HTLV-1 Oncoprotein Tax and Cellular transcription Factors
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Human T cell leukemia virus (HTLV) type 1 (Poiesz et al. 1980; Yoshida et al. 1982) has two regulatory genes, tax and rex, that control the viral gene expression and replication positively and negatively (Seiki et al. 1983; Inoue et al. 1987; Hidaka et al. 1988). In these regulations, tax activates transcription of the viral genome, whereas rex modulates the processing of the viral RNA expressing unspliced forms of the viral mRNA; therefore, both regulators are indispensable for efficient viral replication.
KeywordsSerum Response Factor Cellular Transcription Factor Tropical Spastic Paraparesis
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