Abstract
A large body of evidence exists to show that, following major injury or surgery, patients may become immunosuppressed and this may lead to increased susceptibility to life-threatening infections [1–4]. Recent research by numerous investigators has shown that the secretion of the proinflammatory cytokines IL-1, TNF, and IL-6 are markedly elevated in patients following major injury and that this may lead to some of the clinical effects seen in these patients, such as a process of systemic inflammation leading to multiple organ dysfunction (MOD) [5]. Clinical trials of agents which block endotoxin and TNF are currently underway in these patients. Most of this work has focussed on the monocyte/macrophage as the major participant in the proinflammatory cytokine cascade and as a modulator of the immune response of lymphocytes. The goal of this paper is to suggest that the other major phagocytic cell, the polymorphonuclear neutrophil (PMN), has that same potential.
Keywords
- Polymorphonuclear Leukocyte
- Polymorphonuclear Neutrophil
- Human Polymorphonuclear Leukocyte
- Human PMNs
- Blastogenic Response
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baker CC (1986) Immune mechanisms and host resistance in the trauma patient. Yale J Biol Med 59:387–393
McRitchie DI, Girott M, Rotstein OD, Teodorczyk-Injeyan JA (1990) Impaired antibody production in blunt trauma: Possible role for T-cell dysfunction. Arch Surg 125:91–96
Wolfe JHN, Saporoschetz I, Young AE, O’Connor NE, Mannick JA (1981) Suppressive serum, suppressor lymphocytes and death from burns. Ann Surg 193:513–520
Moss NM, Gough DB, Jordan AL, Grbic JT, Wood JJ, Rodrick ML, Mannick JA (1988) Temporal correlation of impaired immune response after thermal injury with susceptibility to infection in a murine model. Surgery 104:882–887
Demling R, LaLonde C, Saldinger P, Knox J (1993) Multiple organ dysfunction in the surgical patient: pathophysiology, prevention and treatment. Curr Probl Surg 3:347–412
Kasimir S, Schonfeld W, Alouf JE, Konig W (1990) Effect of Staphylococcus aureus delta-toxin on human granulocyte functions and plateletactivating-factor metabolism. Infect Immun 58:1653–1659
Walker RI, Fowler I (1965) Granulocyte inhibition of human peripheral blood lymphocyte growth in vitro. Exp Cell Res 38:379–385
Bach ML, Bach FH, Widmer M, Oranen H, Wolbers WH (1971) Lymphocyte reactivity in vitro. VII. The effect of polymorphonuclear leukocytes on lymphocyte response. Transplantation 12:283–286
Hsu CCS, Wu MYB, Rivera-Arcilla J (1979) Inhibition of lymphocyte reactivity in vitro by autologous polymorphonuclear cells (PMN). Cell Immunol 48:288–295
El-Hag A, Clark RA (1984) Down-regulation of human natural killer activity against tumors by the neutrophil myeloperoxidase system and hydrogen peroxide. J Immunol 133:3291–3297
Kay HD, Smith DL (1983) Regulation of human lymphocyte-mediated natural killer (NK) cell activity. I. Inhibition in vitro by peripheral blood granulocytes. J Immunol 130:475–483
Petrie HT, Klassen LW, Kay HD (1984) Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes. J Immunol 134:230–234
Zoschke DC, Staite ND (1987) Suppression of human lymphocyte proliferation by activated neutrophils or H2O2: surviving cells have an altered T helper/T suppressor ratio and increased resistance to secondary oxidant exposure. Clin Immunol Immunopathol 42:160–170
Wilson DB (1966) Analysis of some of the variables associated with proliferative response of human lymphoid cells in culture. J Exp Zool 162:161–170
Jones AL (1966) The effect of polymorphonuclear leukocytes on the blastoid transformation of lymphocytes in mixed leukocyte cultures. Transplantation 4: 337–343
Tchorzewski H, Sulowska Z, Denys A (1973) A new lymphocyte transforming factor derived from the lysosomes of polymorphonuclear leukocytes. Experientia 29:481–483
Tchorzewski H, Sulowska Z (1980) The mitogenic and enzymatic activities of polymorphonuclear leukocyte (PMNL) lysosomal proteins examined in vitro. Arch Immunol Ther Exp 28:1–8
Lamster IB, Sonis ST, Mirando DM, Kolodkin AB, Rodrick ML, Wilson RE (1980) Modification of in vitro and in vivo immune function by acute inflammatory cells. Transplantation 30:244–250
Rodrick ML, Lamster I, Sonis S, Wilson RE (1980) Effect of neutrophils on antibody synthesis in mice. J Dent Res 59:460
Rodrick ML, Lamster IB, Sonis ST, Pender SG, Kolodkin AB, Fitzgerald JE, Wilson RE (1982) Effects of supernatants of polymorphonuclear neutrophils recruited by different inflammatory substances on mitogen responses of lymphocytes. Inflammation 6:1–11
Rodrick M, Sonis S, Lamster I, Fitzgerald J, Wilson RE (1981) Immune regulation by soluble factors from PMN. Fed Proc 40:770
Yoshinaga M, Ohkawara S, Nakayama S, Goto F (1983) Characteristics of PMN-derived helper T cell potentiation factor in an inflammatory site. In: Oppenheim J, Cohen S (eds) Interleukins, lymphokines and cytokines. Academic, New York
Rodrick ML, Wood JJ, O’Mahony JB, Davis CF, Grbic JT, Demling RH, Moss NM, Saporoschetz I, Jordan A, D’Eon P, Mannick JA (1986) Mechanisms of immunosuppression associated with severe nonthermal traumatic injuries in man: production of interleukin 1 and 2. J Clin Immunol 6:310–318
Lloyd AR, Oppenheim JJ (1992) The Poly’s lament: the neglected role of the polymorphonuclear neutrophil in the afferent limb of the immune response. Immunol Today 13:169–172
Goto K, Nakamura S, Goto F, Yoshinaga M (1984) Generation of an interleukin-1 like lymphocyte stimulating factor at inflammatory sites: correlation with the infiltration of polymorphonuclear leukocytes. Br J Exp Pathol 65:521–532
Tiku K, Tiku ML, Skoskey JL (1986) Interleukin-1 production by human polymorphonuclear neutrophils. J Immunol 136:3677–3685
Jack RM, Fearon DT (1988) Selective synthesis of mRNA and proteins by human peripheral blood neutrophils. J Immunol 140:4286–4293
Lindemann A, Reidel D, Oster W, Meuer SC, Dietmar B, Mertelsmann RH, Herrmann F (1984) Granulocyte/macrophage colony stimulating factor induces interleukin 1 production by human polymorphonuclear neutrophils. J Immunol 140:837–839
Lord PCW, Wilmoth LMG, Mizel SB, McCall CE (1991) Expression of interleukin-1α and ß genes by human blood polymorphonuclear neutrophils. Am J Pathol 141:397–407
Yamazaki M, Ikenami M, Sugiyama T (1989) Cytotoxin from polymorphonuclear leukocytes and inflammatory ascitic fluids. Br J Cancer 59:353–355
Dubravec DB, Spriggs DR, Mannick JA, Rodrick ML (1990) Circulating human peripheral granulocytes synthesize and secrete tumor necrosis factor alpha. Proc Natl Acad Sei USA 87:6758–6761
Djeu JY, Serbousek D, Blanchard DK (1990) Release of tumor necrosis factor by human polymorphonuclear leukocytes. Blood 76:1405–1409
Klebanoff SJ, Vadas MA, Harlan JM, Sparks LH, Gamble JR, Agosti JM, Waltersdorph AM (1986) Stimulation of neutrophils by tumor necrosis factor. J Immunol 136:4220–4225
Bazzoni F, Cassatella MA, Laudanna C, Rossi F (1991) Phagocytosis of opsonized yeast induces tumor necrosis factor-alpha mRNA accumulation and protein release of its mature protein. J Leukoc Biol 5:223–228
Ichinose Y, Hara N, Ohta M, Aso H, Chikama H, Kawasaki M, Kubota I, Shimizu T, Yagawa K, (1990) Recombinant granulocyte colony-stimulating factor and lipopolysaccharide maintain the phenotype of and superoxide anion generation by neutrophils. Infect Immun 58:1647–1652
Cicco NA, Lindemann A, Content J, Vandenbussche P, Lubbery M, Gauss J, Mertelsmann R, Herrmann F (1990) Inducible production of interleukin-6 by human polymorphonuclear neutrophils: role of granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha. Blood 75:2049–2052
Henschler R, Lindemann A, Brach MA, Mackensen A, Mertelsmann RH, Hermann F (1991) Expression of functional receptors for interleukin-6 by human polymorphonuclear leukocytes. Downregulation by granulocyte-macrophage colony stimulating factor. FEBS Lett 283:47–51
Strieter RM, Kasahara K, Allen R, Showell HJ, Standiford TJ, Kunkel SL (1990) Human neutrophils exhibit disparate chemotactic factor gene expression. Biochem Biophys Res Commun 173:725–730
Meszaros K, Bojta J, Bautista AP, Lang CH, Spitzer JJ (1991) Glucose utilization by Kupffer cells, endothelial cells and granulocytes in endotoxemic rat liver. Am J Physiol 260:G7-G12
Buckle AM, Jayaram Y, Hogg N (1990) Colony-stimulating factors and interferon-gamma differentially affect cell surface molecules shared by monocytes and neutrophils. Clin Exp Immunol 81:339–345
Cobbold S, Hale G, Waldmann H (1987) Non-lineage, LFA-1 family and common leucocyte antigens: new and previously defined clusters. In: McMichael AJ, Beverley PCL, Cobbold S, Crumpton MJ, Gilks W, Gotch FM, Hogg N, Horton M, Ling N, MacLenan ICM, Mason DY, Milstein C, Spiegelhalter D, Waldmann H (eds) Leucocyte typing III. White cell differentiation antigens. Oxford University Press, Oxford, p 788
Griffin JD, Spertini O, Ernst TJ, Belvin MP, Levine HB, Kanakura K, Tedder TF (1990) Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leucocyte adhesion molecule-1 on human neutrophils, monocytes and their precursors. J Immunol 145:576–584
Goldman DW, Goetzel EJ (1984) Heterogeneity of human polymorphonuclear leukocyte receptors for leukotriene B4: identification of a subset of high affinity receptors that transduce the chemotactic response. J Exp Med 159:1027–1041
Buyon JP, Shadick N, Berkman R, Hopkins P, Dalton J, Weissmann G, Winchester R, Abramson SB (1988) Surface expression of Gp 165/95, the complement receptor CR3, as a marker of disease activity in systemic Lupus erythematosus. Clin Immunol Immunopathol 46:141–149
Babcock GF, Alexander JW, Warden GD (1990) Flow cytometric analysis of neutrophil subsets in thermally injured patients developing infections. Clin Immunol Immunopathol 54:117–125
Fitzgerald JE, Sonis ST, Rodrick ML, Wilson RE (1983) Interaction of la antigen-bearing polymorphonuclear leukocytes and murine splenocytes. Inflammation 7:25–33
Lukacs K, Cohen DA, Kaplan AM (1986) HLA-Dr-unrestricted accessory cell function in human neutrophils. Clin Immunol Immunopathol 38:344–349
Sanchez-Madrid F, Nagy J, Robbins E, Simon P, Springer TA (1983) A human leucocyte differentiation antigen family with different alpha subunits and a common beta subunit: the lymphocyte function associated antigen (LFA-1) the C3bi complement receptor (OKM1, Mac-1) and the pl50.95 molecule. J Exp Med 158:1785–1803
Moore FD Jr, Davis C, Rodrick ML, Fearon DT, Mannick JA (1987) Neutrophil activation after thermal injury as assessed by complement receptor upregulation. N Engl J Med 314:948–952
Davis CF, Moore FD Jr, Rodrick ML, Fearon DT, Mannick JA (1987) Neutrophil activation after burn injury: contributions of the classic complement pathway and of endotoxin. Surgery 102:477–484
Anderson DC, Springer TA (1987) Leucocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1 and p150,95 glycoproteins. Annu Rev Med 38:175–194
Fischer A, Seger R, Durandy A, Grospierre B, Virelizier JL, Le Deist F, Griscelli C, Fischer E, Kazatchkine M, Bohler MC et al. (1985) Deficiency of the adhesive protein complex lymphocyte function antigen 1, complement receptor type 3, glycoprotein p150.95 in a girl with recurrent bacterial infections. Effects on phagocytic cells and lymphocyte functions. J Clin Invest 76:2385–2892
Strieter RM, Kasahara K, Allen RM, Standiford TJ, Rolfe MW, Becker FS, Chensue SW, Kunkel SL (1992) Cytokine-induced neutrophil-derived interleukin-8. Am J Pathol 2:397–407
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Rodrick, M.L. (1995). The Polymorphonuclear Neutrophil: A Newly Recognized Participant in the Immune Response. In: Engemann, R., Holzheimer, R., Thiede, A. (eds) Immunology and Its Impact on Infections in Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79079-9_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-79079-9_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-58145-1
Online ISBN: 978-3-642-79079-9
eBook Packages: Springer Book Archive