Zusammenfassung
Die Therapie der Komplikationen nach Keratoplastik muß die Bereiche Immunosuppressiva, Virustatika, Antibiotika, Antiglaukomatosa, Gleitmittel und Kontaktlinsen umfassen. Da es sich um eine Langzeitbehandlung handelt, ist die Kenntnis der Nebenwirkungen der Medikamente wichtig. Hierunter fallen besonders die allgemeinen Nebenwirkungen der systemisch gegebenen Immunosuppressiva und die transplantatschädigenden Wirkungen lokaler Medikation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Alldredge OC, Krachmer JH (1981) Corneal types of corneal transplant injection. Their manifestations frequency, preoperative correlates and treatment. Arch Ophthalmol 99: 599–604
Aquavella JV, Ruffin JJ, LoCascio JA (1988) Use of collagen shields as a surgical adjunct. J Cataract Refract Surg 14: 492–495
Beebe WE, Starita RJ, Fellman RL, Lynn JR, Gelen-der H (1990) The use of Molteno implant and anterior chamber tube shunt to encircling band for the treatment of glaucoma in keratoplasty patients. Ophthalmology 97: 1414–1422
Belin MW, Bouchard CS, Frantz S, Chmielinska J (1989) Topical cyclosporine in highrisk corneal transplants. Ophthalmology 96: 1144–1150
Belin MW, Bouchard CS, Pillips TM (1990) Update on topical cyclosporin A. Background, immunology, and pharmacology. Cornea 9: 184–195
Bialasiewicz AA, Jahn GJ (1984) Systemische Acyclovir-Therapie bei rezidivierender durch Herpes simplex Virus bedingter Keratouveitis. Klin Monatsbl Augenheilkd 185: 539–542
Chen YF, Gebhardt BM, Reidy JJ, Kaufman HE (1990) Cyclosporine-containing collagen shields suppress corneal allograft rejection. Am J Ophthalmol 109: 132–137
Cohen EJ, Schwarz LW, Luskind RD, Spaeth GL, Katz LJ, Arentsen JJ, Wilson RP, Moster MD, Laibsen FR (1989) Neodymium: YAG laser transscleral cyclophotocoagulation for glaucoma after penetrating keratoplasty. Ophthalmic Surg 20: 713–716
Fiore PM, Jacobs IH, Goldberg DB (1987) Drug-induced ocular pemphigoid: a spectrum of diseases. Arch Ophthalmol 105: 1660–1663
Foster CS, Lass JH, Moran-Wallace K, Giovanni R (1981) Ocular toxicity of topical antifungal agents. Arch Ophthalmol 99: 1081–1084
Foulks GN (1987) Glaucoma associated with penetrating keratoplasty. Ophthalmology 94: 871–874
Gilvarry AM, Kirkness CM, Steele AD, Rice NS, Fikker LA (1989) The management of post-keratoplasty glaucoma by trabeculectomy. Eye 3: 713–718
Gnad HD, Skorpik C, Radda TM, Paroussis P, Mena-pace R, Kiemen UM (1985) Immunsuppressive Therapie mit Cyclosporin A nach perforierender Keratoplastik. Klin Monatsbl Augenheilkd 187: 398–400
Goichot-Bonnat L, Chemla P, Pouliquen Y (1987) Topical cyclosporin A to prevent the corneal rejection. J Fr Ophtalmol 10: 213–217
Gosselin C, Kreis-Gosselin F, Pouliquen Y (1978) Utilisation thérapeutique des lenutilles souples dans les troubles épithéliaux après greffes de cornée (19 cas). J Fr Ophtalmol 10 (1): 583–588
Groden LR, White W (1990) Porcine collagen corneal shield treatment of persistent epithelial defects following penetrating keratoplasty. CLAO J 16: 95–97
Hill JC (1989) The use of cyclosporine in high-risk keratoplasty. Am J Ophthalmol 107: 506–510
Hirst LW, Werblin T, Novak M et al. (1982) Drug-induced cicatrizing conjunctivitis simulating ocular pemphigoid. Cornea 1: 121–128
Hoffmann F, Wiederholt M (1985) Lokale Behandlung des Hornhauttransplantates beim Menschen mit Cyclosporin A. Klin Monatsbl Augenheilkd 187: 92–96
Huang AJW, Tseng SCG, Kenyon KR (1986) The treatment of ocular surface disease. In: Brightbill FS (ed) Corneal surgery. Mosby Company, St. Louis, MO, pp 593–602
Insler MS, Cooper HD, Kastl PR, Caldwell DR (1985) Penetrating keratoplasty with trabeculectomy. Am J Ophthalmol 100: 593–595
Kahan BD (1989) Cyclosporin. N Engl J Med 321: 1725–1738
Kaufman HE, Rayfield MA (1988) Viral conjunctivity and keratitis. Treatment. In: Kaufman HE, Borron BA, McDonald MB, Waltman S+R (eds) The Cornea. Churchill Livingstone, Edinburgh, pp 313–318
Kirkness CM (1987) Penetrating keratoplasty, glaucoma and silicone drainage tubing. Dev Ophthalmol 14: 161–165
Kirkness CM, Ling Y, Rice NS (1988) The use of silicone drainage tubing to control post-keratoplasty glaucoma. Eye 2: 583–590
Lass JH, Thoft RA, Dohlmann CH (1983) Idoxuridine-induced conjunctival cicatrization. Arch Ophthalmol 101: 747–750
Lemp MA (1979) The effect of extended-wear aphakic hydrophilic contact lenses after penetrating keratoplasty. Am J Ophthalmol 90: 331–335
Litoff D, Krachmer JH (1992) Complications of corneal surgery. Int Ophthalmol Clin 32 (4): 79–96
Mahlberg K, Uusitalo RJ, Gebhardt B, Kaufman HE (1991) Prevention of experimental corneal allograft rejection in rabbits using cyclosporin-collagen shields. Graefes Arch Clin Exp Ophthalmol 229: 69–74
Matsuda M, McRae SM, Inaba M, Manabe R (1989) The effect of hard contact lens wear on the keratoconic corneal endothelium after penetrating keratoplasty. Am J Ophthalmol 107: 246–251
Mayer DJ, Casey TA (1987) Reducing the risk of corneal graft rejection. A comparison of different methods. Cornea 6: 261–268
McDonnell PJ, Robin JB, Schanzlin DJ, Minckler D, Baerveldt G, Smith RE, Heuer D (1988) Molteno implant for control of glaucoma in eyes after penetrating keratoplasty. Ophthalmology 95: 364–369
Miller K, Kieselbach GF, Niederwieser D, Huber Ch, Margreiter R, Göttinger W (1985) Immunsuppression mit Cyclosporin A bei Risikokeratoplastiken. Klin Monatsbl Augenheilkd 187: 394–397
Ostler HB, Okumoto M, Daniels T, Conant M (1980) Drug-induced cicatrization of the conjunctiva. In: O’Connor GR (ed) Immunologic diseases of the mucous membranes. Pathology, diagnosis and treatment. Masson, New York pp 149–158
Patten JT, Gavanegh HD, Allansmith MR (1976) Induced ocular pseudopemphigoid. Am J Ophthalmol 82: 272–276
Pfister RR (1986) Biology of persistent epithelial defects. In: Brightbill FS (ed) Corneal surgery. Mosby Company, St. Lousi, MO, pp 582–593
Pfister RR, Burstein N (1976) The effects of Ophthalmic drugs, vehicles, and preservatives on the corneal epithlium: a scanning electron microscopic study. Invest Ophthalmol Vis Sci 15: 246–259
Polack FM (1975) The corneal host-graft junction. Physiopathology of the scar. Arch Ophthalmol 35: 139–152
Pouliquen Y (1983) Kératoplastie. Bull Soc Belge Ophtalmol 206: 3–15
Pouliquen Y, Patey A, Foster CS et al. (1986) Drug induced cicatricial pemphigoid affecting the conjunctiva; light and electron microscopic features. Ophthalmology 93: 775–783
Reidy JJ, Bryan MG, Kaufman HE (1990) The collagen shield. A new vehicle for delivery of cyclosporin A to the eye. Cornea 9 (3): 196–199
Reinhard T, Sundmacher R (1992) Perforierende Keratoplastik bei endogenem Ekzem. Eine Indikation für systemisches Ciclosporin A — eine retrospektive Studie über 18 Patienten (Perforating keratoplasty in endogenous eczema. An indication for systemic cyclosporin A — a retrospective study of 18 patients). Klin Monatsbl Augenheilkd 201: 159–163
Rossa V, Sundmacher R, Heering P (1990) Systemische Ciclosporin A-Prophylaxe bei Risiko-Keratoplastiken. Klin Monatsbl Augenheilkd 197: 466–469
Seale JP, Compton MR (1986) Side effects of corticosteroid agents. Med J Aust 144: 139
Severin M, Konen W, Kilp H (1983) Therapeutische Weichlinsen nach Keratoplastik, Indikation und Komplikationen. Klin Monatsbi Augenheilkd 182: 41–45
Severin M, Konen W, Neubauer H, Kilp H (1985) Keratoplasty in eczema patients. Proceedings of the VII`’ congress of European Society of Ophthalmology, pp 367–368
Stern GA, Killingsworth DW (1989) Complications of topical antimicrobial agents. Int Ophthalmol Clin 29 (3): 137–142
Sugar A, Bokosky JE, Meyer RF (1985) A randomized trial of topical corticosteroids in epithelial healing after keratoplasty. Cornea 3: 268–271
Sundmacher R (1983) Orale Acylovin-Therapie viro-logisch nachgewiesener intraokularer Herpes simplex Virus Infektion. Klin Monatsbl Augenheilkd 183: 246–250
Sundmacher R, Wolff M (1993) Four years experience with triple procedures in herpes-afflicted eyes. Ger J Ophthalmol 2 (2): 65–69
Sundmacher R, Reinhard T, Heering P (1992) Six years experience with systemic ciclosporin A prophylaxis in high risk perforating keratoplasty patients. Ger J Ophthalmol 1: 432–436
Weber U, Sundmacher R (1988) Die systemische Acyclovir-Therapie herpetischer Sekundärglaukome. Fortschr Ophthalmol 85: 85–87
Wheatcroft S, Singh A, Casey T, McAllister J (1992) Treatment of glaucoma following penetrating keratoplasty with transscleral YAG cyclophotocoagulation. Int Ophthalmol 16: 397–400
Wilson SE, Kaufman HE (1990) Graft failure after penetrating keratoplasty. Sury Ophthalmol 34: 325356
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Severin, M. (1994). Therapie. In: Perforierende Keratoplastik. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79006-5_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-79006-5_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-79007-2
Online ISBN: 978-3-642-79006-5
eBook Packages: Springer Book Archive