The Polymorphonuclear Neutrophil: A Newly Recognized Participant in the Immune Response

  • M. L. Rodrick
Conference paper

Abstract

A large body of evidence exists to show that, following major injury or surgery, patients may become immunosuppressed and this may lead to increased susceptibility to life-threatening infections [1–4]. Recent research by numerous investigators has shown that the secretion of the proinflammatory cytokines IL-1, TNF, and IL-6 are markedly elevated in patients following major injury and that this may lead to some of the clinical effects seen in these patients, such as a process of systemic inflammation leading to multiple organ dysfunction (MOD) [5]. Clinical trials of agents which block endotoxin and TNF are currently underway in these patients. Most of this work has focussed on the monocyte/macrophage as the major participant in the proinflammatory cytokine cascade and as a modulator of the immune response of lymphocytes. The goal of this paper is to suggest that the other major phagocytic cell, the polymorphonuclear neutrophil (PMN), has that same potential.

Keywords

Toxicity Hydrogen Peroxide Superoxide Interferon Peri 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

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  • M. L. Rodrick

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