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The Pathogenic Role of Human Immunodeficiency Virus Accessory Genes in Transgenic Mice

  • B. T. Tinkle
  • H. Ueda
  • G. Jay
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 193)

Abstract

Human immunodeficiency virus (HIV) type 1, the causative agent of acquired immune deficiency syndrome (AIDS), was isolated almost a decade ago (Barré-Sinoussi et al. 1983; Popovic et al. 1984). HIV infection is mediated by the binding of the virus to the CD4 cell surface molecule and subsequent viral penetration (Dalgleish et al. 1984; Klatzmann et al. 1984; McDougal et al. 1986). Cells known to bear CD4 include the T-helper/inducer cells (Terhorst et al. 1980), immature thymocytes (Schnittman et al. 1990), Epstein-Barr virus (EBV)+ B lymphoblastoid cells (Dalgleish et al. 1984; Salahuddin et al. 1987; Monroe et al. 1988), monocytes/macrophages (Wood et al. 1983; Dalgleish et al. 1984), follicular dendritic cells (Wood et al. 1983; Macatonia et al. 1990), Langerhans cells (Wood et al. 1983; Tschachler et al. 1987), astrocytes (Funke et al. 1987), neurons (Funke et al. 1987), and glomerular mesangial cells (KARLSSON-PARRA et al. 1989).

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Acquire Immune Deficiency Syndrome Acquire Immune Deficiency Syndrome Patient Human Immunodeficiency Virus Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ablashi DV, Sturzenegger S, Hunter EA, Palestine AG, Fujikawa LS, Kim MK, Nussenblatt RB, Markham PD, Salahuddin SZ (1987) Presence of HTLV-III in tears and cells from the eyes of AIDS patients. J Exp Pathol 3: 693–703PubMedGoogle Scholar
  2. Abramczuk JW, Pezen DS, Leonard JM. Monell-Torrens E, Belcher JH, Martin MA, Notkins AL (1992) Transgenic mice carrying intact HIV provirus: biological effects and organization of a transgene. J Acquir Immune Defic Syndr 5: 196–203PubMedGoogle Scholar
  3. Adachi A, Gendelman HE, Koenig S, Folks T, Willey R, Rabson A, Martin MA (1986) Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J Virol 59: 284–291PubMedGoogle Scholar
  4. Adler SH, Brüggeman LA, Kopp JB, Dorfman N, Bryant J, Eckhaus M, Notkins AL, Klotman PE (1992) Transcription of HIV-1 genes in transgenic mice is associated with myopathy and myositis. Int Conf AIDS 8: A48Google Scholar
  5. Agy MB, Frumkin LR, Corey L, Coombs RW, Wolinsky SM, Koehler J, Morton WR, Katze MG (1992) Infection of Macaca nemestrina by human immunodeficiency virus type-1. Science 257: 103–106PubMedCrossRefGoogle Scholar
  6. Ahmad N, Venkatesan S (1988) Nef protein of HIV-1 is a transcriptional repressor of HIV-1 LTR. Science 241: 1481–1485PubMedCrossRefGoogle Scholar
  7. Alonso A, Derse D, Peterlin BM (1992) Human chromosome 12 is required for optimal interactions between Tat and TAR of human immunodeficiency virus type 1 in rodent cells. J Virol 66: 4617–4621PubMedGoogle Scholar
  8. Alter HJ, Eichberg JW, Masur H, Saxinger WC, Gallo R, Macher AM, Lane HC, Fauci AS (1984) Transmission of HTLV-III infection from human plasma to chimpanzees: an animal model for AIDS. Science 226: 549–552PubMedCrossRefGoogle Scholar
  9. Bacchetti P, Moss AR (1989) Incubation period of AIDS in San Francisco. Nature 338: 251–253PubMedCrossRefGoogle Scholar
  10. Barré-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S, Gruest J, Dauguet C, Axler-Blin C, Vézinet-Brun F, Rouzioux C, Rozenbaum W, Montagnier L (1983) Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220: 868–871PubMedCrossRefGoogle Scholar
  11. Beral V, Peterman TA, Berkelman RL, Jaffe HW (1990) Kaposi’s sarcoma among persons with AIDS: a sexually transmitted disease? Lancet 335: 123–128PubMedCrossRefGoogle Scholar
  12. Biggar J, Burnett W, Mikl J, Nasca P (1989) Cancer among New York men at risk of acquired immunodeficiency syndrome. Int J Cancer 43: 979–985PubMedCrossRefGoogle Scholar
  13. Biggar RJ (1990) Cancer in acquired immunodeficiency syndrome: an epidemiological assessment. Semin Oncol 17: 251–260PubMedGoogle Scholar
  14. Biggar RJ, Horm J, Goedert JJ, Melbye M (1987) Cancer in a group at risk of acquired immunodeficiency syndrome (AIDS) through 1984. Am J Epidemiol 126: 578–586PubMedGoogle Scholar
  15. Booth W (1988) Of mice, oncogenes, and Rifkin. Science 239: 341–343PubMedCrossRefGoogle Scholar
  16. Bourgoignie JJ (1990) Renal complications of human immunodeficiency virus type 1. Kidney Int 37: 1571–1584PubMedCrossRefGoogle Scholar
  17. Bourgoignie JJ, Pardo V (1991) The nephropathology in human immunodeficiency virus (HIV-1) infection. Kidney Int 40: S19–S23Google Scholar
  18. Bovi PD, Donti E, Knowles DM II, Friedman-Kien A, Luciw PA, Dina D, Dalla-Favera R, Basilico C (1986) Presence of chromosomal abnormalities and lack of AIDS retrovirus DNA sequences in AIDS-associated Kaposi’s sarcoma Cancer Res 46: 6333–6338Google Scholar
  19. Boyle MJ, Sewell WA, Milliken ST, Cooper DA, Penny R (1993) HIV and malignancy. J Acquir Immune Defic Syndr 6: S5–S9PubMedGoogle Scholar
  20. Capetanaki Y, Smith S, Heath JP (1989) Overexpression of the vimentin gene in transgenic mice inhibits normal lens cell differentiation. J Cell Biol 109: 1653–1664PubMedCrossRefGoogle Scholar
  21. Cavard C, Zider A, Vernet M, Bennoun M, Saragosti S, Grimber G, Briand P (1990) In vivo activation by ultraviolet rays of the human immunodeficiency virus type 1 long terminal repeat. J Clin Invest 86: 1369–1374PubMedCrossRefGoogle Scholar
  22. Cheng-Mayer C, lannello P, Shaw K, Luciw PA, Levy JA (1989) Differential effects of nef on HIV replication: implications for viral pathogenesis in the host. Science 246: 1629–1632PubMedCrossRefGoogle Scholar
  23. Cohen AH, Nast CC (1988) HIV-associated nephropathy: a unique combined glomerular, tubular, and interstitial lesion. Mod Pathol 1: 87–97PubMedGoogle Scholar
  24. Cohen AH, Sun NCJ, Shapshak P, Imagawa DT (1989) Demonstration of human immunodeficiency virus in renal epithelium in HIV-associated nephropathy. Mod Pathol 2: 125–128PubMedGoogle Scholar
  25. Cullen BR (1986) Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism. Cell 46: 973–982PubMedCrossRefGoogle Scholar
  26. Curran JW (1983) AIDS: two years later. N Engl J Med 309: 609–611PubMedCrossRefGoogle Scholar
  27. Dalgleish AG, Beverley PCL, Clapham PR, Crawford DH, Greaves MF, Weiss RA (1984) The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312: 763–767PubMedCrossRefGoogle Scholar
  28. de Ronde A, Klaver B, Keulen W, Smit L, Goudsmit J (1992) Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes. Virology 188: 391–395PubMedCrossRefGoogle Scholar
  29. Dickie P, Felser J, Eckhaus M, Bryant J, Silver J, Marinos N, Notkins AL (1991) HIV-associated nephropathy in transgenic mice expressing HIV-1 genes. Virology 185: 109–119PubMedCrossRefGoogle Scholar
  30. Dingwall C, Ernberg I, Gait MJ, Green SM, Heaphy S, Kam J, Lowe AD, Singh M, Skinner MA, Valerio R (1989) Human immunodeficiency virus 1 Tat protein binds trans-activation-responsive region (TAR) RNA in vitro. Proc Natl Acad Sci USA 86: 6925–6929PubMedCrossRefGoogle Scholar
  31. Duvic M, Goldsmith LA (1983) HLA and skin disease. In: Goldsmith LA (ed) Dermatology in general medicine. Oxford University Press, New York, pp 915–998Google Scholar
  32. Duvic M, Johnson TM, Rapini RP, Freese T, Brewton G, Rios A (1987) Acquired immunodeficiency syndrome-associated psoriasis and Reiter’s syndrome. Arch Dermatol 123: 1622–1632PubMedCrossRefGoogle Scholar
  33. Eichberg JW, Zarling JM, Alter HJ, Levy JA, Berman PW, Gregory T, Lasky LA, McClure J, Cobb KE, Moran PA, Hu S-L, Kennedy RC, Chanh TC, Dreesman GR (1987) T-cell responses to human immunodeficiency virus (HIV) and its recombinant antigenes in HIV-infected chimpanzees. J Virol 61: 3804–3808PubMedGoogle Scholar
  34. Eichberg JW, Lee DR, Allan JS, Cobb KE, Barbosa LH, Nemo GJ, Prince AM (1988) In utero infection of an infant chimpanzee with HIV. N Engl J Med 319: 722–723PubMedCrossRefGoogle Scholar
  35. Ezzell C (1988) Laboratory accident kills AIDS mice. Nature 336: 613PubMedGoogle Scholar
  36. Feinberg MB, Baltimore D, Frankel AD (1991) The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation. Proc Natl Acad Sci USA 88: 4045–4049PubMedCrossRefGoogle Scholar
  37. Filice G, Cereda PM, Varnier OE (1988) Infection of rabbits with human immunodeficiency virus. Nature 335: 366–369PubMedCrossRefGoogle Scholar
  38. Francis ND, Parkin JM, Weber J, Boylston AW (1986) Kaposi’s sarcoma in acquired immune deficiency syndrome (AIDS). J Clin Pathol 39: 469–474PubMedCrossRefGoogle Scholar
  39. Frucht DM, Lamperth L, Vicenzi E, Belcher JH, Martin MA (1991) Ultraviolet radiation increases HIV-long terminal repeat-directed expression in transgenic mice. AIDS Res Hum Retroviruses 7: 729-@733PubMedCrossRefGoogle Scholar
  40. Fujikawa LS, Salahuddin SZ, Ablashi D, Palestine AG, Masur H, Nussenblatt RB, Gallo RC (1985) Human T-cell leukemia/lymphotropic virus type III in the conjunctival epithelium of a patient with AIDS. Am J Ophthalmol 100: 507–509PubMedGoogle Scholar
  41. Fujikawa LS, Salahuddin SZ, Ablashi D, Palestine AG, Masur H, Nussenblatt RB, Gallo RC (1986) HTLV-III in the tears of AIDS patients. Ophthalmology 93: 1479–1481PubMedGoogle Scholar
  42. Fultz PN (1991) Human immunodeficiency virus infection of chimpanzees: an animal model for asymptomatic HIV carriers and vaccine efficacy. In: Koff WC, Wong-Staal F, Kennedy RC (eds) AIDS research reviews. Dekker, New York, pp 207–218Google Scholar
  43. Fultz PN, Morrow WJW (1987) Experimental models of HIV infection In: Wormser GP, Stahl RE, Bottone EJ (eds) AIDS and other manifestations of HIV infection. Noyes Publications, Park Ridge, New Jersey, pp 257–269Google Scholar
  44. Fultz PN, McClure HM, Daugharty H, Brodie A, McGrath CR, Swenson B, Francis DP (1986a) Vaginal transmission of human immunodeficiency virus (HIV) to a chimpanzee. J Infect Dis 154: 896–900PubMedCrossRefGoogle Scholar
  45. Fultz PN, McClure HM, Swenson RB, McGrath CR, Brodie A,Getchell JP, Jensen FC, Anderson DC, Broderson JR, Francis DP (1986b) Persistent infection of chimpanzees with human T-lymphotropic virus type III/lymphadenopathy-associated virus: a potential model for acquired immunodeficiency syndrome. J Virol 58: 116–124PubMedGoogle Scholar
  46. Funke I, Hahn A, Rieber EP, Weiss E, Reithmüller G (1987) The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain. J Exp Med 165: 1230–1235PubMedCrossRefGoogle Scholar
  47. Gajdusek DC, Amyx HL, Gibbs CJ Jr, Asher DM, Rodgers-Johnson P, Epstein LG, Sarin PS, Gallo RC, Maluish A, Arthur LO, Montagnier L, Mildvan D (1985) Infection of chimpanzees by human T-lymphotropic retroviruses in brain and other tissues from AIDS patients. Lancet i: 55–56CrossRefGoogle Scholar
  48. Garcia JV, Miller AD (1991) Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature 350: 508–511PubMedCrossRefGoogle Scholar
  49. Gottlieb MS, Schroff R, Schanker HM, Weisman JD, Fan PT, Wolf RA, Saxon A (1981) Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. N Engl J Med 305: 1425–1431PubMedCrossRefGoogle Scholar
  50. Goudsmit J, Smit L, Krone WJA, Bakker M, van der Noordaa J, Gibbs CJ, Epstein LG, Gajdusek DC (1987) IgG response to human immunodeficiency virus in experimentally infected chimpanzees mimics the IgG response in humans. J Infect Dis 155: 327–331PubMedCrossRefGoogle Scholar
  51. Green JE, Hinrichs SH, Vogel J, Jay G (1989) Exocrinopathy resembling Sjögren’s syndrome in HTLV-1 fax transgenic mice. Nature 341: 72–74PubMedCrossRefGoogle Scholar
  52. Griep AE, Kuwabara T, Lee EJ, Westphal H (1989) Perturbed development of the mouse lens by polyomavirus large T antigen does not lead to tumor formation. Genes Dev 3: 1075–1085PubMedCrossRefGoogle Scholar
  53. Guy B, Kieny MP, Riviere Y, Le Peuch C, Dott K, Girard M, Montagnier L, Lecocq J-P (1987) HIV F/3′ orf encodes a phosphorylated GTP-binding protein resembling an oncogene product. Nature 330: 266–269PubMedCrossRefGoogle Scholar
  54. Guy B, Acres RB, Kieny MP, Lecocq J-P (1990) DNA binding factors that bind to the negative regulatory element of the human immunodeficiency virus-1: regulation by nef. J Acquir Immune Defic Syndr 3: 797–809PubMedGoogle Scholar
  55. Hammes SR, Dixon EP, Malim MH, Cullen BR, Greene WC (1989) Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor. Proc Natl Acad Sci USA 86: 9549–9553PubMedCrossRefGoogle Scholar
  56. Hart CE, Ou C-Y, Galphin JC, Moore J, Bacheler LT, Wasmuth JJ, Petteway SR Jr, Schochetman G (1989) Human chromosome 12 is required for elevated HIV-1 expression in human-hamster hybrid cells. Science 246: 488–491PubMedCrossRefGoogle Scholar
  57. Haseltine WA (1991) Human immunodeficiency virus (HIV) gene expression and function. In: Gallo RC, Jay G (eds) The human retroviruses. Academic, New York, pp 69–106Google Scholar
  58. Hauber J, Perkins A, Heimer EP, Cullen BR (1987) Trans-activation of human immunodeficiency virus gene expression is mediated by nuclear events. Proc Natl Acad Sci USA 84: 6364–6368PubMedCrossRefGoogle Scholar
  59. Hinrichs SH, Nerenberg M, Reynolds RK, Khoury G, Lay G (1987) A transgenic mouse model for human neurofibromatosis. Science 237: 1340–1343PubMedCrossRefGoogle Scholar
  60. Holland GN, Pepose JS, Pettit TH, Gottlieb MS, Yee RD, Foos RY (1983) Acquired immune deficiency syndrome: ocular manifestations. Ophthalmology 90: 859–873PubMedGoogle Scholar
  61. Homsy J, Meyer M, Tateno M, Clarkson S, Levy JA (1989) The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells. Science 244: 1357–1360PubMedCrossRefGoogle Scholar
  62. Iwakura Y, Shioda T, Tosu M, Yoshida E, Hayashi M, Nagata T, Shibuta H (1992) The induction of cataracts by HIV-1 in transgenic mice. AIDS 6: 1069–1075PubMedCrossRefGoogle Scholar
  63. Jabs DA, Green WR, Fox R, Polk BF, Bartlett JG (1989) Ocular manifestations of acquired immune deficiency syndrome. Ophthalmology 96: 1092–1099PubMedGoogle Scholar
  64. Jeang K-T, Shank PR, Kumar A (1988) Transcriptional activation of homologous viral long terminal repeats by the human immunodeficiency virus type 1 or the human T-cell leukemia virus type 1 tat proteins occurs in the absences of de novo protein synthesis. Proc Natl Acad Sci USA 85:8291–8295PubMedCrossRefGoogle Scholar
  65. Kaneshima H, Shih C-C, Namikawa R, Rabin L, Outzen H, Machado SG, McCune JM (1991) Human immunodeficiency virus infection of human lymph nodes in the SCID-hu mouse. Proc Natl Acad Sci USA 88: 4523–4527PubMedCrossRefGoogle Scholar
  66. Karlsson-Parra A, Dimény E, Fellström B, Klareskog L (1989) HIV receptors (CD4 antigen) in normal human glomerular cells. N Engl J Med 320: 741PubMedGoogle Scholar
  67. Karp JE, Broder S (1991) Acquired immunodeficiency syndrome and non-Hodgkin’s lymphomas. Cancer Res 51: 4743–4756PubMedGoogle Scholar
  68. Kestler HW III, Ringler DJ, Mori K, Panicali DL, Sehgal PK, Daniel MD, Desrosiers RC (1991) Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65: 651–662PubMedCrossRefGoogle Scholar
  69. Khillan JS, Oskarsson MK, Propst F, Kuwabara T, Vande Woude GF, Westphal H (1987) Defects in lens fiber differentiation are linked to c-mos overexpression in transgenic mice. Genes Dev 1: 1327–1335PubMedCrossRefGoogle Scholar
  70. Khillan JS, Deen KC, Yu S-H, Sweet RW, Rosenberg M, Westphal H (1988) Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice. Nucleic Acids Res 16: 1423–1430PubMedCrossRefGoogle Scholar
  71. Kim C-M, Koike K, Saito I, Miyamura T, Jay G (1991) HBxgene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351: 317–320PubMedCrossRefGoogle Scholar
  72. Kim S, Ikeuchi K, Byrn R, Groopman J, Baltimore D (1989) Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1. Proc Natl Acad Sci USA 86: 9544–9548PubMedCrossRefGoogle Scholar
  73. Klatzman D, Champagne E, Chamaret S, Gruest J, Guetard D, Hercend T, Gluckman J-C, Montagnier L (1984) T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 312: 767-768CrossRefGoogle Scholar
  74. Kopp JB, Klotman ME, Adler SH, Bruggeman LA, Dickie P, Marinos NJ, Eckhaus M, Bryant JL, Notkins AL, Klotman PE (1992) Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes. Proc Natl Acad Sci USA 89: 1577–1581PubMedCrossRefGoogle Scholar
  75. Kopp JB, Rooney JF, Wohlenberg C, Dorfman N, Marinos NJ, Bryant JL, Katz SI, Notkins AL, Klotman PE (1993) Cutaneous disorders and viral gene expression in HIV-1 transgenic mice. AIDS Res Hum Retroviruses 9: 267–275PubMedCrossRefGoogle Scholar
  76. Krueger GG (1981) Psoriasis: current concepts of its etiology and pathogenesis. In: Dobson RL, Theirs BH (eds) Yearbook in dermatology. Year Book Medical Publishers, Chicago, pp 13–70Google Scholar
  77. Kulaga H, Folks T, Rutledge R, Truckenmiller ME, Gugel E, Kindt TJ (1989) Infection of rabbits with human immunodeficiency virus 1: a small model for acquired immunodeficiency syndrome. J Exp Med 169: 321–326PubMedCrossRefGoogle Scholar
  78. Landau NR, Warton M, Littman DR (1988) The envelope glycoprotein of the human immunodeficiency virus binds to the immunoglobulin-like domain of CD4. Nature 334: 159–162PubMedCrossRefGoogle Scholar
  79. Laspia MF, Rice AP, Mathews MB (1989) HLV-1 Tat protein increases transcriptional initiation and stabilizes elongation. Cell 59: 283–292PubMedCrossRefGoogle Scholar
  80. Leonard JM, Abramczuk JW, Pezen DS, Rutledge R, Belcher JH, Hakim F, Shearer G, Lamperth L, Travis W, Fredrickson T, Notkins AL, Martin MA (1988) Development of disease and virus recovery in transgenic mice containing HIV proviral DNA. Science 242: 1665–1670PubMedCrossRefGoogle Scholar
  81. Levy JA, Cheng-Mayer C, Dina D, Luciw PA (1986) AIDS retrovirus (ARV-2) clone replicates in transfected human and animal fibroblasts. Science 232: 998–1001PubMedCrossRefGoogle Scholar
  82. Linial M, Blair D (1984) Genetics of retroviruses. In: Weiss R, Teich N, Varmus H, Coffin J (eds) RNA tumor viruses: molecular biology of tumor viruses, 2nd edn. Cold Spring Harbor Laboratory, New York, pp 649–783Google Scholar
  83. Locardi C, Puddu P, Ferrantini M, Parlanti E, Sestili P, Varano F, Belardelli F (1992) Persistent infection of normal mice with human immunodeficiency virus. J Virol 66: 1649–1654PubMedGoogle Scholar
  84. Luciw PA, Cheng-Mayer C, Levy JA (1987) Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication. Proc Natl Acad Sci USA 84: 1434–1438PubMedCrossRefGoogle Scholar
  85. Lui K-J, Darrow WW, Rutherford GW III (1988) A model-based estimate of the mean incubation period for AIDS in homosexual men. Science 240: 1333–1335PubMedCrossRefGoogle Scholar
  86. Lusso P, Markham PD, Ranki A, Earl P, Moss B, Dorner F, Gallo RC, Krohn KJE (1988) Cell-mediated immune response toward viral envelope and core antigens in gibbon apes (Hylobates lar) chronically infected with human immunodeficiency virus-1. J Immunol 141: 2467–2473PubMedGoogle Scholar
  87. Lusso P, di Marzo Veronese F, Ensoli B, Franchini G, Jemma C, DeRocco SE, Kalyanaraman VS, Gallo RC (1990) Expanded HIV-1 cellular tropism by phenotypic mixing with murine endogenous retroviruses. Science 247: 848–852PubMedCrossRefGoogle Scholar
  88. Macatonia SE, Lau R, Patterson S, Pinching AJ, Knight SC (1990) Dendritic cell infection, depletion and dysfuction in HIV-infected individuals. Immunology 71: 38–45PubMedGoogle Scholar
  89. Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, Axel R (1986) The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47: 333–348PubMedCrossRefGoogle Scholar
  90. Mahoney SE, Duvic M, Nickoloff BJ Minshall M, Smith LC, Griffiths CEM, Paddock SW, Lewis DE (1991) Human immunodeficiency virus (HIV) transcripts identified in HIV-related psoriasis and Kaposi’s sarcoma lesions. J Clin Invest 88: 174–185PubMedCrossRefGoogle Scholar
  91. Maitra RK, Ahmad N, Holland SM, Venkatesan S (1991) Human immunodeficiency virus type 1 (HIV-1) provirus expression and LTR transcription are repressed in NEF-expressing cell lines. Virology 182: 522–533PubMedCrossRefGoogle Scholar
  92. Mariani R, Skowronski J (1993) CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals. Proc Natl Acad Sci USA 90: 5549–5553.PubMedCrossRefGoogle Scholar
  93. Mathes BM, Douglass MC (1985) Seborrheic dermatitis in patients with acquired immunodeficiency syndrome. J Am Acad Dermatol 13: 947–951PubMedCrossRefGoogle Scholar
  94. Matis WL, Triana A, Shapiro R, Eldred L, Polk BF, Hood AF (1987) Dermatologic findings associated with human immunodeficiency virus infection. J Am Acad Dermatol 17: 746–751PubMedCrossRefGoogle Scholar
  95. McCune JM (1991) The SCID-hu mouse as a model for human immunodeficiency virus (HIV) infection. In: Gallo RC, Jay G (eds) The human retroviruses. Academic, New York, pp 295–316Google Scholar
  96. McCune JM, Namikawa R, Shih C-C, Rabin L, Kaneshima H (1990) Suppression of HIV infection in AZT-treated SCID-hu mice. Science 247: 564–566PubMedCrossRefGoogle Scholar
  97. McDougal JS, Kennedy MS, Sligh JM, Cort SP, Mawle A, Nicholson JKA (1986) Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule. Science 231: 382–385PubMedCrossRefGoogle Scholar
  98. McGrath MS, Shiramizu B, Meeker TC, Kaplan LD, Herndier B (1991) AIDS-associated polyclonal lymphoma: identification of a new HIV-associated disease process. J Acquir Immune Defic Syndr 4: 408–415PubMedGoogle Scholar
  99. Merrill JE, Chen ISY (1991) HIV-1, macrophages, glial cells, and cytokines in AIDS nervous system disease. FASEB J 5: 2391–2397PubMedGoogle Scholar
  100. Mitsuyasu RT (1988) AIDS-related Kaposi’s sarcoma: a review of its pathogenesis and treatment. Blood Rev 2: 222–231PubMedCrossRefGoogle Scholar
  101. Monroe JE, Calender A, Mulder C (1988) Epstein-Barr virus-positive and -negative B-cell lines can be infected with human immunodeficiency virus types 1 and 2. J Virol 62: 3497–3500PubMedGoogle Scholar
  102. Monteiro MJ, Hoffman PN, Gearhart JD, Cleveland DW (1990) Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber. J Cell Biol 111: 1543–1557PubMedCrossRefGoogle Scholar
  103. Morrey JD, Bourn SM, Bunch TD, Jackson MK, Sidwell RW, Barrows LR, Daynes RA, Rosen CA (1991) In vivo activation of human immunodeficiency virus type 1 long terminal repeat by UV type A (UV-A) light plus psoralen and UV-B light in the skin of transgenic mice. J Virol 65: 5045–5051PubMedGoogle Scholar
  104. Morrey JD, Bourn SM, Bunch TD, Sidwell RW, Rosen CA (1992) HIV-1 LTR activation model: evaluation of various agents in skin of transgenic mice. J Acquir Immune Defic Syndr 5: 1195–1203PubMedGoogle Scholar
  105. Morrow WJW, Wharton M, Lau D, Levy JA (1987) Small animals are not susceptible to human immunodeficiency virus infection. J Gen Virol 68: 2253–2257PubMedCrossRefGoogle Scholar
  106. Mosier DE (1991) SCID mice xenografted with human lymphoid cells as small-animal models for AIDS research. In: Koff WC, Wong-Staal F, Kennedy RC (eds) AIDS research reviews. Dekker, New York, pp 235–245Google Scholar
  107. Moskowitz LB, Hensley GT, Gould EW, Weiss SD (1985) Frequency and anatomic distribution of lymphadenopathic Kaposi’s sarcoma in the acquired immunodeficiency syndrome: an autopsy series. Hum Pathol 16: 447–456PubMedCrossRefGoogle Scholar
  108. Muesing MA, Smith DH, Capon DJ (1987) Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein. Cell 48: 691–701PubMedCrossRefGoogle Scholar
  109. Namikawa R, Kaneshima H, Lieberman M, Weissman IL, McCune JM (1988) Infection of the SCID-hu mouse by HIV-1. Science 242: 1648–1686CrossRefGoogle Scholar
  110. Nara PL, Robey WG, Arthur LO, Asher DM, Wolff AV, Gibbs CJ Jr, Gajdusek DC, Fischinger PJ (1987) Persistent infection of chimpanzees with human immunodeficiency virus: serological responses and properties of reisolated viruses. J Virol 61: 3173–3180PubMedGoogle Scholar
  111. Nara P, Hatch W, Kessler J, Kelliher J, Carter S (1989) The biology of human immunodeficiency virus-1 IIIB infection in the chimpanzee: in vivo and in vitro correlations. J Med Primatol 18: 343–355PubMedGoogle Scholar
  112. Newman NM, Mandel MR, Gullett J, Fujikawa L (1983) Clinical and histologic findings in opportunistic ocular infections: part of a new syndrome of acquired immunodeficiency. Arch Opthalmol 101: 396–401Google Scholar
  113. Pardo V, Aldana M, Colton RM, Fischl MA, Jaffe D, Moskowitz L, Hensley GT, Bourgoignie JJ (1984) Glomerular lesions in the acquired immunodeficiency syndrome. Ann Intern Med 101: 429–434PubMedGoogle Scholar
  114. Pardo V, Meneses R, Ossa L, Jaffe DJ, Strauss J, Roth D, Bourgoignie JJ (1987) AIDS-related glomerulopathy: occurrence in specific risk groups. Kidney Int 31: 1167–1173PubMedCrossRefGoogle Scholar
  115. Pepose JS, Holland GN, Nestor MS, Cochran AJ, Foos RY (1985) Acquired immune deficiency syndrome: pathogenic mechanisms of ocular disease. Ophthalmology 92: 472–484PubMedGoogle Scholar
  116. Pepose JS, Pardo F, Kessler J A II, Kline R, Donegan E, Quinn TC (1987) Screening cornea donors for antibodies against human immunodeficiency virus: efficacy of ELISA testing of cadaveric sera and aqueous humor. Ophthalmology 94: 95–100PubMedGoogle Scholar
  117. Pertel P, Hirschtick R, Phair J, Chmiel J, Poggensee L, Murphy R (1992) Risk of developing cytomegalovirus retinitis in persons infected with the human immunodeficiency virus. J Acquir Immune Defic Syndr 5: 1069–1074PubMedGoogle Scholar
  118. Pomerantz RJ, Kuritzkes DR, de la Monte SM, Rota TR, Baker AS, Albert D, Bor DH, Feldman EL, Schooley RT, Hirsch MS (1987) Infection of the retina by human immunodeficiency virus type I.N Engl J Med 317: 1643–1647PubMedCrossRefGoogle Scholar
  119. Popovic M, Samgadharan MG, Read E, Gallo RC (1984) Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 224: 497–500PubMedCrossRefGoogle Scholar
  120. Price RW, Brew B, Sidtis J, Rosenblum M, Scheck AC, Cleary P (1988) The brain in AIDS: central nervous systeem HIV-1 infection and AIDS dementia complex. Science 239: 586–592PubMedCrossRefGoogle Scholar
  121. Rao TKS, Friedman EA, Nicastri AD (1987) The types of renal disease in the acquired immunodeficiency syndrome. N Engl J Med 316: 1062–1068PubMedCrossRefGoogle Scholar
  122. Rosenberg ZF, Fauci AS (1991) Immunopathogenesis of HIV infection. FASEB J 5: 2382–2390PubMedGoogle Scholar
  123. Sadaie MR, Benter T, Wong-Staal F (1988) Site-directed mutagenesis of two trans-regulatory genes (tat-III, trs) of HIV-1. Science 239: 910–913PubMedCrossRefGoogle Scholar
  124. Safai B, Johnson KG, Myskowski PL, Koziner B, Yang SY, Cunningham-Rundles S, Godbold JH, Dupont B (1985) The natural history of Kaposi’s sarcoma in the acquired immunodeficiency syndrome. Ann Intern Med 103:744–750PubMedGoogle Scholar
  125. Salahuddin SZ, Palestine AG, Heck E, Ablashi D, Luckenbach M, McCulley JP, Nussenblatt RB (1986) Isolation of human T-cell leukemia/lymphotropic virus type III from the cornea. Am J Ophthalmol 101: 149–152PubMedGoogle Scholar
  126. Salahuddin SZ, Ablashi DV, Hunter EA, Gonda MA, Sturzenegger S, Markham PD, Gallo RC (1987) HTLV-III infection of EBV-genome-positive B-lymphoid cells with or without detectable T4 antigens. Int J Cancer 39: 198–202PubMedCrossRefGoogle Scholar
  127. Schnittman SM, Denning SM, Greenhouse JJ, Justement JS, Baseler M, Kurtzberg J, Haynes BF, Fauci AS (1990) Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR αβ+ and TCR γδ+ to human immunodeficiency virus: a mechanism for CD4+ (T4) lymphocyte depletion. Proc Natl Acad Sci USA 87: 7727–7731.PubMedCrossRefGoogle Scholar
  128. Skowronski J, Parks D, Mariani R (1993) Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. EMBO J 12: 703–713PubMedGoogle Scholar
  129. Small JA, Scangos GA, Cork L, Jay G, Khoury G (1986) The early regions of human papovavirus JC induces dysmyelination in transgenic mice. Cell 46: 13–18PubMedCrossRefGoogle Scholar
  130. Spector DH, Wade E, Wright DA, Koval V, Clark C, Jaquish D, Spector SA (1990) Human immunodefiency virus pseudotypes with expanded cellular and species tropism. J Virol 64: 2298–2308PubMedGoogle Scholar
  131. Strömland K, Miller M, Cook C (1991) Ocular teratology. Surv Ophthalmol 35: 429–446.PubMedCrossRefGoogle Scholar
  132. Takeda A, Tuazon CU, Ennis FA (1988) Antibody-enhanced infection by HIV-1 via Fc receptor-mediated entry. Science 242: 580–583PubMedCrossRefGoogle Scholar
  133. Terhorst C, van Agthoven A, Reinherz E, Schlossman S (1980) Biochemical analysis of human T lymphocyte differentiation antigens T4 and T5. Science 209: 520–521PubMedCrossRefGoogle Scholar
  134. Terwilliger E, Sodroski JG, Rosen CA, Haseltine WA (1986) Effects of mutations within the 3′ orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity. J Virol 60: 754–760PubMedGoogle Scholar
  135. Trono D, Baltimore D (1990) A human cell factor is essential for HIV-1 Rev action. EMBO J 9: 4155–4160PubMedGoogle Scholar
  136. Tschachler E, Groh V, Popovic M, Mann DL, Konrad K, Safai B, Eron L, diMarzo Veronese F, Wolff K, Stingl G (1987) Epidermal Langerhans cells: a target for HTLV-III/LAV infection. J Invest Dermatol 88: 233–237PubMedCrossRefGoogle Scholar
  137. Vogel J, Hinrichs SH, Reynolds RK, Luciw PA, Jay G (1988) The HIV tat gene induces dermal lesions resembling Kaposi’s sarcoma in transgenic mice. Nature 335: 606–611PubMedCrossRefGoogle Scholar
  138. Vogel J, Hinrichs SH, Napolitano LA, Ngo L, Jay G (1991) Liver cancer in transgenic mice carrying the human immunodeficiency virus tat gene. Cancer Res 51: 6686–6690PubMedGoogle Scholar
  139. Vogel J, Cepeda M, Tschachler E, Napolitano LA, Jay G (1992) UV activation of human immunodeficiency virus gene expression in transgenic mice. J Virol 66: 1–5PubMedGoogle Scholar
  140. Winchester R, Bernstein DH, Fischer HD, Enlow R, Solomon G (1987) The co-occurrence of Reiter’s syndrome and acquired immunodeficiency. Ann Int em Med 106: 19–26Google Scholar
  141. Wood GS, Warner NL, Warnke RA (1983) Anti-Leu-3/T4 antibodies react with cells of monocyte/ macrophage and Langerhans lineage. J Immunol 131: 212–216PubMedGoogle Scholar
  142. Wright CM, Felber BK, Paskalis H, Pavlakis GN (1986) Expression and characterization of the trans-activator of HTLV-III/LAV virus. Science 234: 988–992PubMedCrossRefGoogle Scholar
  143. Zazopoulos E, Haseltine WA (1993) Effect of nef alleles on replication of human immunodeficiency virus type 1. Virology 194: 20–27PubMedCrossRefGoogle Scholar
  144. Ziegler JL, Templeton AC, Vogel CL (1984) Kaposi’s sarcoma: a comparison of classical, endemic, and epidemic forms. Semin Oncol 11: 47–52PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • B. T. Tinkle
    • 1
  • H. Ueda
    • 1
  • G. Jay
    • 1
    • 2
  1. 1.Department of VirologyJerome H. Holland LaboratoryRockvilleUSA
  2. 2.Graduate Program in GeneticsGeorge Washington UniversityWashington, DCUSA

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