A Model of the Leukocyte Migration Through Solid Tissue

  • Boguslaw A. Skierczynski
  • Shunichi Usami
  • Richard Skalak
Part of the NATO ASI Series book series (volume 84)


Neutrophils are defensive cells that are recruited from the blood into damaged or inflamed tissues by chemotactic agents. Ligand-receptor interactions at the cell surface elicit adhesion, locomotion, granule exocytosis, and the respiratory burst [Baggiolini and Kernen, 1992]. In vitro analysis shows that these responses are controlled at several levels of intracellular signal transduction processes. In this introduction we first review some of the biochemical events associated with these responses.


Actin Filament Actin Polymerization Adhesion Receptor Actin Network Cell Locomotion 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Boguslaw A. Skierczynski
    • 1
  • Shunichi Usami
    • 2
  • Richard Skalak
    • 1
  1. 1.Institute for Biomedical EngineeringUniversity of California, San DiegoLa JollaUSA
  2. 2.Institute of Biomedical ScienceAcademia SinicaTaiwan, ROC

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