Is Antihypertensive Therapy Expected to be Different in Postmenopausal Women?

  • Anne Zanchi
  • Hans R. Brunner
Conference paper

Abstract

Coronary heart disease remains the most frequent cause of death among women in the United States and other industrialized countries. Early death after myocardial infarction is higher among women than among men. This may be due to the higher frequency of coexisting diseases or higher age, but delayed care may also be a factor since women undergo fewer invasive procedures for the evaluation of chest pain than men [1, 2].

Keywords

Placebo Estrogen Osteoporosis Stratification Metoprolol 

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References

  1. 1.
    Steingart RM, Packer M, Hamm P et al. (1991) Sex differences in the manage-ment of coronary artery disease. N Engl J Med 325: 226–230PubMedCrossRefGoogle Scholar
  2. 2.
    Wenger NK, Speroff L, Packard B (1993) Cardiovascular health and disease in women. N Engl J Med 329: 247–272PubMedCrossRefGoogle Scholar
  3. 3.
    Kannel WB, Hjortland MC, McNamara PM, Gordon T (1976) Menopause and risk of cardiovascular disease. The Framingham Study. Ann Intern Med 85: 447–452PubMedGoogle Scholar
  4. 4.
    Stampfer MJ, Colditz G A (1991) Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev Med 20: 47–63PubMedCrossRefGoogle Scholar
  5. 5.
    Nabuls AA, Folsom AR, White A, Patsch W, Heiss G, Wu KK, Szklo M (1993) Associatation of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women. N Engl J Med 328: 1069–1075CrossRefGoogle Scholar
  6. 6.
    Vokonas PS, Kannel WB, Cupples LA (1988) Epidemiology and risk of hyper-tension in the elderly: the Framingham Study. J Hypertens 6 [Suppl 1]: S3–S9Google Scholar
  7. 7.
    Mathews KA, Meilahn E, Kuller LH, Kelsey SF, Caggiula AW, Wing RR (1989) Menopause and risk factors for coronary heart disease. N Engl J Med 321: 641–646CrossRefGoogle Scholar
  8. 8.
    Stokes J, Kannel WB, Wolf PA, DD’Agostino RB, Cupples LA (1989) Blood pres¬sure as a risk factor for cardiovascular disease. Hypertension 13 [Suppl I]:I–13–I–18Google Scholar
  9. 9.
    Merkatz RB, Temple R, Sobel S, Feiden K, Kessler DA (1993) Women in clinical trials of new drugs. N Engl J Med 329: 292–296PubMedCrossRefGoogle Scholar
  10. 10.
    Systolic Hypertension in the Elderly Program (SHEP) Cooperative Research Group (1991) Prevention of stroke by antihypertensive treatment in older per-sons with isolated systolic hypertension: final results of SHEP. JAMA 265: 3255–3264CrossRefGoogle Scholar
  11. 11.
    Medical Research Council Working Party (1992) Medical Research Council trial of treatment of hypertension in older adults: principal results. Br Med J 304: 405–412CrossRefGoogle Scholar
  12. 12.
    Riggs BL, Melton JI (1986) Involutional osteoporosis. N Engl J Med 314: 1676–1686PubMedCrossRefGoogle Scholar
  13. 13.
    Sernbo I, Johnell O (1993) Consequences of hip fracture: a prospective study over 1 year. Osteoporosis Int 3: 148–153Google Scholar
  14. 14.
    Consensus Development Conference (1993) Diagnosis, prophylaxis, and treat¬ment of osteoporosis. Am J Med 94: 646–650Google Scholar
  15. 15.
    Dalsky GP, Stocke KS, Ehsani AA, Slatopolsky E, Lee WC, Birge SJ (1988) Weight-bearing exercise training and lumber bone mineral content in postmenopausal women. Ann Intern Med 108: 824–828PubMedGoogle Scholar
  16. 16.
    Middler S, Pak CYC, Murad F, Bartter F (1973) Thiazide diuretics and calcium metabolism. Metabolism 22: 139–146PubMedCrossRefGoogle Scholar
  17. 17.
    Wasnich RJ, Davis J, Ross P, Vogel J (1990) Effect of thiazide on rates of bone mineral loss: a longitudinal study. Br Med J 301: 1303–1304CrossRefGoogle Scholar
  18. 18.
    Transbol I, Christensen MS, Jensen GF, Christiansen C, MacNair P (1982) Thiazide for the postponement of postmenopausal bone loss. Metabolism 31: 383–386PubMedCrossRefGoogle Scholar
  19. 19.
    Ray WA, Griffin MR, Downey W, Melton LJ (1989) Long-term use of thiazide diuretics and risk of hip fracture. Lancet 1: 687–690PubMedCrossRefGoogle Scholar
  20. 20.
    Felson DT, Sloutskis D, Anderson JJ, Anthony JM, Kiel DP (1991) Thiazide diuretics and the risk of hip fracture. Results from the Framingham Study. JAMA 265: 370–373PubMedCrossRefGoogle Scholar
  21. 21.
    Ooms ME, Lips P, van Lingen A, Valkenburg HA (1993) Determinants of bone mineral density and risk factors for osteoporosis in healthy elderly women. J Bone Miner Res 8: 669–675PubMedCrossRefGoogle Scholar
  22. 22.
    Riggs BL, Melton LJ (1992) The prevention and treatment of osteoporosis. N Engl J Med 27: 620–627Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Anne Zanchi
  • Hans R. Brunner

There are no affiliations available

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