Kinetochore Directional Instability in Vertebrate Mitotic Cells

  • Robert V. Skibbens
  • E. D. Salmon
Conference paper
Part of the NATO ASI Series book series (volume 84)


Vertebrate mitotic spindles are formed from oppositely oriented polar microtubule (MT) arrays nucleated from centrosomes. MTs mostly grow and shorten by the addition and loss of tubulin subunits from the MT plus-ends distal from the pole. Chromosomes become attached to the spindle when kinetochores capture and stabilize the dynamically instable MT plus-ends (reviewed in Salmon, 1989).


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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Robert V. Skibbens
    • 1
  • E. D. Salmon
    • 1
  1. 1.Department of BiologyUniversity of North CarolinaChapel HillUSA

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