Zusammenfassung
Der Nachweis von Neoantigenen, die durch proteolytische Spaltung von Gerinnungsfaktoren bei der Aktivierung des Gerinnungssystem freigelegt werden, erlaubt Einsichten in die molekularen Mechanismen der Gerinnselbildung. Erhöhte Werte von Fibrinmonomeren (FM) im Plasma zeigen, daß Thrombin ohne suffiziente Kontrolle eines Inhibitors Fibrinogen in Fibrin umwandelt. Ein immunologischer Antikörper gegen das N-terminale Ende der ß-Kette und von Scheefers-Borchel et al. [3] gegen das N-terminale Ende der a-Kette nach Abspaltung von Fibrinopeptid B bzw. A wurde eingeführt.
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© 1994 Springer-Verlag Berlin Heidelberg
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Gödde, M., Spannagl, M., Hoffmann, H., Trauner, A., Schramm, W. (1994). Sensitiver intravasaler Nachweis von Fibrinmonomeren im experimentellen Endotoxinschock. In: Scharrer, I., Schramm, W. (eds) 24. Hämophilie-Symposion. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79009-6_61
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DOI: https://doi.org/10.1007/978-3-642-79009-6_61
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