• L. Ratner
  • T. M. J. Niederman
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 193)


The nef gene is present in all human and simian immunodeficiency retroviruses, suggesting an important function during natural infection (Fig. 1). A homologous gene, bel 3, is also present in human spumaretroviruses (Maurer and Flugel 1987). The importance of nef sequence conservation has been confirmed by studies with SIVmic in rhesus macaques in which an intact nef gene was found to be important for continuous virus replication in vivo and for the development of AIDS. However, considerable heterogeneity is found in the nef gene, with levels of sequence variation comparable to that of the gp120 surface envelope protein.


Human Immunodeficiency Virus 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • L. Ratner
    • 1
  • T. M. J. Niederman
    • 1
  1. 1.Departments of Medicine and Molecular MicrobiologyWashington University School of MedicineSt. LouisUSA

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