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HTLV-1 Oncoprotein Tax and Cellular transcription Factors

  • M. Yoshida
  • T. Suzuki
  • J. Fujisawa
  • H. Hirai
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 193)

Abstract

Human T cell leukemia virus (HTLV) type 1 (Poiesz et al. 1980; Yoshida et al. 1982) has two regulatory genes, tax and rex, that control the viral gene expression and replication positively and negatively (Seiki et al. 1983; Inoue et al. 1987; Hidaka et al. 1988). In these regulations, tax activates transcription of the viral genome, whereas rex modulates the processing of the viral RNA expressing unspliced forms of the viral mRNA; therefore, both regulators are indispensable for efficient viral replication.

Keywords

Serum Response Factor Cellular Transcription Factor Tropical Spastic Paraparesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • M. Yoshida
    • 1
  • T. Suzuki
    • 1
  • J. Fujisawa
    • 1
  • H. Hirai
    • 1
  1. 1.Department of Cellular and Molecular BiologyInstitute of Medical Science, The University of TokyoTokyoJapan

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