The Mitochondrial Pyruvate Carrier: The Mechanism of Substrate Binding
Pyruvate, a compound connecting the metabolic pathways in catabolism and anabolism of sugars, fatty acids and amino acids, in most cases must enter mitochondria where its further metabolism takes place. Pyruvate transport, catalysed by a specific carrier (Papa et al., 1971), occurs either due to a ΔpH dependent process (Papa & Paradies, 1974) or in an exchange with other 2-oxo- or halogenated monocarboxylates (Paradies & Papa, 1977), which can have great significance in the removal of ketone bodies in vivo.
KeywordsArginine Choline Histidine Phosphatidyl Choline 1_14C
4, 4’-diisothiocyano-2, 2’-stilbene disulfonate
p-hydroxymercuribenzoate (p-chloromercuribenzoic acid)
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