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Insights Into the Structure of the Mitochondrial Channel, VDAC, Provided by Electron Microscopy

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Molecular Biology of Mitochondrial Transport Systems

Part of the book series: NATO ASI Series ((ASIH,volume 83))

Abstract

It has been ten years since publication of the finding that outer membranes isolated from mitochondria of the fungus Neurospora crassa may bear periodic arrays of stain-accumulating subunits, which were later identified as the voltage-dependent anion-selective channel, VDAC (Mannella, 1982). In the ensuing years, considerable progress has been made both in controlling the crystallization process and in characterizing the structure of the arrays. The aim of the present report is to summarize information about the structure of the VDAC channel that has been obtained from high-resolution electron microscopy and image analysis of these two-dimensional (2D) crystals.

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Authors and Affiliations

  1. Wadsworth Center for Laboratories and Research, New York State Department of Health, and Department of Biomedical Sciences School of Public Health, State University of New York at Albany, Empire State Plaza, Box 509, Albany, NY, 12201-0509, USA

    Carmen A. Mannella

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  1. Carmen A. Mannella
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Editor information

Editors and Affiliations

  1. Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, 3181 S. W. Sam Jackson Park Rd., Portland, OR, 97201, USA

    Michael Forte

  2. Department of Zoology, University of Maryland, College Park, MD, 20742, USA

    Marco Colombini

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© 1994 Springer-Verlag Berlin Heidelberg

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Mannella, C.A. (1994). Insights Into the Structure of the Mitochondrial Channel, VDAC, Provided by Electron Microscopy. In: Forte, M., Colombini, M. (eds) Molecular Biology of Mitochondrial Transport Systems. NATO ASI Series, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78936-6_18

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  • DOI: https://doi.org/10.1007/978-3-642-78936-6_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78938-0

  • Online ISBN: 978-3-642-78936-6

  • eBook Packages: Springer Book Archive

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