The Pathogenic Role of Human Immunodeficiency Virus Accessory Genes in Transgenic Mice

  • B. T. Tinkle
  • H. Ueda
  • G. Jay
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 193)


Human immunodeficiency virus (HIV) type 1, the causative agent of acquired immune deficiency syndrome (AIDS), was isolated almost a decade ago (Barré-Sinoussi et al. 1983; Popovic et al. 1984). HIV infection is mediated by the binding of the virus to the CD4 cell surface molecule and subsequent viral penetration (Dalgleish et al. 1984; Klatzmann et al. 1984; McDougal et al. 1986). Cells known to bear CD4 include the T-helper/inducer cells (Terhorst et al. 1980), immature thymocytes (Schnittman et al. 1990), Epstein-Barr virus (EBV)+ B lymphoblastoid cells (Dalgleish et al. 1984; Salahuddin et al. 1987; Monroe et al. 1988), monocytes/macrophages (Wood et al. 1983; Dalgleish et al. 1984), follicular dendritic cells (Wood et al. 1983; Macatonia et al. 1990), Langerhans cells (Wood et al. 1983; Tschachler et al. 1987), astrocytes (Funke et al. 1987), neurons (Funke et al. 1987), and glomerular mesangial cells (KARLSSON-PARRA et al. 1989).


Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Acquire Immune Deficiency Syndrome Acquire Immune Deficiency Syndrome Patient Human Immunodeficiency Virus Protein 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • B. T. Tinkle
    • 1
  • H. Ueda
    • 1
  • G. Jay
    • 1
    • 2
  1. 1.Department of VirologyJerome H. Holland LaboratoryRockvilleUSA
  2. 2.Graduate Program in GeneticsGeorge Washington UniversityWashington, DCUSA

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