The Mitochondrial Pyruvate Carrier: The Mechanism of Substrate Binding

  • Katarzyna A. Nałęcz
Conference paper
Part of the NATO ASI Series book series (volume 83)

Abstract

Pyruvate, a compound connecting the metabolic pathways in catabolism and anabolism of sugars, fatty acids and amino acids, in most cases must enter mitochondria where its further metabolism takes place. Pyruvate transport, catalysed by a specific carrier (Papa et al., 1971), occurs either due to a ΔpH dependent process (Papa & Paradies, 1974) or in an exchange with other 2-oxo- or halogenated monocarboxylates (Paradies & Papa, 1977), which can have great significance in the removal of ketone bodies in vivo.

Keywords

Arginine Choline Histidine Phosphatidyl Choline 1_14C 

Abbreviations

DEPC

diethylpyrocarbonate

DIDS

4, 4’-diisothiocyano-2, 2’-stilbene disulfonate

DTE

dithioerythritol

HTP

hydroxylapatite

NEM

N-ethylmaleimide

pCMB

p-hydroxymercuribenzoate (p-chloromercuribenzoic acid)

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Katarzyna A. Nałęcz
    • 1
  1. 1.Nencki Institute of Experimental BiologyWarsawPoland

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