TK, Miller C, Szabo G (1990) Elevated tumor necrosis factor alpha production concomitant to elevated prostaglandin E2 production by trauma patients’ monocytes. Arch Surg 125:29–35

    Article  PubMed  CAS  Google Scholar 

  11. Sheehan KC, Ruddle NH, Schreiber RD (1989) Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors. J Immunol 142:3884–3893

    PubMed  CAS  Google Scholar 

  12. Feinberg AP, Vogelstein B (1983) A technique for radiolabelling DNA restriction endonuclease fragments to a high specific activity. Anal Biochem 132:6–13

    Article  PubMed  CAS  Google Scholar 

  13. Teodorczyk-Injeyan JA, McRitchie DI, Peters WJ (1990) Expression and secretion of IL-2 receptor in trauma patients. Ann Surg 212:202–208

    Article  PubMed  CAS  Google Scholar 

  14. Schluter B, Wolfgang K, Koller M et al. (1991) Differential regulation of T and B-lymphocyte activation in severely burned patients. J Trauma 31:239–246

    PubMed  CAS  Google Scholar 

  15. Grbic JT, Mannick JA, Gough DB, Rodrick ML (1991) The role of prostaglandin E2 in immune suppression following injury. Ann Surg 214:253–263

    Article  PubMed  CAS  Google Scholar 

  16. Callery MP, Kamei R, Mangino MJ, Flye MW (1991) Organ interactions in sepsis. Host defense and the hepatic-pulmonary macrophage axis. Arch Surg 126:28–32

    Article  PubMed  CAS  Google Scholar 

  17. Silver GM, Gamelli RD, O’Reilly M, Hebert JC (1990) The effect of interleukin-1 alpha on survival in a murine model of burn wound sepsis. Arch Surg 125: 922–925

    Article  PubMed  CAS  Google Scholar 

  18. Alexander HR, Langstein HN, Doherty GM, Jensen JC, Norton JA (1990) Human recombinant tumor necrosis factor (hrTNF) protection against endotoxin-induced shock and lethality in the rat. Surg Forum 41:103–105

    Google Scholar 

  19. Okusawa S, Gelfand JA, Ikejima T, Connolly RJ, Dinarello CA (1988) Interleukin-1 induces a shock-like effect in rabbits. Synergism with tumor necrosis factor and the effects of cyclooxygenase inhibition. J Clin Invest 81:1162–1172

    Article  PubMed  CAS  Google Scholar 

  20. Border JR (1988) Hypothermia, sepsis multiple systems organ failure and the macrophage. Arch Surg 123:285–286

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. A. F. Horgan
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  2. J. A. Mannick
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  3. D. S. O’Riordan
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  4. M. V. Mendez
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  5. R. C. Holzheimer
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  6. K. Collins
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  7. M. L. Rodrick
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Editor information

Editors and Affiliations

  1. Chirurgische Universitäts- und Poliklinik, Universität Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany

    Rainer Engemann , Rene Holzheimer  & A. Thiede ,  & 

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© 1995 Springer-Verlag Berlin Heidelberg

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Horgan, A.F. et al. (1995). The Effects of Burn Injury on Cytokine Production and Gene Expression. In: Engemann, R., Holzheimer, R., Thiede, A. (eds) Immunology and Its Impact on Infections in Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79079-9_6

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  • DOI: https://doi.org/10.1007/978-3-642-79079-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58145-1

  • Online ISBN: 978-3-642-79079-9

  • eBook Packages: Springer Book Archive

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