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Kinetics of Asbestos-Induced Haemolysis of Human Red Blood Cells

  • Robert Englman
Conference paper
Part of the NATO ASI Series book series (volume 85)

Abstract

Encounters between chrysotile fibres and red blood cells (RBC) lead to the haemolysis of the latter and to the loss of capacity of the former to further damage the cells. Jaurand et al.’s in vitro experiments (1979) yield the evolution of concentrations of healthy RBC and of active chrysotile fibres. When it is assumed that once-reacted RBC are completely deactivated, the rate equations are solvable and show the observed concentrations. Moreover, they show precisely the experimentally observed linear relation beween the inverses of maximal haemolysis and of the ratios of fibre/RBC surtaxes. When the assumption of complete RBC deactivation is rescinded, systematic deviations from the data are found. Observation of the collision fingerprints on the fibres, e.g. by atomic force microscopes, is suggested.

Keywords

Membrane Attack Complex Haemolytic Activity Chrysotile Asbestos Mineral Fibre Chrysotile Fibre 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Robert Englman
    • 1
  1. 1.Soreq N.R.C.YavneIsrael

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