Investigation of the Biodurability and Carcinogenicity of Different Man-Made Mineral Fibres
The carcinogenicity of mineral fibres depends on length and diameter, however, the exact relationships are not yet known. Additionally the biopersistence is an important factor: the carcinogenic effect in the intraperitoneal injection test of fibre types with a short half-time in the lung was weak or not detectable in the case of gypsum, wollastonite, glass ATF 3101, HCl-treated E-glass, and HCl-leached chrysotile (Bellmann et al. 1987; Muhle et al. 1991; Pott et al. 1987, 1988, 1989, 1991, 1994). After elimination from the tissue either by translocation or by disintegration a fibre can no longer act as a carcinogen. The minimum period of persistence could be seen as a kind of threshold value. It will be difficult to detect this “threshold” before knowing the mechanism of fibre carcinogenesis. However, a comparison of data on biopersistence of fibre samples in the lung with carcinogenicity data received after i.p. injection may give another approach for recognizing the “threshold” which is important for the regulation of fibres. In the following, some new results on biopersistence are described and compared with carcinogenicity data.
KeywordsFibre Sample Intratracheal Instillation Carcinogenic Potency Clearance Kinetic Mineral Fibre
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- Bellmann B, Muhle H, Pott F, Konig H, Kloppel H, Spurny K (1987) Persistence of man-made mineral fibres ( MMMF) and asbestos in rat lungs. Ann Occup Hyg 31: 693–709Google Scholar
- Muhle H, Bellmann B, Pott F (1991) Durability of various mineral fibers in rat lungs. In: Brown RC, Hoskins JA, Johnson NF (eds) Mechanisms in fibre carcinogenesis. (NATO ASI series, Vol. 223) Plenum Press New York London, pp 181–187Google Scholar
- Musselman RP, Miiller WC, Easters W, Hadley JG, Kamstrup O, Thevenaz P, Hesterberg TW (1993) Biopersistence of man-made vitreous fibers (MMVF) and crocidolite fibers in rat lungs following short-term exposures. Environ Health Perspect (in press)Google Scholar
- Pott F, Matchek A, Ziem U, Muhle H, Huth F (1988) Animal experiments with chemically treated fibres. Ann Occup Hyg 32: 353–359 (Suppl 1)Google Scholar
- Pott F, Roller M, Ziem U, Reiffer F-J, Bellmann B, Rosenbruch M, Huth F (1989) Carcinogenicity studies on natural and man-made fibres with the intraperitoneal test in rats. In: Bignon J, Peto J, Saracci R (eds) Non-occupational exposure to mineral fibres. IARC Sci Publ No 90, Lyon, pp 173–179Google Scholar
- Pott F, Roller M, Rippe RM, Germann P-G, Bellmann B (1991) Tumours by the intraperitoneal and intrapleural routes and their significance for the classification of mineral fibres. In: Brown RC, Hoskins JA, Johnson NF (eds) Mechanisms in fibre carcinogenesis. (NATO ASI series, Vol. 223). Plenum Press New York London, pp 547–565Google Scholar
- Pott F, Roller M, Kamino K, Bellmann B, Althoff GH, Ulm K (1994) Beurteilung der Kanzerogenitat inhalierbarer Fasern. VDI Berichte 1075 (in press)Google Scholar