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Medikamentöse Therapie, Inhalationstherapie

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Grundzüge der Beatmung

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Zusammenfassung

Zur erfolgreichen Respiratortherapie gehört auch der gezielte Einsatz von Pharmaka: einerseits um bei bestimmten Indikationen eine optimale Adapta- tion an das gewählte Beatmungsverfahren zu ermöglichen, andererseits um eine Verbesserung gewisser pulmonaler Störfaktoren zu erreichen. Daher sind prinzipiell zwei ganz verschiedene medikamentöse Zielrichtungen zu bespre- chen, nämlich die therapeutischen Verfahren zur Sedierung/Analgesierung und Relaxation sowie jene medikamentösen Maßnahmen, die bronchodilatatorisch und mukokinetisch wirksam sind.

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Literatur

  1. Adams HA, Biscoping J, Russ W, Bachmann B, Ratthey K, Hempelmann G (1988) Untersuchungen zur sedativ-analgetischen Medikation beatmungspflichtiger Intensivpatienten. Anaesthesist 37:268

    PubMed  CAS  Google Scholar 

  2. Beller JP, Potteches T, Lugnier A, Mangin P, Otteni JC (1988) Prolonged sedation with Propofol in ICU patients: recovery and blood concentration changes during periodic interruptions in infusion. Br J Anaesth 61:583

    Article  PubMed  CAS  Google Scholar 

  3. Bergstrand H (1985) Xanthines as phosphodiesterase inhibitors. In: Andersson KE, Persson CGA (eds) Anti-asthmatic xanthines and adenosine. Excerpta Medica, Amsterdam, p 61

    Google Scholar 

  4. Bonshey HA, Holtzmann MJ, Sheller JR, Nadel JA (1980) State of the art. Bronchial hyperreactivity. Am Rev Respir Dis 121:384

    Google Scholar 

  5. Britton MG, Collins JV, Brown D, Faithhurst NPA, Lambert RG (1976) High-dose corticosteroids in severe acute asthma. Br Med J 2:73

    Article  PubMed  CAS  Google Scholar 

  6. Bryant S, Edwards RHT, Faulkner JA, Hughes RL, Roussos C (1986) Respiratory muscle failure: fatigue or weakness? The role of theophylline. Chest 89:116

    Article  PubMed  CAS  Google Scholar 

  7. Cockshott ID (1985) Propofol („Diprivan“) pharmacokinetics and metabolism - an overview. In: Healy TEJ, Hoffbrand BI, Kay B, Oakes AEM, Mc Ainsh J, Glen JB, Stark RD (eds) Postgraduate Medical Journal, vol 61, Suppl 3: Propofol („Diprivan“) a new intravenous anaesthetic, p 45

    Google Scholar 

  8. Diamond L, Altiere RJ, Thompson DC (1988) The airway nonadrenergic noncholinergic inhibitory nervous system. Chest 93:1283

    Article  PubMed  CAS  Google Scholar 

  9. Dick W, Knoche E, Grundlach G, Klein I (1983) Klinisch experimentelle Untersuchungen zur postoperativen Infusionsanalgesie. Anaesthesist 32: 272

    PubMed  CAS  Google Scholar 

  10. Dirnagel K (1971) Technisch-physikalische Grundlagen der Inhalationstherapie mit Aerosolen in ihrer Bedeutung für die Auswahl von Aerosolgeräten. Dtsch Med Wochenschr 22:245

    Google Scholar 

  11. Doenicke A (1989) Vortrag Festsymposium H. Benzer

    Google Scholar 

  12. Fanta CH, Rossing TH, Mc Fadden Jr ER (1982) Emergency room treatment of asthma. Relationship among therapeutic combinations, severity of obstruction, and time course of response. Am J Med 72:416

    Article  PubMed  CAS  Google Scholar 

  13. Grounds RM, Lalor JM, Lumley J, Royston D, Morgan M (1987) Propofol infusion for sedation in the intensive care unit: preliminary report. Br Med J 294:397

    Article  CAS  Google Scholar 

  14. Guyatt GH, Townsend M, Kazim F, Newhouse MT (1987) A controlled trial of Ambroxol in chronic bronchitis. Chest 92:618

    Article  PubMed  CAS  Google Scholar 

  15. Hiller FC, Mazumder MK, Wilson JD, Renninger RG, Bone RC (1981) Physical properties of therapeutic aerosols. Chest 80:901

    Article  PubMed  CAS  Google Scholar 

  16. Hoffmann P (1987) Kombination von Benzodiazepinen und Opioiden in der Intensivmedizin. Anaesthesist 36 (Suppl): 201

    Google Scholar 

  17. Holgate ST, Cushley MJ, Church MK, Hughes P, Mann JS (1985) Adenosine: a potential mediator of bronchial asthma and its antagonism by methylxanthines. In: Andersson KE, Persson CGA (eds) Antiasthmatic xanthines and adenosine. Excerpta Medica, Amsterdam, p 84

    Google Scholar 

  18. Horrobin DF, Manku MS, Franks DJ, Hamet P (1977) Methylxanthines phosphodiesterase inhibitors behave as prostaglandin antagonists in a perfused rat mesenteric artery preparation. Prostaglandins 13:33

    Article  PubMed  CAS  Google Scholar 

  19. Hunter JM, Parker CJR, Bell CF, Jones RS, Utting JE (1985) The use of different doses of vecuronium in patients with liver dysfunction. Br J Anaesth 57:758

    Article  PubMed  CAS  Google Scholar 

  20. Kaik G (1980) Bronchospasmolytika und ihre klinische Pharmakologie. Urban & Schwarzenberg, München

    Google Scholar 

  21. Klotz U (1988) Zur Toxikologie der in der Analgosedierung eingesetzten Pharmaka. In: Schulteam Esch J, Benzer H (Hrsg) Analgosedierung der Intensivpatienten. Anaesthe- siologie und Intensivmedizin, Bd 200. Springer, Berlin Heidelberg New York London Paris Tokyo, p 1

    Google Scholar 

  22. Kolbeck RC, Speir Jr WA, Carrier GO, Bransome Jr ED (1979) Apparent irrelevance of cyclic nucleotides to the relaxation of tracheal smooth muscle induced by theophylline. Lung 156:173

    Article  PubMed  CAS  Google Scholar 

  23. Kubota E, Hamasaki Y, Sata T, Saga T, Said SI (1988) Autonomic innervation of pulmonary artery: evidence for a nonadrenergic noncholinergic inhibitory system. Exp Lung Res 14:349

    Article  PubMed  CAS  Google Scholar 

  24. Langrehr D, Miranda DR, Stoutenbeek CRP, Zandstra DF, van Saene HKF (1986) Ketamin-Benzodiazepin-Kombination zur Sedierung von Intensivpatienten. In: Schulteam Esch J (Hrsg) Langzeitsedierung des Intensivpatienten. Zuckschwerdt, München Bern Wien, p 46

    Google Scholar 

  25. Lauven PM, Stoeckel H, Schüttler J (1982) Zur Pharmakokinetik der intravenösen Narkotika. In: Lawin P, Götz E, Huth H (Hrsg) Intravenöse Narkose und Langzeitsedierung. Thieme, Stuttgart New York, p 10

    Google Scholar 

  26. Lehmann KA (1988) Analgosedierung mit Opioiden. In: Schulteam Esch J, Benzer H (Hrsg) Analgosedierung der Intensivpatienten. Anaesthesiologie und Intensivmedizin, Bd 200. Springer, Berlin Heidelberg New York London Paris Tokyo, p 14

    Google Scholar 

  27. Lippmann M, Esch JI (1988) Effect of lung airway branching pattern and gas composition on particle deposition. I. Background and literature review. Exp Lung Res 14:311

    Article  PubMed  CAS  Google Scholar 

  28. Lynam DP, Cronelly R, Castagnoli KP, Canfell C, Caldwell J, Arden J, Miller RD (1988) The pharmacodynamics and pharmacokinetics of vecuronium in patients anaesthetized with isoflurane with normal renal function or with renal failure. Anesthesiology 69:227

    Article  PubMed  CAS  Google Scholar 

  29. Magnussen H, Macha HN (1983) Pharmakotherapie des schweren Asthma-Anfalles. Dtsch Med Wochenschr 108: 1291

    Article  PubMed  CAS  Google Scholar 

  30. Mc Fadden Jr ER, Kiser R, de Groot WJ, Holmes B, Kiker R, Viser G (1976) A controlled study of the effects of single doses of hydrocortisone on the resolution of acute attacks of asthma. Am J Med 60:52

    Article  Google Scholar 

  31. Newman LH, Mc Donald JC, Wallace PGM, Ledingham IMcA (1987) Propofol infusion for sedation in intensive care. Anaesthesia 42:929

    Article  PubMed  CAS  Google Scholar 

  32. Newman SP, Clarke SW (1983) Therapeutic aerosols 1 - physical and practical considerations. Thorax 38:881

    Article  PubMed  CAS  Google Scholar 

  33. Oldenhof H, de Jong M, Steenhoek A, Janknegt R (1988) Clinical pharmacokinetics of midazolam in intensive care patients, a wide interpatient variability? Clin Pharmacol Ther 43:263

    Article  PubMed  CAS  Google Scholar 

  34. Owen RT, Tyrer P (1983) Benzodiazepine dependence - a review of the evidence. Drugs 25:385

    Article  PubMed  CAS  Google Scholar 

  35. Park GR, Manara AR, Mendel L, Bateman PE (1987) Ketamine infusion. Anaesthesia 42:980

    Article  PubMed  CAS  Google Scholar 

  36. Parker CJR, Jones JE, Hunter JM (1988) Disposition of infusions of atracurium and its metabolite, laudanosme, in patients in renal and respiratory failure in an ITU. Br J Anaesth 61:531

    Article  PubMed  CAS  Google Scholar 

  37. Paterson JW, Woolcock AJ, Shenfield GM (1979) Bronchodilator drugs. Am Rev Respir Dis 120: 1149

    PubMed  CAS  Google Scholar 

  38. Patrick MR, Blair IJ, Feneck RO, Sebel PS (1985) A comparison of the haemodynamic effects of propofol („Diprivan“) and thiopentone in patients with coronary artery disease. In: Healy TEJ, Hoffbrand BI, Kay B, Oakes AEM, Mc Ainsh J, Glen JB, Stark RD (eds) Postgraduate Medical Journal, vol 61, Suppl 3: Propofol („Diprivan“) a new intravenous anaesthetic, p 23

    Google Scholar 

  39. Rawal N, Tandon B (1985) Epidural and intrathecal morphine in intensive care units. Intensive Care Med 11:129

    Article  PubMed  CAS  Google Scholar 

  40. Rochat T, Vonwil A, Bachofen H (1983) Die Inhalation von ß-Stimulatoren. Wirkungsvergleich zwischen sieben verschiedenen Inhalationsgeräten. Schweiz Med Wochenschr 113:314

    PubMed  CAS  Google Scholar 

  41. Sinclair ME, Sear JW, Summerfield RJ, Fisher A (1988) Alfentanil infusions on the intensive therapy unit. Intensive Care Med 14:55

    Article  PubMed  CAS  Google Scholar 

  42. Swift DL (1980) Generation and respiratory deposition of therapeutic aerosols. Am Rev Respir Dis 122:71

    PubMed  CAS  Google Scholar 

  43. Wadon AJ, Dogra S, Anand S (1986) Atracurium infusion in the intensive care unit. Br J Anaesth 58:64S

    PubMed  Google Scholar 

  44. Wanner A, Rao A (1980) Clinical indications for and effects of bland, mucolytic and antimicrobial aerosols. Am Rev Respir Dis 122:79

    PubMed  CAS  Google Scholar 

  45. Ward MJ, Fentem PH, Smith WHR, Davies D (1981) Ipratropium bromide in acute asthma. Br Med J 282:598

    Article  CAS  Google Scholar 

  46. Watt I, Ledingham IMcA (1984) Mortality amongst multiple trauma patients admitted to an intensive therapy unit. Anaesthesia 39:973

    Article  PubMed  CAS  Google Scholar 

  47. Yate PM, Flynn PJ, Arnold RW, Weatherby BC, Simmons RJ, Dopson T (1987) Clinical experience and plasma laudanosine concentrations during the infusion of atracurium in the intensive therapy unit. Br J Anaesth 59:211

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. S. Fitzal
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Editors and Affiliations

  1. Universitätsklinik für Anästhesiologie, Klinikum der Universität Ulm, Prittwitzstraße 43, D-89075, Ulm (Donau), Germany

    J. Kilian

  2. Universitätsklinik für Anaesthesie und allgemeine Intensivmedizin, Anichstraße 35, A-6020, Innsbruck, Austria

    H. Benzer (Vorstand) (Vorstand)

  3. Universitätsklinik für Anästhesiologie, Klinikum der Universität Ulm, Steinhövelstraße 9, D-89075, Ulm (Donau), Germany

    F. W. Ahnefeld

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© 1994 Springer-Verlag Berlin Heidelberg

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Fitzal, S. (1994). Medikamentöse Therapie, Inhalationstherapie. In: Kilian, J., Benzer, H., Ahnefeld, F.W. (eds) Grundzüge der Beatmung. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78933-5_12

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  • DOI: https://doi.org/10.1007/978-3-642-78933-5_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-57904-5

  • Online ISBN: 978-3-642-78933-5

  • eBook Packages: Springer Book Archive

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