Pleural Lesions Induced by Mineral Dusts, Fibers and Chemicals

  • Anand Prakash Sahu
Conference paper
Part of the NATO ASI Series book series (volume 85)


Pleural fibrosis (PF), Pulmonary Interstitial Fibrosis (PIF), lung cancer and malignant mesothelioma are well documented changes due to asbestosrelated exposure. PF is increasingly more common than PIF in many asbestos-exposed populations. This was found especially true in populations with less intense exposure (Miller and Miller, 1993). India is a developing country, rapidly industrializing and demand for asbestos and its production has, therefore, greatly increased mainly for construction activity such as cement-asbestos industries. The asbestos exposure, mechanism for the development of disease and prevention needs greater attention to safeguard the exposed workers.


Mesothelial Cell Malignant Mesothelioma Asbestos Exposure Pleural Surface Chrysotile Asbestos 
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  1. Bianchi C, Brollo A, Ramani L, Zuch C (1993) Asbestos-related mesothelioma in Monfalcone, Italy. Am J Ind Med 24: 149–160PubMedCrossRefGoogle Scholar
  2. Brody AR (1993) Asbestos-induced lung disease. Environ Health Perspect 100: 525 - 535CrossRefGoogle Scholar
  3. Elmes PC (1990) Fibrous mineral and health. J Geol Soc 137: 525–535CrossRefGoogle Scholar
  4. Hills BA, Butler BD, Barrow RE (1982) Boundary lubrication imparted by pleural surfactants and their identification. J Appl Physiol 52: 463–469Google Scholar
  5. Katada H, Higashiguchi R, Maruyama H, Emi Y, Yokose Y, Takashi S, Mikami R, Konishi Y (1983) Effects of chrysotile asbestos on lung and pleural carcinogenesis of N-bis (2-hydorxypropyl) nitrosamine in rats. Cancer Lett 17: 313–320PubMedCrossRefGoogle Scholar
  6. Maher JF (1992) Lubrication of the peritoneum.Perit Dial Int 12: 346–349Google Scholar
  7. Miller A, Miller JA (1993) Diffuse thickening superimposed on circumscribed pleural thickening related to asbestos exposure. Am J Ind Med 23: 859–871PubMedCrossRefGoogle Scholar
  8. Mossman BT, Marsh JP (1991) Role of active oxygen species in asbestosinduced cytotoxicity cell proliferation and carcinogenesis. In: Harris CC, Lechner JG and Brinkley T eds, Cellular and Molecular aspects of Fiber Carcinogensis pp. 159–168. Cold Spring Harbor Laboratory, Cold Spring Harbor, New YorkGoogle Scholar
  9. Rozga J, Andersson R, Srinivas V, Ahren B, Bengmark S (1990) Influence of phosphatidylcholine on intra-abdominal adhesion formation and peritoneal macrophages. Nephron 54: 134–138PubMedCrossRefGoogle Scholar
  10. Sahu AP, Shanker R (1984) Experimental evidence of possible relationship to choline in pulmonary carcinogensis. In: Symposium on Tumor Promotion and Enhancement of Human and Experimental Respiratory Tract carcinogenesis. William burg, V A, p. 52, U S Environmental Protection AgencyGoogle Scholar
  11. Sahu AP, Saxena AK, Singh KP, Shanker R (1986) Effect of chronic choline administration in rat. Ind J Exp Biol 24: 91–96Google Scholar
  12. Zeisel SH, Wishnok JS, Blusztajn JK (1983) Formation of methylamines from ingested choline and lecithin. J Pharmacol Exp ther 225: 320–324PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Anand Prakash Sahu
    • 1
  1. 1.Preventive Toxicology DivisionIndustrial Toxicology Research CentreLucknowIndia

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