Kinetochore Directional Instability in Vertebrate Mitotic Cells
Vertebrate mitotic spindles are formed from oppositely oriented polar microtubule (MT) arrays nucleated from centrosomes. MTs mostly grow and shorten by the addition and loss of tubulin subunits from the MT plus-ends distal from the pole. Chromosomes become attached to the spindle when kinetochores capture and stabilize the dynamically instable MT plus-ends (reviewed in Salmon, 1989).
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- Cassimeris, L., C.L. Rieder and E.D. Salmon. 1993. Microtubule assembly and kinetochore directional instability in vertebrate monopolar spindles: implications for the mechanism of chromosome congression..J. Cell Science, submitted.Google Scholar
- Gorbsky, G. 1992. Chromosome motion in mitosis. BioEssays 14: 73–80.Google Scholar
- Leslie, R.J. 1992. Chromosomes attain a metaphase position on half-spindles in the absence of an opposing spindle pole. J. Cell Science 103: 125–130.Google Scholar
- Mitchison, T.J. 1989. Chromosomes alignment at mitotic metaphase: balanced forces or smart kinetochores? Cell Movement. Volume 2: Kinesen, Dynein, and Micerotubule dynamics. 421–430.Google Scholar
- Salmon, E.D. 1989. Microtubule dynamics and chromosome movement. In Mitosis: Molecules and Mechanisms, eds. Hyam and Brinkley. Academic Press Limited, 119–181.Google Scholar
- Sawin, K.E., T.J. Mitchison, and L.G. Wordeman. 1992. Evidence for kinesin-related proteins in the mitotic apparatus using peptide antibodies. J. Cell Science 101: 303–313.Google Scholar