Structure and Function of the VDAC Ion Channel
Mitochondria function within the cytoplasm of eukaryotic cells separated from the cytoplasm by a membranous barrier, the mitochondrial outer membrane. Permeability pathways in this membrane, such as the VDAC channels, can be viewed both as a means by which metabolites may travel from one compartment to the other and as a means of controlling the flux of such metabolites. Both of these functions depend on the properties of the permeating pathways, such as the VDAC channels. By examining in detail the properties of VDAC one should obtain insights into its role in mitochondrial function.
KeywordsPermeability Hydroxide Respiration Polypeptide Cytosol
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- Colombini M (1986) Voltage gating in VDAC: toward a molecular mechanism. In “Ion Channel Reconstitution” (C. Miller, ed.), pp. 533–552, Plenum, New York.Google Scholar
- Teorell T (1957) Transport processes and electrical phenomena in ionic membranes. Prog Biophys Chem 3: 305–369Google Scholar
- Zambrowicz EB, Colombini M (1993) Zero-current potentials in a large membrane channel: a simple theory accounts for complex behavior. Biophys J (in press)Google Scholar
- Zalman LS, Nikaido, H, Kagawa, Y (1980) Mitochondrial outer membrane contains a protein producing nonspecific diffusion channels. J Biol Chem 255: 1771–1774Google Scholar