Abstract
The purpose of our study was to establish a standardized reproducible animal model of intraperitoneal sepsis, induced by E. coli endotoxinaemia in LEW.1W rats, in order to investigate early immunoserological responses with a view to identifying a mediator-based evaluation system for such sepsis. In the pilot phase of this study we evaluate some mediators like endotoxin, phospholipase A2 and neopterin (biopterin) as possible markers for the outcome, i.e., the prognosis of a peritonitis infection.
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Hunsicker, A. et al. (1995). Endotoxin, Interferon-γ, Biopterin, Serum Phospholipase A2 Activity and β-Endorphin as Differentiation Factors and Their Correlations in the Acute Immune Response During Lethal Gram-Negative Sepsis in LEW Rats. In: Engemann, R., Holzheimer, R., Thiede, A. (eds) Immunology and Its Impact on Infections in Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79079-9_5
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DOI: https://doi.org/10.1007/978-3-642-79079-9_5
Publisher Name: Springer, Berlin, Heidelberg
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