Mechanism of Oncogene Activation or Antioncogene Inactivation by External Factors

  • Janos Ladik
  • Wolfgang Förner


As briefly described in Chapter 1, Busch [1] was the first to postulate the existence of cancer-causing genes in normal cells of higher organisms. Though he did not write explicitly about human oncogenes, he assumed that due to carcinogens binding to proteins, these cancer-causing genes become readable by releasing the proteins which block them and so their information content can initiate cancer in a cell. Nowadays we know that — according to all probability — carcinogens exert their effect first of all through binding to DNA. In a paper, one of the present authors (J.L.) together with Suhai and Seel [2], assuming the existence of human oncogenes, reviewed the different possible local and longrange effects through which a chemical carcinogen bound to DNA can interfere with DNA-protein interactions and in this way with the genetic regulation of the oncogenes. Fig. 5.1 shows this so-called reading error theory of Busch modified in that it is assumed that the carcinogen (C) binds to DNA, but not necessarily only at the site of an oncogene.


Conduction Band Valence Band Solitary Wave Chemical Carcinogen Free Charge Carrier 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Janos Ladik
    • 1
  • Wolfgang Förner
    • 1
  1. 1.Institut für Theoretische ChemieUniversität ErlangenErlangenGermany

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