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The Mitochondrial Outer Membrane Contains at Least Two Distinct Channels

  • M. Thieffry
  • F. Fèvre
  • M. Pelleschi
  • J. P. Henry
Part of the NATO ASI Series book series (volume 83)

Abstract

The presence in the mitochondrial outer membrane of a cationic channel blocked by a 13 residue addressing peptide had been shown by the technique of “tip-dip”. This channel was studied in planar bilayers and compared to the anionic porin, the voltage-dependent anion channel, observed in the same conditions. The two activities were clearly different. The peptide sensitive channel, present in both wild type and porin-deficient mutant yeast, is not a rescue channel, but an alternate independent permeability pathway. The channel interacted more strongly with a longer extension of the addressing peptide containing 22 residues, suggesting a physiological interaction of this type of molecule with the cationic channel.

Keywords

Adrenal Cortex Cationic Channel Cationic Selectivity Planar Bilayer Basic Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • M. Thieffry
    • 1
  • F. Fèvre
    • 1
  • M. Pelleschi
    • 2
  • J. P. Henry
    • 2
  1. 1.Laboratoire de Neurobiologie Cellulaire et MoléculaireCNRSGif-sur-Yvette CedexFrance
  2. 2.Service de Neurobiologie Physico-Chimique, URA-CNRS 1112Institut de Biologie Physico-ChimiqueParisFrance

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