Tolerance to Endotoxin in an Animal Model of Acute Pancreatitis Is Associated with Improved Cellular Immune Function

  • P. J. Curley
  • R. G. Holzheimer
  • M. Nestor
  • I. Saporoschetz
  • J. A. Mannick
  • M. L. Rodrick
Conference paper


Endotoxin is thought to play a central role in the development of irreversible multi-organ failure in patients with septic shock which is the largest cause of mortality in the intensive care setting [1]. Antiserum to the central core of endotoxin has been shown to reduce mortality in septic patients from 39% to 22% [2] lending further credence to the central role of endotoxin in the pathogenesis of multi-organ failure. There is some evidence that endotoxin is involved in the pathogenesis of necrotizing pancreatitis also. Windsor et al. [3] have demonstrated high endotoxin levels in the serum and ascitic fluid of a majority of patients with pancreatic necrosis. Deitch et al. [4] have shown that the absence of bile from the gut of mice leads to increased bacterial translocation and higher levels of bacterial contamination in the caecum thus lending further support to the concept of disimpaction of gallstones for the urgent treatment of gallstone pancreatitis [5].


Acute Pancreatitis Bacterial Translocation Pancreatic Necrosis Acute Cholangitis Gallstone Pancreatitis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • P. J. Curley
  • R. G. Holzheimer
  • M. Nestor
  • I. Saporoschetz
  • J. A. Mannick
  • M. L. Rodrick

There are no affiliations available

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