Skip to main content

Neuropeptides (Neurokinins, Bombesin, Neurotensin, Cholecystokinins, Opioids) and Smooth Muscle

  • Chapter
Pharmacology of Smooth Muscle

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 111))

Abstract

Five groups of linear biopolymers, composed of amino acid residues and called neuropeptides, are considered in this chapter. The primary structure of a prototype of each group is shown in Table 1. The sequences were initially identified in animals and subsequently all of them were also found in man.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ahmad S, Allescher HD, Kwan CY (1991) Receptors for neuropeptides: ligand-binding studies. In: Daniel EE (ed) Neuropeptide function in gastrointestinal tract. CRC, Boca Raton, pp 209–229

    Google Scholar 

  • Allescher HD, Ahmad S (1991) Postulated physiological and pathophysiological roles in motility. In: Daniel EE (ed) Neuropeptide function in the gastrointestinal tract. CRC, Boca Raton, pp 309–400

    Google Scholar 

  • Allescher HD, Kostolanska F, Tougas G, Fox JET, Regoli D, Drapeau D, Daniel EE (1989) The action of neurokinin and substance P receptors in canine pylorus, antrum and duodenum. Peptides 10:671–679

    Article  PubMed  CAS  Google Scholar 

  • Altar CA, Boyar WC (1989) Brain CCK-B receptors mediate the suppression of dopamine release by cholecystokin. Brain Res 483:321–326

    Article  PubMed  CAS  Google Scholar 

  • Anastasi A, Erspamer V, Endean R (1967) Isolation and structure of caerulein, an active decapeptide from the skin of Hyla coerulea. Experientia 23:699–703

    Article  PubMed  CAS  Google Scholar 

  • Andersson KE, Andersson R, Hedner R (1972) Cholecystokinetic effect and concentration of cyclic AMP in gall bladder in vitro. Acta Physiol Scand 85:511–516

    Article  PubMed  CAS  Google Scholar 

  • Aoki K, Kajiwara M, Oka T (1986) The inactivation of [Met5]-enkephalin by bestatin-sensitive aminopeptidase, captopril-sensitive peptidyl dipeptidase A and thiorphan-sensitive endopeptidase-24.11 in mouse vas deferens. Jpn J Pharmacol 40:297–302

    Article  PubMed  CAS  Google Scholar 

  • Araki K, Tachibana S, Uchiyama M, Nakajima T, Yasuhara T (1973) Isolation and structure of a new active peptide “Xenopsin” on the smooth muscle especially on a strip of fundus from a rat stomach, from the skin of Xenopus laevis. Chem Pharm Bull (Tokyo) 21:2801–2804

    Article  CAS  Google Scholar 

  • Armstrong MJ, Parker MC, Ferris CF, Leeman SE (1986) Neurotensin stimulates (3H) oleic acid translocation across rat small intestine. Am J Physiol 251: G823–G829

    PubMed  CAS  Google Scholar 

  • Atkins HL, Oster ZH (1989) Asymetric gall bladder contraction following chol-ecystokinin hepatobiliary imaging. Chem Nucl Med 14:82–86

    Article  CAS  Google Scholar 

  • Barabé J, Park WK, Regoli D (1975) Application of drug-receptor theories to the analysis of the myotropic effects of bradykinin. Can J Physiol Pharmacol 53: 345–353

    Article  PubMed  Google Scholar 

  • Bauer AJ, Szursweski JH (1989) Dynorphin presynaptically inhibits neuro muscular transmission via delta opioid receptors in circular muscle of canine duodenum (Abstr). Gastroenterology 96:A33

    Google Scholar 

  • Behar J, Biancani P (1977) Effect of cholecystokinin octapeptide on lower esophageal sphincter. Gastroenterology 73:57–61

    PubMed  CAS  Google Scholar 

  • Behar J, Biancani P (1980) Effect of cholecystokinin and the octapeptide cholecystokinin on the feline sphincter of Oddi and gall bladder; Mechanism of action. J Clin Invest 66:1231–1239

    Article  PubMed  CAS  Google Scholar 

  • Bennett A, Misiewicz JJ, Waller SL (1967) Analysis of the motor effect of gastrin and pentagastrin on the human alimentary tract in vitro. Gut 8:470–474

    Article  PubMed  CAS  Google Scholar 

  • Bertaccini G (1976) Active polypeptides of non-mammalian origin. Pharmacol Rev 28:127–177

    PubMed  CAS  Google Scholar 

  • Bertaccini G, Erspamer V, Impicciatore H (1973) The actions of bombesin on gastric secretion of the dog and rat. Br J Pharmacol 49:437–444

    PubMed  CAS  Google Scholar 

  • Bertaccini G, Erspamer V, Melchiorri P, Sopranzi N (1974) Gastrin release by bombesin in the dog. Br J Pharmacol 52:219–225

    PubMed  CAS  Google Scholar 

  • Bitar KN, Burgess GM, Putney JW Jr, Makhlouf GM (1986) Source of activator calcium in isolated guinea pig and human gastric smooth muscle cells. Am J Physiol 250.G280

    PubMed  CAS  Google Scholar 

  • Blundell J (1991) Pharmacological approaches to appetite suppression. Trends Pharmacol Sci 12:147–157

    Article  PubMed  CAS  Google Scholar 

  • Borison HL (1971) Sites of action of narcotic analgesic drugs: the nervous system. In: Clouet DE (ed) Narcotic drugs: biochemical pharmacology. Plenum, New York

    Google Scholar 

  • Borson DB (1991) Roles of neutral endopeptidases in airways. Am J Physiol 260: L212–L225

    PubMed  CAS  Google Scholar 

  • Brizzolara A, Burnstock G (1991) Endothelium dependent and endothelium independent vasodilatation of the hepatic artery of the rabbit. Br J Pharmacol 103:1206–1212

    PubMed  CAS  Google Scholar 

  • Brown MR, River J, Vale WW (1977) Bombesin: potent effect on thermoregulation in the rat. Science 196:988–990

    Google Scholar 

  • Brown MR, Taché Y, Fisher D (1979) Central nervous system action of bombesin: mechanism to induce hyperglycemia. Endocrinology 105:660–665

    Article  PubMed  CAS  Google Scholar 

  • Bunnet NW, Reeve JR, Walsh JH (1983) Catabolism of bombesin in the interstitial fluid of the rat stomach. Neuropeptides 4:55–64

    Article  Google Scholar 

  • Bunnet NW, Kobayashi R, Orloff MS, Reeve JR, Turner AJ, Walsh JH (1985) Catabolism of gastrin-releasing peptide and substance P by gastric membrane- bound peptidases. Peptides 6:277–283

    Article  Google Scholar 

  • Burnstock G (1970) Structure of smooth muscle and its innervation. In: Bulbring E, Brading A, Jones A, Tomita T (eds) Smooth muscle. Arnold, London, pp 1–69

    Google Scholar 

  • Busse R, Mulsch A (1990) Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin. FEBS Lett 265:133–134

    Article  PubMed  CAS  Google Scholar 

  • Cameron AJ, Phillips SF, Summerskill WHJ (1967) Effect of cholecystokinin on motility of human stomach and gall bladder muscle in vitro. Clin Res 15:416

    Google Scholar 

  • Campbell C, Phillips DC, Frazier TM (1961) Analgesia during labor: a comparison of pentobarbital, meperidine and morphine. Obstet Gynecol 17:714–718

    PubMed  CAS  Google Scholar 

  • Cantor P, Holst JJ, Knuhtsen S, Rehfeld JF (1987) Effect of neuroactive agents in cholecystokinin release from the isolated perfused porcine duodenum. Acta Physiol Scand 130:627–632

    Article  PubMed  CAS  Google Scholar 

  • Caprilli R, Melchiorri P, Improta G, Vernia P, Fried G (1975) Effects of bombesin and bombesin-like peptides on gastrointestinal myoelectric activity in the dog. Gastroenterology 68:1228–1235

    PubMed  CAS  Google Scholar 

  • Carraway RE, Leeman SE (1973) The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami. J Biol Chem 248:6854–6861

    PubMed  CAS  Google Scholar 

  • Carraway RE, Leeman SE (1975) Structural requirements for the biological activity of neurotensin, a new vasoactive peptide. In: Walter R, Meienhofer J (eds) Peptide chemistry, structure and biology. Ann Arbor Sci, Ann Arbor, p 679

    Google Scholar 

  • Carraway RE, Cochrane DE, Lansoman JB, Leeman SE, Paterson BM, Welch HJ (1982) Neurotensin stimulates exocytic histamine secretion from rat mast cells and elevates plasma histamine levels. J Physiol (Lond) 323:404–414

    Google Scholar 

  • Chang MM, Leeman SE (1970) Isolation of a sialogogic peptide from bovine hypothalamic tissue and its characterization as substance P. J Biol Chem 245:4784–4790

    PubMed  CAS  Google Scholar 

  • Chang RS, Lotti VJ (1986) Biochemical and pharmacological characterization of a new extremely potent and selective non peptide cholecystokinin antagonist. Proc Natl Acad Sci USA 83:4923–4926

    Article  PubMed  CAS  Google Scholar 

  • Chang RS, Lotti VJ (1988) A review of the biological and pharmacological characterization of a highly peripherally selective CCK antagonists L-364;718. In: Wang RY, Schoenfeld R (eds) Cholescytokinin Antagonists. Liss, New York, pp 13–28

    Google Scholar 

  • Chang RS, Lotti VJ (1991) Ligands for cholecystokinin A and choecystokinin B/gastrin receptors. In: Conn PM (ed) Methods in neurosciences. Academic, Orlando, 5:479–493

    Google Scholar 

  • Checler F (1991) Peptidases and neuropeptide-inactivating mechanisms in the circulation and gastrointestinal tract. In: Daniel EE (ed) Neuropeptide function in the gastrointestinal tract. CRC, Boca Raton, pp 273–307

    Google Scholar 

  • Checler F, Kostolanska B, Fox JET (1988) In vivo inactivation of neurotensin in dog ileum: major involvement of endopeptidase 24–11. J Pharmacol Exp Ther 244:1040–1044

    PubMed  CAS  Google Scholar 

  • Cheng YC, Prusoff WH (1973) Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 percent inhibition (I50) of an enzymatic reaction. Biochem Pharmacol 22:3099–3108

    Article  PubMed  CAS  Google Scholar 

  • Cherubini E, North RA (1985) Mu and kappa opioids inhibit transmitter release by different mechanisms. Proc Natl Acad Sci USA 82:1860–1863

    Article  PubMed  CAS  Google Scholar 

  • Chowdhury JR, Berkowitz JM, Praissman M, Fara JW (1975) Interaction between octapeptide cholecystokinin, gastrin and secretin on cat gall bladder in vitro. Am J Physiol 229:1311–1315

    PubMed  CAS  Google Scholar 

  • Christinck F, Daniel EE, Fox JET (1989) Electrophysiological responses of canine ileal circular muscle to electrical stimulation and neurotensin (NT) (Abstr). Gastroenterology 96:A680

    Google Scholar 

  • Clark WG (1981) Effects of opioid peptides on thermoregulation. Fed Proc 40: 2754–2759

    PubMed  CAS  Google Scholar 

  • Cohen ML, Geary LE, Wiley KS (1983) Enkephalin degradation in the guinea pig ileum: effect of aminopeptidase inhibitors, puromycin and bestatin. J Pharmacol Exp Ther 224:379–385

    PubMed  CAS  Google Scholar 

  • Constantine JW, Lebel WS, Woody HA (1990) Smooth muscle of rabbit isolated aorta contains the NK-2 tachykinin receptor. Naunyn Schmiedebergs Arch Pharmacol 342:722–724

    Article  PubMed  CAS  Google Scholar 

  • Cotton R, Giles MG, Miller L, Shaw JS, Timms D (1984) ICI 174864: a highly-selective antagonist for the opioid δ-receptor. Eur J Pharmacol 97:331–332

    Article  PubMed  CAS  Google Scholar 

  • Couture R, Cuello AC (1984) Plasma protein extravasation induced by mammalian tachykinins in the rat skin: influence of anaesthetic agents and an acetylcholine antagonist. Br J Pharmacol 91:265–273

    Google Scholar 

  • Couture R, Regoli D (1982) Smooth muscle pharmacology of substance P. Pharmacology 24:1–25

    Article  PubMed  CAS  Google Scholar 

  • Couture R, Mizrahi J, Regoli D, Devroede G (1981) Peptides and the human colon: an in vitro pharmacological study. Can J Physiol Pharmacol 59:957–964

    Article  PubMed  CAS  Google Scholar 

  • Couture R, Laneuville O, Guimond C, Drapeau G, Regoli D (1989) Characterization of the peripheral action of neurokinins and neurokinin receptor selective agonists on the rat cardiovascular system. Naunyn Schmiedebergs Arch Pharmacol 340:547–557

    Article  PubMed  CAS  Google Scholar 

  • Crawley JN (1991) Cholecystokinin-dopamine interactions. Trends Pharmacol Sci 12:232–236

    Article  PubMed  Google Scholar 

  • Crochelt RF, Peikin SR (1986) Characterization of Ca channels mediating gall bladder contraction in the guinea pig (Abstr). Gastroenterology 90:1787

    Google Scholar 

  • Crossman DC, Larkin S, Fuller RW, Davies GJ, Maseri A (1989) Substance P dilates epicardial coronary arteries and increases coronary blood flow in humans. Circulation 80:475–484

    Article  PubMed  CAS  Google Scholar 

  • D’Orléans-Juste P, Dion S, Mizrahi J, Regoli D (1985) Effects of peptides and nonpeptides on isolated arterial smooth muscles: role of endothelium. Eur J Pharmacol 114:9–21

    Article  PubMed  Google Scholar 

  • D’Orléans-Juste P, Dion S, Drapeau G, Regoli D (1986) Different receptors are involved in the endothelium-mediated relaxation and the smooth muscle contraction of the rabbit pulmonary artery in response to substance P and related neurokinins. Eur J Pharmacol 125:37–44

    Article  PubMed  Google Scholar 

  • De Montigny C (1989) Cholecystokinin tetrapeptide induces panick attacks in healthy volunteers: preliminary findings. Arch Gen Psychiatry 46:511–517

    Article  PubMed  Google Scholar 

  • Deblois D, Marceau F (1987) The ability of des-Arg9-bradykinin to relax rabbit isolated mesenteric arteries is acquired during in vitro incubation. Eur J Pharmacol 142:141–144

    Article  PubMed  CAS  Google Scholar 

  • Dion S, D’Orléans-Juste P, Drapeau G, Rhaleb NE, Rouissi N, Tousignant C, Regoli D (1987) Characterization of neurokinin receptors in various isolated organs by the use of selective agonists. Life Sci 41:2269–2278

    Article  PubMed  CAS  Google Scholar 

  • Dion S, Corcos J, Carmel M, Drapeau G, Regoli D (1988) Substance P and neurokinins as stimulants of the human isolated urinary bladder. Neuropeptides 11:83–87

    Article  PubMed  CAS  Google Scholar 

  • Dobner PR, Barber DL, Villa-Komaroff L, McKiernan C (1987) Cloning and sequence analysis of cDNA from the canine neurotensin/neuromedin N precursor. Proc Natl Acad Sci USA 84:3516–3520

    Article  PubMed  CAS  Google Scholar 

  • Dockray GJ, Dimaline R, Pauwels S, Varro A (1989) Gastrin and CCK-related peptides. In: Martinez J (ed) Peptide hormones and prohormones. Harwood, Chichester, pp 244–284

    Google Scholar 

  • Dourish CT, Hawley D, Iversen SD (1988) Enhancement of morphine analgesia and prevention of morphine tolerance in the rat by cholecystokinin antagonist L 364 718. Eur J Pharmacol 147:469–472

    Article  PubMed  CAS  Google Scholar 

  • Drapeau G, Rouissi N, Nantel F, Rhaleb NE, Tousignant C, Regoli D (1990) Antagonists for the neurokinin NK-3 receptor evaluated in selective receptor systems. Regul Pept 31:125–135

    Article  PubMed  CAS  Google Scholar 

  • Edkins JS (1905) On the chemical mechanism of gastric secretion. Proc R Soc Lond [B] 76:376

    Article  Google Scholar 

  • Ekblad E, Hakanson R, Sundler F (1991) Microanatomy and chemical coding of peptide containing neurons in the digestive tract. In: Daniel EE (ed) Neuropeptide function in the gastrointestinal tract. CRC, Boca Raton, pp 131–179

    Google Scholar 

  • Eng J, Shiina Y, Pan YC, Blacher R, Chang M, Stein S, Yalow R (1983) Pig brain contains cholecystokinin octapeptide and several cholecystokinin desoct-apeptides. Proc Natl Acad Sci USA 80:6381–6385

    Article  PubMed  CAS  Google Scholar 

  • Erspamer V, Melchiorri P (1980) Active polypeptides: from amphibian skin to gastrointestinal tract and brain of mammals. Trends Pharmacol Sci 1:391–395

    Article  CAS  Google Scholar 

  • Erspamer V, Falconieri Erspamer G, Inselvini M (1970) Some pharmacological actions of alytesin and bombesin. J Pharm Pharmacol 22:875–876

    Article  PubMed  CAS  Google Scholar 

  • Erspamer V, Falconieri-Erspamer G, Inselvini M, Negri L (1972) Occurence of bombesin and alytesin in extracts of the skin of three European discoglossid frogs and pharmacological actions of bombesin on extravascular smooth muscle. Br J Pharmacol 45:333–348

    PubMed  CAS  Google Scholar 

  • Erspamer V, Improta G, Melchiorri P, Sopranzi N (1974) Evidence of cholecystokinin release by bombesin in dog. Br J Pharmacol 52:227–232

    PubMed  CAS  Google Scholar 

  • Eysselein VE, Reeve JR Jr, Shively JE, Miller C, Walsh JH (1984) Isolation of a large cholecystokinin precursor from canine brain. Proc Natl Acad Sci USA 81:6565–6568

    Article  PubMed  CAS  Google Scholar 

  • Falconieri-Erspamer G, Serverini C, Erspamer V, Melchiorri P, Dellefave G, Nakajima J (1988) Parallel bioassay of 27 bombesin like peptides on 9 smooth muscle preparations. Structure-activity relationships and bombesin receptor subtypes. Regul Pept 21:1–11

    Article  PubMed  CAS  Google Scholar 

  • Fox JET, Daniel EE (1986) Substance P a potent inhibitor of the canine small intestine in vivo. Am J Physiol 250:G21–G27

    PubMed  CAS  Google Scholar 

  • Frazer HF, Nash TL, Vanhorn GD, Isbell M (1954) Use of miotic effect in evaluating analgesic drugs in man. Arch Int Pharmacodyn Ther 98:443–451

    Google Scholar 

  • Friedlinger RM (1989) Nonpeptide ligands for peptide receptors. Trends Pharmacol Sci 10:270–274

    Article  Google Scholar 

  • Fukuda H, Hosoki E, Ishida Y, Moritoki H (1985) Opioids receptor types on adrenergic nerve terminals of rabbit ear artery. Br J Pharmacol 86:539–545

    PubMed  CAS  Google Scholar 

  • Furchgott RF (1981) The requirement of endothelial cells in the relaxation of arteries by acetylcholine and some other vasodilators. Trends Pharmacol Sci 3:173–175

    Article  Google Scholar 

  • Furness JB, Costa M (1987) The enteric nervous system. Churchill Livingstone, Edinburgh

    Google Scholar 

  • Gafford JT, Skidgel RA, Erdos EG, Hersh LBC (1983) Human kidney “en-kephalinase”, a neutral metalloendopeptidase that cleaves active peptides. Biochemistry 22:3265–3271

    Article  PubMed  CAS  Google Scholar 

  • Gen MC, Valdman AV (1967) Experimental observations on the pharmacology of the pontine respiration center. Prog Brain Res 20:148–170

    Article  PubMed  CAS  Google Scholar 

  • Gerner T, Haffner JFW (1977) The role of local cholinergic pathways in the motor responses to cholecystokinin and gastrin in isolated guinea pig fundus and antrum. Scand J Gastroenterol 12:751–757

    Article  PubMed  CAS  Google Scholar 

  • Gibbs J, Fauser DJ, Rowe EA, Rolls BJ, Rolls ET, Maddison SP (1979) Bombesin suppresses feeding in rats. Nature 282:208–210

    Article  PubMed  CAS  Google Scholar 

  • Gilbert PE, Martin WR (1976) The effects of morphine and nalorphine-like drugs in the non-dependent, morphine-dependent and cycazocine-dependent chronic spinal dog. J Pharmacol Exp Ther 198:66–82

    PubMed  CAS  Google Scholar 

  • Gillan MG, Kosterlitz HW, Magnan J (1981) Unexpected antagonism in the rat vas deferens by benzo-morphans which are agonists in other pharmacological tests. Br J Pharmacol 72:13–15

    PubMed  CAS  Google Scholar 

  • Gintzler AR, Scalisi JA (1982) Effects of opioids on non-cholinergic excitatory responses of the guinea pig isolated ileum: inhibition of the release of enteric substance P. Br J Pharmacol 75:199–205

    PubMed  CAS  Google Scholar 

  • Girard F, Bachelard H, St-Pierre S, Rioux F (1984) The contractile effect of bombesin, gastrin releasing peptide and various fragments in the rat stomach strip. Eur J Pharmacol 102:489–497

    Article  PubMed  CAS  Google Scholar 

  • Goedert M, Hunter JC, Ninkovic M (1984) Evidence for neurotensin as a non-adrenergic, non-cholinergic neurotransmitter in guinea pig ileum. Nature 311:59–62

    Article  PubMed  CAS  Google Scholar 

  • Green J, Nunley C, Anderson NG (1966) High-pressure column chromatography. I. Design of apparatus and separation of bases, nucleosides and nucleotides. Natl Cancer Inst Monogr 21:431–440

    PubMed  CAS  Google Scholar 

  • Gridger JR, Makhlouf GM (1987) Regional and cellular heterogeneity of CCK receptors mediating muscle contraction in the gut. Gastroenterology 92:175–180

    Google Scholar 

  • Grundy HF (1971) Cardiovascular effects of morphine, pethidine, dismorphine and nalorphine on the cat and rabbit. Br J Pharmacol 42:159–178

    PubMed  CAS  Google Scholar 

  • Guard S, Watson SP (1991) Tachykinin receptor types: classification and membrane signaling mechanisms. Neurochem Int 18:149–165

    Article  PubMed  CAS  Google Scholar 

  • Gulati N, Mathison R, Huggel H, Regoli D, Beny JL (1987) Effects of neurokinins on the isolated pig coronary artery. Eur J Pharmacol 137:149–154

    Article  PubMed  CAS  Google Scholar 

  • Guo YS, Singh P, Lluis F, Gomez G, Thompson JC (1986) Contractile response of gallbladder and sphincter of Oddi to substance P and related peptides compared to CCK-8 (Abstr). Fed Proc 45:291

    Google Scholar 

  • Hammer RA, Leeman SE, Carraway R, Williams RH (1980) Isolation of human intestinal neurotensin. J Biol Chem 255:2476–2480

    PubMed  CAS  Google Scholar 

  • Hanko JM, Hardebeo JE (1978) Enkephalin-induced dilatation of pial arteries probably mediated by opiate receptors. Eur J Pharmacol 51:295–297

    Article  PubMed  CAS  Google Scholar 

  • Harper AA, Raper HS (1943) Pancreazymin, a stimulant of the secretion of pancreatic enzymes in extracts of the small intestine. J Physiol (Lond) 102:115–125

    CAS  Google Scholar 

  • Heimbrook DC, Saari WS, Balishin NL, Friedman A, Moore KS, Riemen MW, Kiefer DM, Rotberg NS, Wallen JW, Oliff A (1989) Carboxyl-terminal modification of a gastrin derivative generates potent antagonists. J Biol Chem 264: 11258–11262

    PubMed  CAS  Google Scholar 

  • Heike CJ, Krause JE, Mantyh PW, Couture R, Bannon MJ (1990) Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors and regulatory mechanisms. FASEB J 4:1606–1615

    Google Scholar 

  • Hökfelt T (1986) Coexistence of neuronal messengers: a new principle in chemical transmission. In: Fuxe K, Pernow B (eds) Progress in brain research, 68, Elsevier, Amsterdam

    Google Scholar 

  • Hökfelt T, Herrera-Marschitz M, Seroogy K, Ju G, Staines WA, Holets V, Schalling M, Ungerstedt U, Post C, Rehfeld JF (1988) Immunohistochemical studies on cholecystokinin (CCK)-immunoreactive neurons in the rat using sequence specific antisera and with special reference to the candate nucleus and primary sensory neurons. J Chem Neuroanat 1:11–51

    PubMed  Google Scholar 

  • Hua X, Lundberg JM, Theodorsson-Norheim E, Brodin E (1984) Comparison of cardiovascular and bronchosonstrictor effects of substance P, substance P, substance K and other tachykinins. Naunyn Schmiedebergs Arch Pharmacol 328: 196–201

    Article  PubMed  CAS  Google Scholar 

  • Hughes J, Smith TW, Kosterlitz HW, Fathergill LH, Morgan BA, Morris HR (1975) Identification of two related pentapeptides from the brain with potent opioid agonist activity. Nature 258:577–580

    Article  PubMed  CAS  Google Scholar 

  • Ignarro LJ (1989) Endothelium-derived nitric oxide actions and properties. FASEB J 3:31–36

    PubMed  CAS  Google Scholar 

  • Innis RB, Snyder SH (1980) Distinct cholecystokinin receptors in brain and pancreas Proc Natl Acad USA 77:6917–6921

    Article  CAS  Google Scholar 

  • Ireland SJ, Hagan RM, Bailey F, Jordan CC, Stephens-Smith ML (1990) Receptors mediating neurokinin-induced contractions of the guinea-pig trachea. Br J Pharmacol 99.63P

    Google Scholar 

  • Ireland SJ, Bailey F, Cook A, Hagan RM, Jordan CC, Stephens-Smith ML (1991) Receptors mediating tachykinin-induced contractile responses in guinea pig trachea. Br J Pharmacol 103:1463–1469

    PubMed  CAS  Google Scholar 

  • Isenberg JI, Cseudes A (1972) Effect of octapeptide of cholecystokinin on canine pyloric pressure. Am J Physiol 222:428–431

    PubMed  CAS  Google Scholar 

  • Ivy AC, Oldberg E (1928) A hormone mechanism for gallbladder contraction and evacuation. Am J Physiol 65:599–613

    Google Scholar 

  • Jensen RT, Coy DH (1991) Progress in the development of potent bombesin receptor antagonists. Trends Pharmacol Sci 12:13–19

    Article  PubMed  CAS  Google Scholar 

  • Jensen RT, Jones SW, Folkers K, Gardner JD (1984) A synthetic peptide that is a bombesin-receptor antagonist. Nature 309:61–63

    Article  PubMed  CAS  Google Scholar 

  • Jensen RT, Coy DH, Saeed ZA, Heinz-Erian P, Montey S, Gardner JD (1988) Interaction of bombesin and related peptides with receptors on pancreatic acinar cells. Ann NY Acad Sci 547:138–149

    Article  PubMed  CAS  Google Scholar 

  • Jessell TM, Iversen LL (1977) Opiates analgesics inhibit substance P release from rat trigeminal nucleus. Nature 268:549–551

    Article  PubMed  CAS  Google Scholar 

  • Jorpes JE, Mutt V (1968) Structure of porcine cholecystokinin-pancreozymin. I. Cleavage with thrombin and with trypsin. Eur J Biochem 6:156–162

    Article  PubMed  Google Scholar 

  • Kakidani H, Furutani Y, Takahashi H, Noda M, Morimoto Y, Hirose T, Asai M, Inayama S, Nakanishi S, Numa S (1982) Cloning and sequence analysis of cDNA for porcine β-noe endorphine/dynorphin precursor. Nature 298:245–249

    Article  PubMed  CAS  Google Scholar 

  • Kataoka K, Taniguchi A, Shimizu H, Sods D, Okumo S, Yajima H, Kitawaga K (1978) Biological activity of neurotensin and its C-terminal partial sequences. Brain Res Bull 3:555–557

    Article  PubMed  CAS  Google Scholar 

  • Kimura I, Kimura M, Nakayama N, Kimura M (1983) Relaxation and Ca spike suppression in circular and longitudinal muscles of hog bile duct ampulla by CCK-C-terminal peptide. Arch Int Pharmacodyn 265:320–334

    PubMed  CAS  Google Scholar 

  • Kimura I, Kondoh T, Kimura M (1989) Effects of tetrodotoxin on relaxation of pig duodenal circular muscle induced by C-terminal fragments of cholecystokinin. Br J Pharmacol 96:739–745

    PubMed  CAS  Google Scholar 

  • Kislauskis E, Bullock B, McNeil S, Dobner PR (1988) The rat gene encoding neurotensin and neuromedin. J Biol Chem 263:4963–4968

    PubMed  CAS  Google Scholar 

  • Kitabgi P, Freychet P (1978) Effects of neurotensin on isolated intestinal smooth muscles. Eur J Pharmacol 50:349–357

    Article  PubMed  CAS  Google Scholar 

  • Kitabgi P, Vincent JP (1981) Neurotensin is a potent inhibitor of guinea pig colon contractile activity. Eur J Pharmacol 74:311–318

    Article  PubMed  CAS  Google Scholar 

  • Kitabgi P, Carraway R, Leeman SE (1976) Isolation of a tridecapeptide from bovine intestine tissue and its partial characterization as neurotensin. J Biol Chem 251:7053–7058

    PubMed  CAS  Google Scholar 

  • Kostka P (1991) Gastrointestinal neuropeptides and second messenger systems. In: Daniel ED (ed) Neuropeptide function in the gastrointestinal tract. CRC, Boca Raton, pp 249–271

    Google Scholar 

  • Kotani H, Hoshimaru M, Nawa H, Nakanishi S (1986) Structure and gene organization of bovine neuromedin K precursor. Proc Natl Acad Sci USA 83:7074–7078

    Article  PubMed  CAS  Google Scholar 

  • Krane IM, Naylor SL, Helin-Davis D, Chin WW, Spindel ER (1988) Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. J Biol Chem 263:13317–13323

    PubMed  CAS  Google Scholar 

  • Laneuville O, Dorais J, Couture R (1988) Characterization of the effects produced by neurokinins and three agonists selective of neurokinin receptor subtypes in a spinal nocieptive reflex of the rat. Life Sci 42:1295–1305

    Article  PubMed  CAS  Google Scholar 

  • Laufer R, Wormser V, Friedman ZY, Gilon C, Chorev M, Selinger Z (1985) Neurokinin B is a prefered agonist for a neuronal substance P receptor and its action is antagonized by enkephalins. Proc Natl Acad Sci USA 82:7444–7448

    Article  PubMed  CAS  Google Scholar 

  • Laws PY, Hom DS, Loh HH (1983) Opiate regulation of adenosine 31:51-cyclic monophosphate level in neuroblastoma x glioma NG 108-15 hybrid cells. Relationship between receptor occupancy and effect. Mol Pharmacol 23:26–35

    Google Scholar 

  • Lee HK, Wang SC (1975) Mechanism of morphine-induced miosis in the dog. J Pharmacol Exp Ther 192:415–431

    PubMed  CAS  Google Scholar 

  • Lefkowitz RJ, Kobilka BK, Caron MG (1989) The new biology of drug receptors. Biochem Pharmacol 38:2941–2948

    Article  PubMed  CAS  Google Scholar 

  • Lehy T, Accary JP, Labeille D, Dubrasquet M (1983) Chronic administration of bombesin stimulates antral gastric cell proliferation in rat. Gastroenterology 84:914–919

    PubMed  CAS  Google Scholar 

  • Lemaire S, Magnan J, Regoli D (1978) Rat vas deferens: a specific bioassay for endogenous opioid peptides. Br J Pharmacol 64:327–329

    PubMed  CAS  Google Scholar 

  • Lhoste E, Aprahamian M, Pousse A, Hoeltzel A, Stock-Damgé C (1985) Trophic effect of bombesin on the rat pancreas: is it mediated by the release of gastrin or cholecystokinin? Peptides 6:89–97

    Article  PubMed  CAS  Google Scholar 

  • Li Ch, Chung D (1976) Isolation and structure of an untriakonta peptide with opiate activity from camel pituitary glands. Proc Natl Acad Sci USA 73:1145–1148

    Article  PubMed  CAS  Google Scholar 

  • Liston DR, Vanderhaeghen JJ, Rossier J (1983) Presence in brain of synenkephalin, a proenkephalin-immunoreactive protein which does not contain enkephalin. Nature 302:62–65

    Article  PubMed  CAS  Google Scholar 

  • Lord JAH, Waterfield AA, Hughes J, Kosterlitz HW (1977) Endogenous opioid peptide: multiple agonists and receptors. Nature 267:495–499

    Article  PubMed  CAS  Google Scholar 

  • Lotti VJ, Pendleton RG, Gould RJ, Hanson HM, Chang RSL, Clineschmidt BV (1987) In vivo pharmacology of L-364.718, a new potent non peptide peripheral cholecystokinin antagonist. J Pharmacol Exp Ther 241:103–109

    PubMed  CAS  Google Scholar 

  • Maggi CA, Giuliani S, Santiciolli P, Abelli L, Regoli D, Meli A (1987a) Further studies on the mechanism of the tachykinin-induced activation of micturition reflex in rats: evidence for the involvement of the capsaicin-sensitive bladder mechanoreceptors. Eur J Pharmacol 136:189–205

    Article  PubMed  CAS  Google Scholar 

  • Maggi CA, Giuliani S, Santicioli P, Regoli D, Meli A (1987b) Peripheral effects of neurokinins: functional evidence for the existence of multiple receptors. J Auton Pharmacol 7:11–32

    Article  PubMed  CAS  Google Scholar 

  • Maggi CA, Patacchini R, Giuliani S, Rovero P, Dion S, Regoli D, Giachetti A, Meli A (1990) Competitive antagonists discriminate between NK2 tachykinin receptor subtypes. Br J Pharmacol 100:583–592

    Google Scholar 

  • Maggi CA, Patacchini R, Astolfi M, Rovero P, Giuliani S, Giachetti A (1991) NK-2 receptor agonists and antagonists. Ann NY Acad Sci 632:184–191

    Article  PubMed  CAS  Google Scholar 

  • Marshall FH, Barnes S, Hughes J, Woodruff GN, Hunter JC (1991) Cholecystokinin modulates the release of dopamine from the anterior and posterior nucleus accumbens by two different mechanisms. J Neurochem 56:917–922

    Article  PubMed  CAS  Google Scholar 

  • Martin WR (1967) Opioid antagonists. Pharmacol Rev 19:463–521

    PubMed  CAS  Google Scholar 

  • Martin WR (1984) Pharmacology of opioids. Pharmacol Rev 35:283–323

    Google Scholar 

  • Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE (1976) The effects of morphine and neomorphine-like drugs in the non-dependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther 197:517–532

    PubMed  CAS  Google Scholar 

  • Mastrangelo D, Mathison R, Huggel HJ, Dion S, D’Orléans-Juste P, Rhaleb NE, Drapeau G, Rovero P, Regoli D (1987) The rat isolated portal vein: a preparation sensitive to neurokinins, particularly neurokinin B. Eur J Pharmacol 134:321–336

    Article  PubMed  CAS  Google Scholar 

  • Masu Y, Nakayama K, Tamaki H, Harada Y, Kuno M, Nakanishi S (1987) cDNA cloning of bovine substance K receptor through oocyte expression system. Nature 329:836–838

    Article  PubMed  CAS  Google Scholar 

  • McClane TK, Martin WR (1967) Antagonism of the spinal cord effects or morphine and cyclazocine by naloxone and thebaine. Int J Neuropharmacol 6:325–327

    Article  PubMed  CAS  Google Scholar 

  • McDonald TJ, Jörnvall H, Nilsson G, Vagne M, Ghatei M, Bloom SR, Mutt V (1979) Characterization of gastrin-releasing peptide from porcine non antral gastric tissue. Biochem Biophys Res Commun 90:227–233

    Article  PubMed  CAS  Google Scholar 

  • McDonald TJ (1991) Gastroenteropancreatic regulatory peptide structures: an overview. In: Daniel EE (ed) Neuropeptide function in the gastrointestinal tract. CRC, Boca Raton, pp 19–86

    Google Scholar 

  • McGilliard KL, Takemori AE (1978) Antagonism by naloxone of narcotic-induced respiratory depression and analgesia. J Pharmacol Exp Ther 207:494–503

    PubMed  CAS  Google Scholar 

  • McQueen DS (1983) Opioid peptide interactions with respiratory and circulatory systems. Br Med Bull 39:77–82

    PubMed  CAS  Google Scholar 

  • McRoberts JW (1986) Cholecystokinin and pain: a review. Anesth Prog 33:87–90

    PubMed  CAS  Google Scholar 

  • Merrifield RB (1963) Solid-phase peptide synthesis. I. The synthesis of a tetrapeptide. J Am Chem Soc 85:2149–2152

    Article  CAS  Google Scholar 

  • Miller LJ, Jardine I, Weissman E, Go VL, Speicher D (1984) Characterization of cholecystokinin from the human brain. J Neurochem 43:835–840

    Article  PubMed  CAS  Google Scholar 

  • Milligan G, Streaty RA, Gierschik P, Spiegel AM, Klee WA (1987) Development of opiate receptors and GTP-binding regulatory proteins in neonatal rat brain. J Biol Chem 262:8626–8630

    PubMed  CAS  Google Scholar 

  • Minamino N, Kangawa K, Matsuo H (1983) Neuromedin B: a novel bombesin-like peptide identified in porcine spinal cord. Biochem Biophys Res Commun 114: 541–548

    Article  PubMed  CAS  Google Scholar 

  • Minamino N, Kangawa K, Matsuo H (1984a) Neuromedin N: a novel neurotensinlike peptide identified in porcine spinal cord. Biochem Biophys Res Commun 122:542–549

    Article  PubMed  CAS  Google Scholar 

  • Minamino N, Kangawa K, Matsuo H (1984b) Neuromedin C: a bombesin-like peptide identified in porcine spinal cord. Biochem Biophys Res Commun 119: 14–20

    Article  PubMed  CAS  Google Scholar 

  • Mizrahi J, Dion S, D’Orléans-Juste P, Regoli D (1985) Activities and antagonism of bombesin on urinary smooth muscles. Eur J Pharmacol 111:339–345

    Article  PubMed  CAS  Google Scholar 

  • Morgan JP, Morgan KG (1982) Vascular smooth muscle: the first recorded Ca2+ transients Pflugers Arch 395:75–77

    Article  PubMed  CAS  Google Scholar 

  • Morgan KG, Szurszewski JH (1980) Mechanisms of phasic and tonic actions of pentagastrin on gastric smooth muscle. J Physiol (Lond) 301:229–242

    CAS  Google Scholar 

  • Morgan-Boyd R, Stewart JM, Vavrek RJ, Hassis A (1987) Effects of bradykinin and angiotensin II intracellular Ca2+ dynamics in endothelial cells. Am J Physiol 253:C588–C598

    PubMed  CAS  Google Scholar 

  • Morley JE (1980) The neuroendocrine controls of appetite: the role of endogenous opiates, cholecystokinin, TRH, gamma-amino-butiric acid and diazepam receptors. Life Sci 27:355–368

    Article  PubMed  CAS  Google Scholar 

  • Mosberg HI, Hurst R, Hruby VG, Gee K, Yamamura HI, Galligan JJ, Burks PF (1983) Bispenicillamine enkephalins possess highly-improved specificity towards δ opioid receptors. Proc Natl Acad Sci USA 80:5871–5874

    Article  PubMed  CAS  Google Scholar 

  • Mousli M, Bueb JL, Bronner C, Rouot B, Landry Y (1990) G-protein activation: a receptorindependent mode of action for cationic amphilic neuropeptides and venom peptides. TIPS 11:358–362

    PubMed  CAS  Google Scholar 

  • Muallem S, Pandol SJ, Beeker TG (1989) Hormone-evoked calcium release from intracellular stores is a quantal process. J Biol Chem 264:205–212

    PubMed  CAS  Google Scholar 

  • Mudge AW, Leeman SE, Fischbach GD (1979) Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration. Proc Natl Acad Sci USA 76:526–530

    Article  PubMed  CAS  Google Scholar 

  • Murphy RB, Smith GP, Gibbs J (1987) Pharmacological examination of CCK-8-induced contractile activity in the rat isolated pylorus. Peptides 8:127–134

    Article  PubMed  CAS  Google Scholar 

  • Mutt V (1983) New approaches to the identification and isolation of hormonal polypeptides. Trends Neurosci 6:357–360

    Article  CAS  Google Scholar 

  • Mutt V (1988) Secretin and cholecystokinin. In: Mutt V (ed) Gastrointestinal hormones, vol 2. Academic, New York, p 251

    Google Scholar 

  • Nakajima T, Tanimura T, Pisano JJ (1970) Isolation and structure of a new vasoactive peptide (Abstr) Fed Proc 29:282

    Google Scholar 

  • Nakanishi S (1986) Structure and regulation of the preprotachykinin gene. Trends Neurosci 9:41–44

    Article  CAS  Google Scholar 

  • Naline E, Devillier P, Drapeau G, Toty L, Bakdach H, Regoli D, Advenier C (1989) Characterization of neurokinins effects and receptor selectivity in human isolated bronchi. Am Rev Respir Dis 140:679–686

    PubMed  CAS  Google Scholar 

  • Nantel F, Rouissi N, Rhaleb NE, Dion S, Drapeau G, Regoli D (1990) The rabbit jugular vein is a contractile NK-1 receptor system. Eur J Pharmacol 179:457–462

    Article  PubMed  CAS  Google Scholar 

  • Nantel F, Rouissi N, Rhaleb NE, Jukic D, Regoli D (1991) Pharmacological evaluation of the angiotensin, kimin and neurokinin receptors on the rabbit vena cava. J Cardiovasc Pharmacol 18:398–405

    Article  PubMed  CAS  Google Scholar 

  • Nau R, Schafer G, Deacon CF, Cole T, Agaston DV, Conlon JM (1986) Proteolytic inactivation of substance P and neurokinin A in the longitudinal muscle layer of guinea pig small intestine. J Neurochem 47:856–864

    Article  PubMed  CAS  Google Scholar 

  • Nawa H, Hirose T, Takashima H, Inayama S, Nakanishi S (1983) Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor. Nature 306:32–36

    Article  PubMed  CAS  Google Scholar 

  • Negri L (1986) Satiety and scratching effects of bombesin-like peptides. Eur J Pharmacol 132:207–212

    Article  PubMed  CAS  Google Scholar 

  • Nemeroff CB (1980) Neurotensin: perchance an endogenous neuroleptic? Biol Psychiatry 15:283–302

    PubMed  CAS  Google Scholar 

  • Nemeroff CB, Osbahr AJ, Manberg PJ, Ervin GN, Prange AJ (1979) Alteration in nociceptive and body temperature after intracisternally-administered neurotensin, β-endorphine, other endogenous peptides and morphine. Proc Natl Acad Sci USA 76:5368–5371

    Article  PubMed  CAS  Google Scholar 

  • Nemeroff CB, Binette G, Manberg PJ, Osbahr AJ, Breese GR, Prange AJ (1980) Neurotensin induced hypothermia: evidence for an interaction with dopaminergic system and the hypothalamic-pituitary-thyroid axis. Brain Res 195:69–84

    Article  PubMed  CAS  Google Scholar 

  • North RA, Williams JT (1985) On the potassium conductance increased by opioids in rat locus coeruleus neurones. J Physiol (Lond) 364:265–280

    CAS  Google Scholar 

  • North RA, Williams JT, Surprenant A, Christie MJ (1987) μ and δ receptors belong to a family of receptors that are coupled to potassium channels. Proc Natl Acad Sci USA 84:5487–5491

    Article  PubMed  CAS  Google Scholar 

  • Ohkawa H, Watanabe M (1977) Effect of gastrointestinal hormones on the electrical and mechanical activities on cat small intestine. Jpn J Physiol 27:271–279

    Article  Google Scholar 

  • Oka T, Negishi K, Suda M, Matsumiya T, Inazu T, Ueki M, Vekimasaaki V (1980) Rabbit vas deferens: a specific bioassay for opioid K-receptor agonists. Eur J Pharmacol 73:235–236

    Article  Google Scholar 

  • Opmeer FA, Peter J, Burbach H, Wiegant VM, Van Ree JM (1982) β-endorphin proteolysis by guinea pig ileum myenteric plexus membranes: increased γ-endorphin turnover after chronic exposure to morphine. Life Sci 31:323–328

    Article  PubMed  CAS  Google Scholar 

  • Orloff MS, Reeve JR, Ben Avram C, Shively JE, Walsh JH (1984) Isolation and sequence analysis of human bombesin-like peptides. Peptides 5:865–870

    Article  PubMed  CAS  Google Scholar 

  • Pandol SJ, Schoeffield MS, Sachs G, Muallem S (1985) Role of free cytosolic calcium in secretagogue-stimulated anylase release from dispersed acini from guinea pig pancreas. J Biol Chem 260:10081–10086

    PubMed  CAS  Google Scholar 

  • Patacchini R, Astolfi M, Quartara L, Rovero P, Giachetti A, Maggi CA (1991) Further evidence for the existence of NK-2 tachykinin receptor subtypes. Br J Parmacol 104:91–96

    CAS  Google Scholar 

  • Paton WDM (1957) The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea pig ileum. Br J Pharmacol 12:119–127

    CAS  Google Scholar 

  • Pelton JT, Gulya K, Hruby VG, Duckies SP, Yamamura HI (1985) Comformationally restricted analogues of somatostatin with high μ opioid receptor specificity. Proc Natl Acad Sci USA 82:236–239

    Article  PubMed  CAS  Google Scholar 

  • Pendleton RG, Bendesky RJ, Schaffer L, Nolan TE, Gould RJ, Clineschmidt BV (1987) Roles of endogenous cholecystokinin in biliary, pancreatic and gastric function: studies with L-364-718 specific cholecystokinin receptor antagonist. J Pharmacol Exp Ther 241:110–116

    PubMed  CAS  Google Scholar 

  • Polak JM, Hamid, Springall DR, Cuttita F, Spindel E, Ghatei MA, Bloom SR (1988) Localization of bombesin-like peptides in tumors. Ann NY Acad Sci 547:322–335

    Article  PubMed  CAS  Google Scholar 

  • Portoghese PS, Takemori AE (1985) TENA, a selective κ opioid receptor antagonist. Life Sci 36:801–805

    Article  PubMed  CAS  Google Scholar 

  • Powell DW (1981) Muscle or mucosa: the site of action of antidiarrheal opiates? Gastroenterology 80:406–408

    PubMed  CAS  Google Scholar 

  • Pozo MJ, Salido GM, Madrid JA (1989) Cholecystokinin-induced gall bladder contraction is influenced by nicotinic acid and muscarinic receptors. Arch Int Physiol Biochim 97:403–408

    Article  PubMed  CAS  Google Scholar 

  • Prange A, Nemeroff CB (1982) The manyfold actions of neurotensin: a first synthesis. Am NY Acad Sci 400:368–375

    Article  CAS  Google Scholar 

  • Quirion R, Rioux F, Regoli D, St-Pierre S (1979) Neurotensin-induced coronary vessel constriction in perfused rat hearts. Eur J Pharmacol 55:221–223

    Article  PubMed  CAS  Google Scholar 

  • Quirion R, Regoli D, Rioux F, St-Pierre S (1980a) Structure activity studies with neurotensin: analysis of positions 9, 10 and 11. Br J Pharmacol 69:689–692

    PubMed  CAS  Google Scholar 

  • Quirion R, Rioux F, Regoli D, St-Pierre S (1980b) Compound 48/80 inhibits neurotensin-induced hypotension in rats. Life Sci 27:1889–1895

    Article  PubMed  CAS  Google Scholar 

  • Rakovska A, Milenov K, Yanev S (1986) Mode of action of cholecystokinin octapeptide on smooth muscles of stomach, ileum and gall bladder. Methods and Findings in Experimental and Clinical Pharmacology 8:697–703

    PubMed  CAS  Google Scholar 

  • Rattan S, Goyal RK (1983) Pharmacological differences between neural (inhibitory) and muscle (excitatory) CCK receptors in the cat lower esophageal sphincter (Abstr). Gastroenterology 84:1281

    Google Scholar 

  • Regoli D (1982) Vascular receptors for polypeptides. Trends Pharmacol Sci 3: 286–288

    Article  CAS  Google Scholar 

  • Regoli D (1987) Peptides, receptors, antagonists. TIPS 8: Centrefold January issue

    Google Scholar 

  • Regoli D, Nantel F (1990) Receptor-independent action of bradykinin. Direct activation of G proteins. Trends Pharmacol Sci 11:400–401

    Article  PubMed  CAS  Google Scholar 

  • Regoli Nantel F (1991) Pharmacology of neurokinin receptors. Biopolymers

    Google Scholar 

  • Regoli D, Escher E, Drapeau G, D’Orléans-Juste P, Mizrahi J (1984) Receptors for substance P. III. Classification by competitive antagonists. Eur J Pharmacol 97:179–189

    Article  PubMed  CAS  Google Scholar 

  • Regoli D, Drapeau G, Dion S, D’Orléans-Juste P (1987) Pharmacological receptors for substance P and neurokinins. Life Sci 40:109–117

    Article  PubMed  CAS  Google Scholar 

  • Regoli D, Drapeau G, Dion S, Couture R (1988) New selective agonists for neurokinin receptors: pharmacological tools for receptor characterization. Trends Pharmacol Sci 9:290–295

    Article  PubMed  CAS  Google Scholar 

  • Regoli D, Dion S, Rhaleb NE, Drapeau G, Rouissi N, D’Orléans-Juste P (1989a) Receptors for neurokinins, tachykinins and bombesin: a pharmacological study Ann NY Acad Sci 547:158–173

    Article  Google Scholar 

  • Regoli D, Drapeau G, Dion S, D’Orléans-Juste P (1989b) Receptors for substance P and related neurokinins. A mini-review. Pharmacology 38:1–15

    Article  PubMed  CAS  Google Scholar 

  • Regoli D, Rhaleb NE, Dion S, Tousignant C, Rouissi NE, Jukic D, Drapeau G (1990a) Neurokinin A. A pharmacological study. Pharmacol Res 22:1–14

    Article  PubMed  CAS  Google Scholar 

  • Regoli D, Rhaleb NE, Dion S, Drapeau G (1990b) New selective bradykinin receptor antagonists and bradykinin B2 receptor characterization. Trends Pharmacol Sci 11:156–161

    Article  PubMed  CAS  Google Scholar 

  • Rehfeld JF (1986) Accumulation of nonamidated preprogastrin and preprocho-lecystokinin products in porcine pituitary corticotrophs. J Biol Chem 261: 5841–5847

    PubMed  CAS  Google Scholar 

  • Renfeld JF, Hansen HF, Marley PD, Stenjard-Pedersen K (1985) Molecular forms of cholecystokinin in the brain and the relationship to neuronal gastrin Ann N Y Acad Sci 448:11–23

    Article  Google Scholar 

  • Resin H, Stern DH, Sturdevant R, Isenberg JL (1973) Effect of the C-terminal of cholecystokinin on lower esophageal sphincter pressure in man. Gastroenterology 64:946–949

    PubMed  CAS  Google Scholar 

  • Rioux F, Park WK, Regoli D (1973) Application of drug-receptor theories to angiotensin. Can J Physiol Pharmacol 51:665–672

    Article  PubMed  CAS  Google Scholar 

  • Rioux F, Quirion R, Regoli D, Leblanc MA, St-Pierre S (1980) Possible interactions between neurotensin and prostaglandins in the isolated rat portal vein Life Sci 27:259–267

    Article  PubMed  CAS  Google Scholar 

  • Rioux F, Lemieux M, Kerouac R, Bernoussi A, Roy G (1989) Local application of neurotensin to abdominal organs triggers cardiovascular reflexes in guinea pigs: possible mechanisms. Peptides 10:647–655

    Article  PubMed  CAS  Google Scholar 

  • Rodgers DF, Aursudkij B, Barnes PJ (1989) Effects of tachykinins on mucus secretion in human bronchi in vitro. Eur J Pharmacol 174: 283–286

    Article  Google Scholar 

  • Rogers J, Hughes RG, Mathews EK (1988) Cyclic GMP inhibits protein kinase C-mediated secretion in rat pancreatic acini. J Biol Chem 263:3713–3719

    PubMed  CAS  Google Scholar 

  • Rökaeus A (1991) Regulation of gastrointestinal neuropeptide gene expression and processing. In: Daniel EE (ed) Neuropeptide function in the gastrointestinal tract. CRC, Boca Raton, pp 87–129

    Google Scholar 

  • Rollandy I, Guillemain I, Imhoff V, Drapeau G, Regoli D, Rossignol B (1991) Involvement of NK-1 receptors and importance of the N-terminal sequence of substance P in the stimulation of protein secretion in rat parotid glands. Eur J Pharmacol 209:95–100

    Article  PubMed  CAS  Google Scholar 

  • Roques BP, Beaumont A (1990) Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives? Trends Pharmacol Sci 11:245–249

    Article  PubMed  CAS  Google Scholar 

  • Roques BP, Fournie-Zaluski MC (1986) Enkephalin-degrading enzyme inhibitors: a physiological way to new analgesics and psychoactive agents. NIDA Res Monogr Ser 70:128–154

    CAS  Google Scholar 

  • Roques BP, Fournié-Zaluski MC, Soroca E, Lecomte JH, Malfroy B, Llorens C, Schwartz JC (1980) The enkephalinase inhibitor thiorphan shows anti nociceptive activity in mice. Nature 288:286–288

    Article  PubMed  CAS  Google Scholar 

  • Rosell S (1977) Actions of neurotensin and [Gln4]-neurotensin on isolated tissues. Acta Pharmacol Toxicol (Copenh) 41:141–147

    Google Scholar 

  • Rossie SS, Miller RJ (1982) Regulation of mast cell histamine release by neuro-tensine. Life Sci 31:509–516

    Article  PubMed  CAS  Google Scholar 

  • Rouissi N, Nantel F, Drapeau G, Rhaleb N-E, Dion S, Regoli D (1990a) Inhibitors of peptidases: how they influence the biological activities of substance P, neurokinins, bradykinin and angiotensin in guinea pig, hamster and rat urinary bladders. Pharmacology 40:196–204

    Article  PubMed  CAS  Google Scholar 

  • Rouissi N, Nantel F, Drapeau G, Rhaleb NE, Dion S, Regoli D (1990b) Inhibitors of peptidases: how they influence the biological activities of substance P, neurokinins, kinins and angiotensins in isolated vessels. Pharmacology 40:185–195

    Article  PubMed  CAS  Google Scholar 

  • Rouissi N, Rhaleb NE, Nantel F, Dion S, Drapeau G, Regoli D (1991a) Characterization of bombesin receptors in peripheral contractile organs. Brit J Pharmacol 103:1141–1147

    CAS  Google Scholar 

  • Rouissi N, Gitter BD, Waters DC, Howbert JJ, Nixon JA, Regoli D (1991b) Selectivity and specificity of new, non peptide, quinuclidine antagonists of substance P. Biochem Biophys Res Commun 176:894–901

    Article  PubMed  CAS  Google Scholar 

  • Rozengurt E (1988) Bombesin-induction of cell prolipheration in 3T3 cells: specific receptors and early signaling events. Ann NY Acad Sci 547:277–292

    Article  PubMed  CAS  Google Scholar 

  • Salem H, Aviasto DM (eds) (1970) Antitussive agents, vols 1–3. Pergamon, Oxford International encyclopedia of pharmacology and therapeutics, sect 27

    Google Scholar 

  • Sausville EA, Moyer JD, Heikkila R, Neckers LM, Trepel JB (1988) A correlation of bombesin responsiveness with myc-family gene expression in small cell lung carcinoma cell lines. Ann NY Acad Sci 547:310–321

    Article  PubMed  CAS  Google Scholar 

  • Sasai Y, Nakanishi S (1989) Molecular characterisation of rat substance K receptors and its mRNAs. Biochem Biophys Res Commun 165:695–702

    Article  PubMed  CAS  Google Scholar 

  • Schang JC, Hemond M, Hebert M, Pilote M (1986) How does morphine work on colonic motility? An electro myographic study in the human left and sigmoid colon. Life Sci 38:671–676

    Article  PubMed  CAS  Google Scholar 

  • Scheurer UL, Varga L, Drack E, Burk HR, Halter F (1983) Mechanisms of action of CCK-octapeptide on rat antrum pylorus and duodenum. Am J Physiol 244: G266–G272

    PubMed  CAS  Google Scholar 

  • Schild HO (1947) pAx, a new scale for the measurement of drug antagonism. Br J Pharmacol 2:189–206

    CAS  Google Scholar 

  • Schutzberg M, Hökfelt T, Lundberg JM (1982) Co-existence of classical transmitters and peptides in the central and peripheral nervous system. Br Med Bull 38: 309–318

    Google Scholar 

  • Selbekk BH, Flaten O, Hanssen LE (1980) The in vitro effect of neurotensin on human jejunum mast cells. Scand J Gastroenterol 15:457–460

    Article  PubMed  CAS  Google Scholar 

  • Severi C, Grider JR, Makhlouf GH (1988) Identification of separate bombesin and substance P precursors on isolated muscle cells from canine gallbladder. J Pharmacol Exp Ther 245:195–198

    PubMed  CAS  Google Scholar 

  • Shigemoto R, Yokota Y, Tsuchida K, Nakanishi S (1990) Cloning and expression of rat neuromedin K receptor cDNA. J Biol Chem 265:623–628

    PubMed  CAS  Google Scholar 

  • Smith GM, Lowenstein E, Hubbard JH, Beecher HK (1968) Experimental pain produced by the submaximum effort tourniquet technique: further evidence of validity. J Pharmacol Exp Ther 163:468–474

    PubMed  CAS  Google Scholar 

  • Snider RM, Constantine JW, Lowe JA, III Longo KP, Lebel WS, Woody HA, Drozda SE, Desai MC, Vinick FJ, Spencer RW, Hess HJ (1991) A potent non peptide antagonist of the substance P (NK-1) receptor. Science 251:435–437

    Article  PubMed  CAS  Google Scholar 

  • Spindel ET, Zilberberg MD, Habener JF, Chin WW (1986) Two prohormones for gastrin releasing peptide are encoded by two mRNAs differing by 19 nucleotides. Proc Natl Acad Sci USA 83:19–23

    Article  PubMed  CAS  Google Scholar 

  • Spindel ET, Giladi E, Brehm P, Goodman RH, Segerson TP (1990) Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor. Mol Endocrinol 4:1956–1963

    Article  PubMed  CAS  Google Scholar 

  • St-Pierre S, Kerouac R, Quirion R, Jolicoeur FB, Rioux F (1984) Neurotensin. Pept Protein Rev 2:83–171

    CAS  Google Scholar 

  • Studer RO, Trzeciak A, Lergier W (1973) Isolierung und Aminosäuresequenz von Substanz P aus Pferdedarm. Helv Chim Acta 56:860–866

    Article  CAS  Google Scholar 

  • Sutter MC (1990) The mesenteric-portal vein in research. Pharmacol Rev 42:287–325

    PubMed  CAS  Google Scholar 

  • Taché Y (1988) Summary and concluding remarks. Bombesin-like peptides in health and disease. Ann NY Acad Sci 547:429–437

    Article  Google Scholar 

  • Takahashi Y, Kato K, Hayashizaki Y, Wakabayashi T, Ohtsuka E, Matsuki S, Ikehara M, Matsubara K (1985) Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxynosine. Proc Natl Acad Sci USA 82:1931–1935

    Article  PubMed  CAS  Google Scholar 

  • Takemori AE, Portoghese PS (1985) Receptors for opioid peptides in the guinea pig ileum. J Pharmacol Exp Ther 235:389–392

    PubMed  CAS  Google Scholar 

  • Takemoto K, Lundberg JM, Jörnvall H, Mutt V (1985) Neuropeptide K: isolation, structure and biological activities of a novel brain tachykinin. Biochem Biophys Res Commun 128:947–953

    Article  Google Scholar 

  • Tanaka K, Masu M, Nakanishi S (1990) Structure and functional expression of the cloned rat neurotensin receptor. Neuron 4:847–854

    Article  PubMed  CAS  Google Scholar 

  • Tousignant C, Dion S, Drapeau G, Regoli D (1987) Characterization of pre and postfunctional receptors for kinins and neurokinins in the rat vas deferens. Neuropeptides 9:333–343

    Article  PubMed  CAS  Google Scholar 

  • Ueda N, Muramatsu I, Taniguchi T, Nakanishi S, Fujiwaea M (1986) Effects of neurokinin A, substance P and electrical stimulation on the rabbit iris sphincter muscle. J Pharmacol Exp Ther 239:494–499

    PubMed  CAS  Google Scholar 

  • Valenzuela JE (1976) Effect of intestinal hormones and peptides on intragastric pressure in dogs. Gastroenterology 71:766–769

    PubMed  CAS  Google Scholar 

  • Varner AA, Modlin IM, Walsh JH (1981) High potency of bombesin for stimulation of human gastrin release and gastric acid secretion. Regul Pept 1:289–296

    Article  PubMed  CAS  Google Scholar 

  • Vizi ES, Bertaccini G, Impicciatore M, Knoll J (1972) Acetylcholine-releasing effect of gastrin and related polypeptides. Eur J Pharmacol 17:175–178

    Article  PubMed  CAS  Google Scholar 

  • Von Euler US (1936) Preparation of substance P. Scand Arch Physiol 73:142–144

    Google Scholar 

  • Von Euler US, Gaddum JH (1931) An unidentified depressor substance in certain tissue extracts. J Physiol (Lond) 72:74–87

    Google Scholar 

  • Wado E, Way J, Shapira H, Kusano K, Lebacq-Verheyden AM, Coy D, Jensen R, Battery J (1991) cDNA cloning, characterization and brain region specific expression of a neuromedin-B preferring bombesin receptor. Neuron 6:421–430

    Article  Google Scholar 

  • Walsh JH (1987) Gastrointestinal hormones - cholecystokinin. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, p 195

    Google Scholar 

  • Wamsley JK (1983) Opioid receptors: autoradiography. Pharmacol Rev 35:69–83

    PubMed  CAS  Google Scholar 

  • Watkins LR, Kinscheck IB, Mayer DJ (1985) Potentiation of morphine analgesia by the cholecystokinin antagonist proglumide. Brain Res 327:169–180

    Article  PubMed  CAS  Google Scholar 

  • Watson SJ, Akil H, Ghazarossian VE, Goldstein A (1981) Dynorphin immunocytochemicals localization in brain and peripheral nervous sytem: preliminary studies. Proc Natl Acad Sci USA 78:1260–1263

    Article  PubMed  CAS  Google Scholar 

  • Watson SJ (1984) The action of substance P on contraction, inositol phospholipids and adenylate cyclase in rat small intestine. Biochem Pharmacol 33:3733–3737

    Article  PubMed  CAS  Google Scholar 

  • Widerlöv E, Lindstrom LH, Besev G, Manberg PJ, Nemeroff CB, Breese GR, Kizer JS, Prange AJ (1982) Subnormal CSF levels of neurotensin in a subgroup of schizophrenic patients: normalization after neuroleptic treatment. Am J Psychiatry 139:1122–1126

    PubMed  Google Scholar 

  • Williams JA, McChesney DJ, Calayag MC, Lingappa VR, Logsdon CD (1988) Expression of receptors for cholecystokinin and other Ca2+ mobilizing hormones in xenopus oocytes. Proc Natl Acad Sci USA 85:4939–4943

    Article  PubMed  CAS  Google Scholar 

  • Wolfe M, McGuigan JE (1984) Immunochemical characterization of gastrin and cholecystokininlike peptides released in dogs in response to a peptone meal. Gastroenterology 87:323–334

    PubMed  CAS  Google Scholar 

  • Woodruff GN, Hughes J (1991) Cholecystokinin antagonists. Annu Rev Pharmacol Toxicol 31:469–501

    Article  PubMed  CAS  Google Scholar 

  • Wuster M, Schulz R, Herz A (1980) The direction of opioids agonists towards μ, δ and κ receptors in the vas deferens of the mouse and the rat. Life Sci 27:163–170

    Article  PubMed  CAS  Google Scholar 

  • Yaksh TL, Jessel TM, Gamse R, Mudge AW, Leeman E (1980) Intrathecal morphine inhibits substance P release from mammalian spinal cord. Nature 286:155–157

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto Y, Holts K, Matanota T (1984) Effect of methionine-enkephalin on the spontaneous electrical and mechanical activity of the smooth muscle of the rat portal vein. Life Sci 34:993–999

    Article  PubMed  CAS  Google Scholar 

  • Yamamura T, Takahashi T, Kusonoki M, Kantoh M, Ishikawa Y, Utsunomiya J (1986) Cholecystokinin octapeptide-evoked [3H] acetylcholine release from guinea pig gall bladder. Neurosci Lett 65:167–170

    Article  PubMed  CAS  Google Scholar 

  • Yau WM, Makhlouf GM, Edwards LE, Ferrar JT (1973) Mode of action of cholecystokinin and related peptides on gall bladder muscle. Gastroenterology 65:451–456

    PubMed  CAS  Google Scholar 

  • Yau WM, Makhlouf GM, Edwards LE, Farrar JT (1974) The action of cholecystokinin and related peptides on guinea pig small intestine. Can J Physiol Pharmacol 52:298–303

    Article  CAS  Google Scholar 

  • Yau WM, Lingle PF, Youther ML (1983) Interaction of enkephalin and caerulein on guinea pig small intestine. Am J Physiol 244:G65–G70

    PubMed  CAS  Google Scholar 

  • Yokota Y, Sasai Y, Tanaka K, Fujiwara T, Tsuchida K, Shigemato R, Kakiguka A, Ohkubo H, Nakanishi S (1989) Molecular characterization of a functional cDNA for rat ésubstance P receptor. J Biol Chem 264:17649–17652

    PubMed  CAS  Google Scholar 

  • Yu DH, Huang SC, Wank SA, Mantey S, Gardner JD, Jensen RT (1990) Pancreatic receptors for cholecystokinin: evidence for three receptor classes. Am J Physiol 258:G86–G95

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Regoli, D., Rouissi, N., D’Orléans-Juste, P. (1994). Neuropeptides (Neurokinins, Bombesin, Neurotensin, Cholecystokinins, Opioids) and Smooth Muscle. In: Szekeres, L., Papp, J.G. (eds) Pharmacology of Smooth Muscle. Handbook of Experimental Pharmacology, vol 111. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78920-5_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78920-5_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78922-9

  • Online ISBN: 978-3-642-78920-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics