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The Mitochondrial Pyruvate Carrier: The Mechanism of Substrate Binding

  • Conference paper
Molecular Biology of Mitochondrial Transport Systems

Part of the book series: NATO ASI Series ((ASIH,volume 83))

Abstract

Pyruvate, a compound connecting the metabolic pathways in catabolism and anabolism of sugars, fatty acids and amino acids, in most cases must enter mitochondria where its further metabolism takes place. Pyruvate transport, catalysed by a specific carrier (Papa et al., 1971), occurs either due to a ΔpH dependent process (Papa & Paradies, 1974) or in an exchange with other 2-oxo- or halogenated monocarboxylates (Paradies & Papa, 1977), which can have great significance in the removal of ketone bodies in vivo.

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Abbreviations

DEPC:

diethylpyrocarbonate

DIDS:

4, 4’-diisothiocyano-2, 2’-stilbene disulfonate

DTE:

dithioerythritol

HTP:

hydroxylapatite

NEM:

N-ethylmaleimide

pCMB:

p-hydroxymercuribenzoate (p-chloromercuribenzoic acid)

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Authors and Affiliations

  1. Nencki Institute of Experimental Biology, Pasteur str.3, 02-093, Warsaw, Poland

    Katarzyna A. Nałęcz

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  1. Katarzyna A. Nałęcz
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Editors and Affiliations

  1. Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, 3181 S. W. Sam Jackson Park Rd., Portland, OR, 97201, USA

    Michael Forte

  2. Department of Zoology, University of Maryland, College Park, MD, 20742, USA

    Marco Colombini

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© 1994 Springer-Verlag Berlin Heidelberg

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Nałęcz, K.A. (1994). The Mitochondrial Pyruvate Carrier: The Mechanism of Substrate Binding. In: Forte, M., Colombini, M. (eds) Molecular Biology of Mitochondrial Transport Systems. NATO ASI Series, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78936-6_6

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  • DOI: https://doi.org/10.1007/978-3-642-78936-6_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78938-0

  • Online ISBN: 978-3-642-78936-6

  • eBook Packages: Springer Book Archive

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