Ionic Channels in Smooth Muscle

  • T. Tomita
  • S. Iino
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 111)

Abstract

Our fundamental knowledge of membrane currents and ionic channels in smooth muscle has advanced considerably following the introduction of the patch-clamp method about 10 years ago, and it is a field that is still rapidly expanding. Since the patch-clamp method uses single cells or membrane patches, however, there are limits to the precision of the correlation that can be obtained between the ionic currents analysed and their functional role, because smooth muscle functionally is a multicellular system. A combination of patch-clamp experiments and intracellular recording of tissues may be the best way to further our understanding of membrane currents. More information is also required about functional cell-to-cell coupling.

Keywords

Caffeine Cyanide Choline Butyrate Saponin 

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© Springer-Verlag Berlin Heidelberg 1994

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  • T. Tomita
  • S. Iino

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